Entrez gene ID | | 26269 |
Official gene symbol | | FBXO8 |
Full name | | F-box protein 8 |
Aliases | | ,DC10,FBS,FBX8, |
Gene summary | | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It contains a C-terminal amino acid sequence that bears a significant similarity with a portion of yeast Sec7p, a critical regulator of vesicular protein transport. This human protein may interact with ADP-ribosylation factor(s)(ARFs) and exhibit ARF-GEF (guanine nucleotide exchange factor) activity. [provided by RefSeq] |
Location | | Chromosome: 4 Locus: 4q34.1 |
Gene position | | 175205402 - 175157809 Map Viewer |
Gene orientation | | minus |
Gene size | | 47594 bp |
Gene sequence |
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OMIM ID | | 605649 |
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