Entrez gene ID | | 257397 |
Official gene symbol | | TAB3 |
Full name | | TGF-beta activated kinase 1/MAP3K7 binding protein 3 |
Aliases | | ,MAP3K7IP3,MGC45404,NAP1, |
Gene summary | | The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq] |
Location | | Chromosome: X Locus: Xp21.2 |
Gene position | | 30907511 - 30845559 Map Viewer |
Gene orientation | | minus |
Gene size | | 61953 bp |
Gene sequence |
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OMIM ID | | 300480 |