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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for GREM1 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 26585 Official gene symbol GREM1 Full name gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis) Aliases ,CKTSF1B1,DAND2,DRM,GREMLIN,IHG-2,MGC126660,PIG2, Gene summary This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] Location Chromosome: 15   Locus: 15q13-q15 Gene position 33010205 - 33026870  Map Viewer Gene orientation plus Gene size 16666 bp Gene sequence >GREM1:3800762..3817427:Length=16666 ACTCGGTGCGCCTTCCGCGGACCGGGCGACCCAGTGCACGGCCGCCGCGTCACTCTCGGT CCCGCTGACCCCGCGCCGAGCCCCGGCGGCTCTGGCCGCGGCCGCACTCAGCGCCACGCG TCGAAAGCGCAGGCCCCGAGGACCCGCCGCACTGACAGGTGAGCGCGGACGCACCCGGCA GGGATGTGAGTGGGCGGAGGGAAGAGGGCCGCAAACCAACCCAGGACCCGCTCAGTTCCA CGCGCGGCAGCCCTCCGTGCGCGCAGGCTCGGGTGCGTTGTTCGCGGGGGTGAATTGTGA AGAACCATCGCGGGGTCCTTCCTGCTGAGGCCGCGGACACCGTGACCTCGCTGCTCTGGG TCTGCAGGGAAACGTAGGAAAAAAAGTTGTCAGGAGCGGGCAGGATGACCCCCACATCCC GTTTCCACCTCCCGGAGGCCCCCGAACACGCTCCTGGTGCTGGTGGCAGCAGCGCCTGGC AGACGCGCCCGCTTAGCGAGGGCGCGAAGTCCAGGCCGCCAGAGCGCAGGAGCATCCGGA CCTGCTAGTCGGCCGCTGACTGCGCGGCGAGTTGCCTTGAGAGGGTCCCATGTGCTTGGG GCGCCGCGCTGGGTCTGGGGGCGTCTTGGGGCGCCCATTGGAGTCCGCGGGTTGGAGCAT CCGGAGAATCCATGATGTGTGCATTTGCCGATCCCCGAGGTGAGATGGAGACTGGCAAGG GCAGAGCCGCTGTGTTCAGCCACAGCGGAAAACCGAACGGTGGGTAATCCGACAGCTGCG GTGCGGGGCGCGGCCCTGGCCGCGGGGTCCAGCGAACCCGCAGTGCTCACAAGGCAGACA CCACACGCGCTCGCGGACCGGCCACGCACTCGCGGGCGCTCGCTTCTCTACTCCAGCCTC TTCCCCGCCCCGCGCACGCCCGGGCTGAATGGTAGACGTTCTGGCGCCGGGCAGCGGCCA CCGGCTGGTTCCCACTTCCGCGCGCACCCCTTAAACTGTGTTCTAGAGGCCCCAGCCTCG CCTTGCAGCGCCTCACTAGCTCCTGAGGACTAGGGACTGGCGGCTGAGGCGGGTTGGCGG CTGCAACGAGCTGGGCGTCTTTCGTTCTCTCTCGCTGCCTGGCTGGCTCCGCTGGCCCCT CCACAGCTTGCGGAGCAAGGCCATAGCAGGGGAGTGGGAGGTATATTGGGGCTGTCACCT CCTTGCTGGCCGGAGTTATTTGTAGACTACAGACTCCGGAAGAACAGACGCGCCACCGCT CTCGCTTGGCATTGCCTTCGGATCGCAGCTCCTCCTTGGGGGTGCCCCAGCTTGGCGTTT