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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for FBXO8 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID26269
Official gene symbolFBXO8
Full nameF-box protein 8
Aliases,DC10,FBS,FBX8,
Gene summaryThis gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It contains a C-terminal amino acid sequence that bears a significant similarity with a portion of yeast Sec7p, a critical regulator of vesicular protein transport. This human protein may interact with ADP-ribosylation factor(s)(ARFs) and exhibit ARF-GEF (guanine nucleotide exchange factor) activity. [provided by RefSeq]
LocationChromosome: 4   Locus: 4q34.1
Gene position175205402 - 175157809  Map Viewer
Gene orientationminus
Gene size47594 bp
Gene sequence
OMIM ID605649