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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for FBXW2 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID26190
Official gene symbolFBXW2
Full nameF-box and WD repeat domain containing 2
Aliases,FBW2,Fwd2,MGC117371,Md6,
Gene summaryF-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats. [provided by RefSeq]
LocationChromosome: 9   Locus: 9q34
Gene position123555740 - 123519254  Map Viewer
Gene orientationminus
Gene size36487 bp
Gene sequence
OMIM ID609071