ATTTGCCTGCGCCAGGCTCTGGCGACGGTCACCGGGCCAGGCGGGGAGGGACGGACGGCA GGTGACCAGCCTCTGCTGTGAAGAAATTCCTGCGCGCCCGGAGCTGTCCCTAATGCATTC CCGGGTCGAATCCGTCTACTGCCTTCCCCTCCTCGACCGACTCCGAATCTCGGCTCTTAT AGACAGAAATACAGCCTCAGCGTTAGGGGTTAAAATCCCCCTCTTAAACGGTCCGAGGGC AGAGAGGTGACCACCGATAGGTAATTGGATCTCCTGCTGGAAAGAGCAAATCTGAGCGGT GTGCGCGTCTGTTTATGTTCCCCTTCGAGATGGTGCCAGGACACGAACTGATTAAAACAA TCTATTGTGTTAAGTGGGTCACTAGGGTTTTAAGCTGTCCCAGGGACCCCAGAGTAGTGG CTTCCTTCTGGCTGTACACACAAGTTAAATAAATAGCGTAGAAGAGGTTAAGATAACCCC ATTCTAGGGTGAGGAGTCCTCTTTCATCCCTAGGGCTTCCCCCTCCCCTTTTCTCTTTTT TTGGAAGGAGGGGGAGCATGAGAGTCTTGAGGGGGGGATGTACTTTTCAAAGCAAGGAGG GAAAGATCTTAAGAAAACTATATATTCTCACTGCCCCCCAAGCCAAGTCTATAACAGTAG GTGATTTGATTACTATCTCTGGATAAATGGCACTGTCAAATTGTTAATATTAACTATTTC AGGGATTTTTAGCAGGGTAGTGGCAGTATGTGTGCGTGTGTGTGTGTGTGTCTGTGTGTG TGTGTTTAACCTCCAGGTCATTGTAGGAATTAGAGTCTTTTGTAAACTTTGTAATTTCAC AGGTTTCCTATTTTCTTAAAAGTTCATTTTTAGTGAAATGTTTTGGTAACCCACGCTCTG TAGGAAATCCAGGTTGGCTAATGCGGTCTTTATGTGAGTAGTTACACAGGGAAGGATAAA AACCTTTTATGTCCTACATCTCTGAATGAGGGCTGCCTACCCTGTCTTTGAAACTAAGCC GAAGATGCCTTCAGTCTGAATGGTCAAGTATTAAAAGTGATAAAATGCAAAGAAATTTCA TGCCGCAGACACCTCCCCCAAGAACTGCTTGTTGACAGCAAAGCTGTGGAACATGTTCCA CAACAGAGAGTAAAGGACAGCCAGGAAATATAAACCTTTTATGTAAAGGAAAGGCAGGTG GGGGACAGTGGTTAGGGGAGGTGACTGCAGCCTCTAACCAAAAGGCAACCATCAGGCAAG TGCTACCAGCCCGTGTCTTCGATCTGCAAGGAATTTTCTTTAGTTTTAACATATGCTCTT AGAAATTCAAAGTACAACAGGAATTCCTGGGACAAGAGAAATCTTTTTATTCACATGTGA ACATGAAGATACAAAATAGATAATTATTTTATTTATAGCACTCTTCAAATTGTATTGCAT TAGAAAACATATCCATTGACCCACTGTTAAGGACAGCACTGGGTGTCAATAGGACAGTGG TTAAGGACCTGTGTTTGGGGCTAGATAGAATTGGGTTTAAACTGCTGGCTGGGCTAGGCA CAGTGGCTCACACCGGTAATCCCAGCACTTTGGGAGGCCAAGGAGGACGGATCACCTGAG GTCGGGAGTTCGACACCAGCCTGACCAACATGGAAAAATCCCGTCTCTACTAAAAACACA AAATTAGCCAGGCATGGTGGTGCATGCCTGCAATCCCAGCTACTTGGGAGGCTGAGGCAG GAGAATTGCTTGAAACCGGGAGGCGGAGGTTGTGGTGAGCCCAGATAGCGCCATTGCATT CCAGCCTGGGCAACACGAGTGAAAACTCCGTCAAAAAAACAAAACAAAACAAACAAACAA