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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for FBXW8 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID26259
Official gene symbolFBXW8
Full nameF-box and WD repeat domain containing 8
Aliases,FBW6,FBW8,FBX29,FBXO29,FBXW6,MGC33534,
Gene summaryThis gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq]
LocationChromosome: 12   Locus: 12q24.22|tdb9938
Gene position117348761 - 117468953  Map Viewer
Gene orientationplus
Gene size120193 bp
Gene sequence
OMIM ID609073