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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for NARF (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID26502
Official gene symbolNARF
Full namenuclear prelamin A recognition factor
Aliases,DKFZp434G0420,FLJ10067,IOP2,
Gene summarySeveral proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing. [provided by RefSeq]
LocationChromosome: 17   Locus: 17q25.3
Gene position80416060 - 80446143  Map Viewer
Gene orientationplus
Gene size30084 bp
Gene sequence
OMIM ID605349