AAAAATGCTGGCTTTCCCACTTATGAGCTGTGTGACCTTGGACAAATTTCCAACTTTTCT GAGTGTAGATTCCCTGATTGGTAAAAGGAAGATGATATTATCTACCTCATATTTTGTTAT GAAAAATAAATGATAAAATTGGGTCAGAAATCAGCATAATGCCTGGCACAGTAAGGGCTT CAAAATAAAAGGTAGCTCTTATTATTAGTAATGGTGTTAGGAAAAGTAGCAATGTTATAC AGAACCAGGATATATCACAGGGCAGTTCTGAAATTAAATCCTGAATCCTGGCCGGGTGAG GTGGCTCACGCTTGTAATCCTAAGCACTTTCGGAGACTGAGGCAGGCGGATCACGAGGTC AGGAGTTTGAGACCAGCCTGGCCAAGACACTGAAATCCCGTCTCTACTAAAAATACAAAA ATTAGCTGGGTGTGGTGGCAGGCGCCTATAATCTCAGCTACTTGGGAGGCTGAGGCAGGA GAATCACTTGAGCCCAGGAGGCGGAGGTTGCAGTGAGCTGATATCGTGCCAGTGCACTCC AGCCTGGGTGACATCTCTTAAAAAAAAAAATCCTGAATACCACACTACGCAGTGACTAAC ACATCTTTCACTACAGAACAGAACCTGTAACTTGGCCGTCTCTCAGCAGTGCTGCTCAGT GAACATTTAATAATTTATTACTTTCTAACTCGTTTCTTGTTGACCTCAAGAATTGTACAT AGTCATTAACTTTCCTAAGAAAATCTTTGACAAACATAGAGCTCCTGAGATATTTCACAA CCAGGTGGTCTCCTCCCTGTCCTATGCAATGTTGGGCCCCAGCCTGATTTAGCCGACCTG GTCTTCAGACTTGAGAGGCTGTTTAGGGTTCTTACAACACAAAGGGGATGAGACTTTATC CTCTACCTGTCTGCCAACAAGGGATTCTTCTTATCTCCTTGGTGCAACTTGTCTGAAAAA GAAAGTCAACACAATTATCTTCTTAAAAGTTAAAGATCAAATTAAAAATAAGCTATAGTT TTCCCAAAGATTTAGACCTGAGAAAAAGGAATAGATCTTTCTAAAACCTGGCCTGCACTT AGAGCATTTGTAGTCACTTCCACTATTTCTTATGCTGAGAGAATAATTTGATGTCATGCC TATTGAATGTCTTTCTAAAGCTTGATTCATCAGGAGGAACTGACCAGAAGTCCATGCACA GACATTTGGCTTTCACTGTAATTCCTACTCAAAACTCCCTTTCACTGATTATGAGCAGGT TGCTTAGCTAAAATGAGAAATACAGCAAGAAGAGGGATGGAAAGAGCTGGCTTAAACTTT CCCAAAGACATCATGAACACTGGGAACAGGTCATACATATACCATTTTTATTTCTCAGTC CTCAGTATTAGAATATTGTGTTCCTAGAGGCTTTGTGAAAATTGGAATACATTGCCATGA CCTGCACAGGATAGAGGTGGTTAATATGGCTTACCTTGCTTGTAGATGTTTACTCTTGAT CCCTAAGGGAAACTGGAAGGAAAGCATGCTGTAGAGAGGACCTGCTTTGAGAGTATGTGT CCTCTGGGACAAGTGGAATGAAAGAGAGGATAGAGGCAAAGAGAAAAAAAGGTGGAGATG GGGTGAGACTTGCTGGTGGACAGTTGCAAAGAAAACTCATGATGAGAATAACATCACATT TCTTGAAGAAGCTGAACTGCATTGATGGGAAGTTGAGGCAGAGTTTGAAAAGAAGATATA CTGTCTGCAAAAAAGAATCAACGGAGATGTCAGGTATCTTGATGCACCCTGAGTCTATGA GATGCAGCTTAATTTAATTTAGTGATATGAGTAGGCCATTTCATAAGTGGTGGAAATTAC