Entrez gene ID | | 26190 |
Official gene symbol | | FBXW2 |
Full name | | F-box and WD repeat domain containing 2 |
Aliases | | ,FBW2,Fwd2,MGC117371,Md6, |
Gene summary | | F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats. [provided by RefSeq] |
Location | | Chromosome: 9 Locus: 9q34 |
Gene position | | 123555740 - 123519254 Map Viewer |
Gene orientation | | minus |
Gene size | | 36487 bp |
Gene sequence |
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OMIM ID | | 609071 |
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