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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for TAB3 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID257397
Official gene symbolTAB3
Full nameTGF-beta activated kinase 1/MAP3K7 binding protein 3
Aliases,MAP3K7IP3,MGC45404,NAP1,
Gene summaryThe product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq]
LocationChromosome: X   Locus: Xp21.2
Gene position30907511 - 30845559  Map Viewer
Gene orientationminus
Gene size61953 bp
Gene sequence
OMIM ID300480