CATAAAGTGTTTGCAGCTAATGACGGCGCATGAATGATGTCATAGGAACCTAAGTCTGGA TGAGCTATGGATTGAATTTTTACTATGGGACACCCTTCTACATGTTGCTGTGGAAAAGAA TTGTCCTCAAGAAATGTACATCTTCTGCATTTCCTCTACATCTCTGATATTTACAAAGTG CACATTATTTGGTGATACTACAACTGGGATTTCAAGTGCACATCACTACTATTTCCTTCA CTGAAGAATCAAGAGCAGTCTGGGGGTGGGGAGAGCTTGAGTGATTGACAAGGATGTGGC AGAGCCCTGGTTCCACTATGAATTATAGTTCTTACCCTGCTTACTGTCACTCATGTAGAG CAGCTAGTGTGCCTCAGAGCACTGCTGTTCTCTGAGAAGCTGAGGTCTCGATTGACATTC TTGAAGTTGGTGTTTACTTCTCTCTGAATAAACAAAGGTTGGCAACTCAGACATCTTACA ATAAGTACTAAAGATTTTTGAAGAATAGGTTTTTAAAAAATGAAAAAACATTTCACTTTC CATAGCTAATAAATCTTATTTTGAGGAAAATGTACTTTTCTTTAAAAAAAAAAAAAAAGC CTGTCTGTCACTCTAGACCCTTTGGCTTAGAAGGTAGGCACACTCACATAGAAACAGAAA GTCTGTCCAAATTAAAACTGAAAACCACAGTTGACTAATTTTGAATTTATAGCTCTGCTG TTGGCTTCTGCGATAGTATTAATTTCAATGGCTTCAATTAGAAAATGAAACCCATAGCAT TCCATATGAGAACAGGTAAAAAGTCAGGGACATTTGGAGTTTTCCAAGAAAAAGAAAGAC AAGTCTTAGGAAGCTCTCTAGGATGGAAGGAATTTGCCACACTGAGAGTTAGACATCCAA AGGATAGCAATTGGCTCTTCTGCTCATGGGCACTGGTGAAGGCATTTTAAAATGCGAAGA ATGGTACCTCTGTAAATCAATGAGGTTCATAATAATCATGCATTTACCAAATTTTTATAA GCACCTGCCTTGTGCCAGGCACTGAGGGTAAGGTGATGAATAAGCCCTCATCAACTGTCA GACTAGATATTTACTCAATAACAGATGTGAAAATGCCAAGAAGGAAAAGTTGAGTATAAA GAAAGCCTTAAGTTGGTTCAGAGAAATAAAATTGCATTTTTCGGATAGATGTTTATGGAA TCGGCCTTATGAGGTAAACTTGTCCTATGCAGTGAACATACATTCCCAGTTAGTCTCAGA TTGGCCTCTGTGATGACAAACTCAGAGGGTCCTGGTCTAGGAGGGGTGAATTTGTCTGGA GGCCATTTTCAGGAGGTATGGAGGAAGACTGGGGCATAGGCCTGGGGCCATCCCATGTAC TCCTCCTCTGAAATGGGGAGCAACTGAATTGTGTTTTATTTTAGATCTTCGTCCAACTTG AATACCAGAAATTCGTGAAACCTTCTCAAATTCACACTATATTTTGAGACCAGGAGAAGG CTCCTTGAGAAATTGCCACACTGTCTTATCCTAGTCTCTGGAAAAATTCAGTCCTGTATT ATAACTGGGCGTTTCTCATAAGTGCTTTTTTTTTTTCTTTTTCTTTTTATAATACTTTAA GTTCTGGGATACATGTGCAGAATGTGCAGGTTTGTTACATAGGTATACACGTGCCATGGT GGTTTGCTGCACCCATCAACCCATCATCTACATTAGGTATTTCTCCTAATGCTACCCCTT CCCTAGCCCCCCACCCCTCGACAGGCCCCAGTGTTTGATGTTCCCCTCCCTGTGTCCATG TGTTCTCATTGTTCAACTCCCACTTATGAGTGAGAGCATGCGGTGTTTGGTTTTCTGTTC CTGTGTTAGTTTGCTGAGAATGATGGTTTTTGGCTTCATCCACGTCCCTGCAAAGGACAT