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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for FBXO22 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID26263
Official gene symbolFBXO22
Full nameF-box protein 22
Aliases,FBX22,FISTC1,FLJ13986,MGC31799,
Gene summaryThis gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and, as a transcriptional target of the tumor protein p53, is thought to be involved in degradation of specific proteins in response to p53 induction. Alternative splicing results in multiple transcript variants. [provided by RefSeq]
LocationChromosome: 15   Locus: 15q24.2
Gene position76196200 - 76226944  Map Viewer
Gene orientationplus
Gene size30745 bp
Gene sequence
OMIM ID609096