Entrez gene ID | | 26524 |
Official gene symbol | | LATS2 |
Full name | | LATS, large tumor suppressor, homolog 2 (Drosophila) |
Aliases | | ,FLJ13161,KPM, |
Gene summary | | This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq] |
Location | | Chromosome: 13 Locus: 13q11-q12 |
Gene position | | 21635722 - 21547175 Map Viewer |
Gene orientation | | minus |
Gene size | | 88548 bp |
Gene sequence |
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OMIM ID | | 604861 |
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