GAACTCATCCTTTTTATGGCTGCATAGTATTCCATGGTGTATATGTGCCACATTTGCTTT ATCCAGTCTATCATTGATGAGCACTTGGGTTGGCTCCAAGTCTTTGCTATTATGACTAGT ACTGCGATAAACATGTGTATATGTGTCTTTATATTAGAATGATTTATAATCCTTTAGGTC TATACCCAGTAATAGGATTCCTGGGTCAAATGGTATTTCTGGTTCTAGATCCTTGAGGAA TTGCCACACTGTCTTCCACAACGGTTGAACTAATTTACACTCCCACCAACAGTGTAAAAG CATTCCTATTTCTCCACATCCTCTCCAACATCTGTTGTTTCCTGACTCTTTAATGACGGC CATTCTAACTGGCGTGAAATGGTATCTCATTGTGGTTTTGATTTGCATTTCTCTAATGAC CACCGATGATGAGCTTTTTCTCATATGTTTGCTGGCCCCATAAATGTCTTCTTTTGAGAA ATGTCTGTTCATATCCTTTGCCCACTTTTTGATGGGGTTGTTTGCTTTTTTCTTGTAAAT TTGTTTGAGTTCCTGGTAGATTCTGGATATTAGCCCTTTGTCAGATGGATAGACTGCAAA AATTTTCTCCCATTCTGTAGGTTGCCTGTTCACTCTGATGGTAGTTTCTTTTGCCATGCA GAAGCTGTTTAGTTTAATTAGATCCAATTTGTCAGTTTTGGCTTTTGTTGCCATTGCTTT TGGTGTTTTAGTCATGAAGTCTTTGCCCATGCCTATGTCCTGAATTGTATTGCCCTGGTT TTCTTCTAGGATTTTTATGGTTTTAGGTCTTACATTTAAGTCTTTAATCCATCTTGAATT AATTTTTGTATAAGGTGTAGGGAAAGGGTCCAGTTTCAGTTTTCTGCGTATGGCTAGCCG GTTTTCCCAACGTTATTTATTAAATAGGGAATCCTTTCCCCATTGCTTGTTTTTGTCAGG TTTGTCAAAGATCAGACGGTTGTAGATGTGTGGTGTTATTTCTGAGGCCTCTGTTCTGTT CCATTGGTCTGTATATCTGCTTTGATACCAGTACCGTGCTGTTTTGGTTACTGTAGCCTT GTAGTACAGTTTGAAGTCAGGTAGCGTGATGCTTTGTTCTTTTTGCTTAGGATTGTCTTG GCTATATGGGCTCTTTTTTGGTTCTATATGAAATTTAAAGTAGTTTTTTCATAGACATCT ATAGAACTCTCCACCCCAAATCAACAGAATATACATTCTTCTCAGTATCGCATCGCACTT ATTCTAAAATGACCACATAATTAGAAGTAAAACACTCCTCAGCAAATGCAAAAAACAGAA ATCCTAACAGTCTGTCAGACCCCAGTGCAATCAAATTAGAACTCAGGATTAAGAAACTTA CTGAAAACCACACAACTGCATGGAAACTGAACAACCTGCTCCTGAATGACTACTGGGTAA ATAACAAAATTAAGGCAGAAATAAATAGGTTCTTTGAAAGAAATGAGAACAAAGACACAA TATACCAGAATCTCTGGGACACAGCTAAAGCAGTGTTTAGAGGGAAATTGATAGCACTAA ATGCCCACAGGAGAAAGCGGGACAGATCTAAAATCGACACCCTAATATCACAATTAAAAG AACTAGAGAAACAAGAGCAAACAAATTCAAAAGCTAGCAGAAGACAAGAAATAACTAAGA TCAGAGCAGAACTGAAGGAGATAGAGACACAAAAAACCCTTCAAAAAATCAATGAACCCA GGAGCTGTTTTTTTTTTTTTTTTGAAAAGATTAATGAAATAGACTGCTAGCCAAACTAAT AAAGGAGAAAAGAGAGAAGAATCAAATAGACAATAGACACAATAAAAAGTGATAAAGGGG ATATCACCACTGATCCCACAGAAATACAAACTACCATCAGAGAATACTATAAACACCTCT ACGCAAATAAACTAGAAAATTGGGAAGAAATGGATACATTCCTGAACGCATACACCCTCC CAAGACTAAACCAGGAAGAAGTTGAATCCCTGAATAGACCAATAGCAAGTTCTGAAATTG AGGCAGTAATTAGTAGCCTACCAACCAAAAAAAGCCCAGGACCAGACAGATTCACAGCCG AAGTCTACCAGAGGTACAAAGAGGAGCTAGTACCATTCCTTCTGAAACTATTCCAAACAA TAGAAAAAGAAGGACTCCTCCCTAACTCATTTTATGAGGCCAGCATCATCCTGATACCAA AACCTGGCAGAGACACAACATAAAAAAGGAAATTCAGGCCAATATCCCTGATGAACATTG ATGTGAAAATCCTCAATAAAATACTGGCAGCACATCAAAAAGCTTACCTGCCATGATCAA GTTGGCTTCATCCCTGGGATGCAAGGCTGGTTCAACATACGCAAATCAATAAACGTAATC AATCACATACACAGAACCAATGACAAAAACCACATGATTATCTCAATAGATGCAGAAAAG GCCTTCGATAAAATTCAACACCCCTTCAATGCTAAGAACTCTCAATAAACTAGGTATTGA TGAAACATATCTCAAAATAATAAGAGTTATTTATGACAAACCCACAGCCAGTATCATACT GAATGGGCAAAAGCTGGAAGCATTCCCTTTGAAAACCGCCACAAGGATGACTTCTCTCAC CACTCCTATTCAACATACTATTGGAAGTTCTGGCCAGGGCAAGCAGGCAAGACAAATAAA TAAAGGGTATTCAAATAGGAAGAGAGGAAGTCAAATTGTCTCTGTTTGCAGATGACATGA TTGTATATTTAGAAAACCCCATCATCTCAGCCCAAAATCTCCTTAAGCTGATAAGCAACT TCAGCAAAGTCTCAGGATACAAAATCAATGTGCAAAAATCACAAGCATTCCTATACACCA ATAATAGACAAACAGCCAAATCATGAGTGAACTCCCATTCACAAGTGCTACAAAGAATAA AATACCTAGGAATCCAACTTACAAGGGATGTGAAGGACCTCTTCAAGGAGAACTACAGAC CACTGCTCAAGGTAATAAGAGAGGACACAAACAAATGGAAAAACATTCCATGCTCATGGA TAGGAAGAATCAATATTATGAAAATGGCCATACTGCCCAAAACAATTTATAGATTCAATG CCATCCCCATCAAGCTACCACTGACTTCCTTCACAGAATTAGAAAAAAACTACTTTAAAT TTCATATGGAACTGAAAAAAGAGCCGGTATAGCCAAGACGATCCTAAGCAAAAAGAAAAA AGCTGGAAGCATCATGCTACCTGACTTCAAACTATACTACAAGGCTACAGTAACAAAAAC AGCATGGTATAGTATAAGTGCTTTTTTTTAAAAGACAAAGTAAAGTAATTTTTTTGTTGT TGGGGTAAAACAAAAGCTCTGCATAAAGAGCAGGGATGTTGTAACATACACTGACCAAAG GTGGGAAACCTACAGTTGGAGCAGAAGCTGAATGTCACATTATCAGCTCCGAACTTATAA TGGTCTAAAAGTACTAGGTTAATGTTGGAAAGATGGTGCCATTTAAAGATATCTTAAATT CAATATTTAATTATTTTAATTTGACATTATCCTAGAGTTGAATGGTGTTTACTTACCATG TGCTGTTCATTAGAAAATCTAGATCCTACACTGCCTTTGCGCAAGGTAGTTGCTCTAATA ATACCAACCTGTCCAGTTTTGGTGGGAGAAATAATGTTACTGTTAAGTTGCACTTAGTGG TTATTATGTGTAATACTGGTATTCCAAAGAGAGAAGGAAAATGTTTGCTACACAGCTGTG TTCTTAGGTTCAGAAAACCACAGGAGTGGGACAGGAGAACCTTCAGGATTCAGGTCCGAT TGTTGTGATGGCCGCAGGAGGGAGACTGTGAATTTGAAACTGCATCCATTGAAAAGAAAA TCCCTCCACACTTTAATAATTCTCTCCGTGCCCCATGGCAGCAAGTGCTTATAGGCCTTG CTACTCAAAGCTTAATAAAAAGGCAGACCTGCTGAATCATAATCTGCATCTTAACAATAT CCCCAGATATTGTCTGCACTTTCTTTTTTTTTTTCTTTCTTTCTTTCTTCTTTTTTTTGA GACAGAGTCTCGCTCAGTCACCCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCACTGCA AGCTCTGACTCCCGGGTTCACGCCATTCTCCTGCCTTAGACTCCCGAGTAGCTGGCACTA CAGGCGCCCGCCACTACGCCCGGCTAATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCA CCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCGCCCATCTGGGCCT CCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCAATTGTCTGCACTTTCA AGTCTAAGAAGCACTGTCCCAGGAGGAAAATCTTTTTAGTCTGTCTGAGGCTTCTCTCTT GCACTCTCCTTTTTAAAAATATGCTGCTCCTTCTCCACCTTTCCCTCTTCTTCCGCCTTT TCTGTCTGCCTTTACTACCTCCCCTGAACATTCAACTTGTAGAAGAGTTCCCCTTTCTCT GAATTGCATTCTTCACTTCATTCATTCTTTTCTCTCTCTGTCTATGGTTTCCTATTTTTT GTCGGTTTTCCCTCACCTCACCTCCTTGTTATTTTTTGCCATTGTTCACATATCACTGCC CTTTCAGACCCATATCTAGCTTCTGACCCATCCACTAATCCATTGCCACTAATTTATTCA GCATGCCCATGCCATTTATTAATGTAAATATTTGCACATACTTGTTCTATCATGCCCATT TTTCTACCTTTTAAATTGTATATACACAGACACATGTGAATGACATATTTCACTATTTAA AAGGTAGAAAAATGTATATCGTGGTACAAAGTGATACATTGAGTATCTGTGCCCAGTTTC AAGATGAGAATAAGTGAGAGGTGAAGCCTCATGAGTCACGTCACCTACACGCTACTGTCT TTCATTCCATCTGCAGTACTGCCACACATTTGGTTAGTTCTCCAATTGCTGTCACATTGA CATCGAGTTGGATCTGAACAGCGTACCTGGGGAGACGAAGTATTGGTATCTTTGCTTAAA TGGAGTGATTTACTGAGAGACAAAGTGACATCTTTAAGATCAGATAGCAAGTTACTGCAC CAGGAGCGCGACCTTTCCTGTTTTGTTGTTTTCCCTCTGTCAAATGCCTTCTGGTCTCCA TGAATCTCTCCTTCCACATATGATAAAAATGCAAAGTCTCATAAGCATTCACAGCTCAGG AAGCCTCAGGCTAGTTGGGGAGAAAAGACTGGGAGGTTTCCGGAGGAATGAAGTCCTCTG AGCAGAGAGGTTAATTCATCTTGCTGTAAAACAAAATAGAAAATAAGTTCCCCTCAATAA GTGAACGTAATACAAAGACAAATGTGGTTGGTGCCAGAGGCCAGGAAGAAGTTCTTGTGA GAATAGGTGCAGAGAAGAGCTAGGCCCTGGCTGAGTTTAAACCTTGACTTAGTCACTGTG GGACTCTGGGTGAGTTACTCCATGGATTGATGGCTGGGTCATGGAGATAATAGTACCTAA TTCATACAGGTACTGTGAGAAGTAAATGGAATATTTCACGTTAAGTGTTTAACGGTGCGT TTAAATGCTAGGTGCTATTATTATTAATTTTTAAATTAACTTTGCCATGTTTTGTGTCTT CCCCTCTCTGTGCTTCCTTTCTTTAGTATGAGCCGCACAGCCTACACGGTGGGAGCCCTG CTTCTCCTCTTGGGGACCCTGCTGCCGGCTGCTGAAGGGAAAAAGAAAGGGTCCCAAGGT GCCATCCCCCCGCCAGACAAGGCCCAGCACAATGACTCAGAGCAGACTCAGTCGCCCCAG CAGCCTGGCTCCAGGAACCGGGGGCGGGGCCAAGGGCGGGGCACTGCCATGCCCGGGGAG GAGGTGCTGGAGTCCAGCCAAGAGGCCCTGCATGTGACGGAGCGCAAATACCTGAAGCGA GACTGGTGCAAAACCCAGCCGCTTAAGCAGACCATCCACGAGGAAGGCTGCAACAGTCGC ACCATCATCAACCGCTTCTGTTACGGCCAGTGCAACTCTTTCTACATCCCCAGGCACATC CGGAAGGAGGAAGGTTCCTTTCAGTCCTGCTCCTTCTGCAAGCCCAAGAAATTCACTACC ATGATGGTCACACTCAACTGCCCTGAACTACAGCCACCTACCAAGAAGAAGAGAGTCACA CGTGTGAAGCAGTGTCGTTGCATATCCATCGATTTGGATTAAGCCAAATCCAGGTGCACC CAGCATGTCCTAGGAATGCAGCCCCAGGAAGTCCCAGACCTAAAACAACCAGATTCTTAC TTGGCTTAAACCTAGAGGCCAGAAGAACCCCCAGCTGCCTCCTGGCAGGAGCCTGCTTGT GCGTAGTTCGTGTGCATGAGTGTGGATGGGTGCCTGTGGGTGTTTTTAGACACCAGAGAA AACACAGTCTCTGCTAGAGAGCACTCCCTATTTTGTAAACATATCTGCTTTAATGGGGAT GTACCAGAAACCCACCTCACCCCGGCTCACATCTAAAGGGGCGGGGCCGTGGTCTGGTTC TGACTTTGTGTTTTTGTGCCCTCCTGGGGACCAGAATCTCCTTTCGGAATGAATGTTCAT GGAAGAGGCTCCTCTGAGGGCAAGAGACCTGTTTTAGTGCTGCATTCGACATGGAAAAGT CCTTTTAACCTGTGCTTGCATCCTCCTTTCCTCCTCCTCCTCACAATCCATCTCTTCTTA AGTTGATAGTGACTATGTCAGTCTAATCTCTTGTTTGCCAAGGTTCCTAAATTAATTCAC TTAACCATGATGCAAATGTTTTTCATTTTGTGAAGACCCTCCAGACTCTGGGAGAGGCTG GTGTGGGCAAGGACAAGCAGGATAGTGGAGTGAGAAAGGGAGGGTGGAGGGTGAGGCCAA ATCAGGTCCAGCAAAAGTCAGTAGGGACATTGCAGAAGCTTGAAAGGCCAATACCAGAAC ACAGGCTGATGCTTCTGAGAAAGTCTTTTCCTAGTATTTAACAGAACCCAAGTGAACAGA GGAGAAATGAGATTGCCAGAAAGTGATTAACTTTGGCCGTTGCAATCTGCTCAAACCTAA CACCAAACTGAAAACATAAATACTGACCACTCCTATGTTCGGACCCAAGCAAGTTAGCTA AACCAAACCAACTCCTCTGCTTTGTCCCTCAGGTGGAAAAGAGAGGTAGTTTAGAACTCT CTGCATAGGGGTGGGAATTAATCAAAAACCTCAGAGGCTGAAATTCCTAATACCTTTCCT TTATCGTGGTTATAGTCAGCTCATTTCCATTCCACTATTTCCCATAATGCTTCTGAGAGC CACTAACTTGATTGATAAAGATCCTGCCTCTGCTGAGTGTACCTGACAGTAGTCTAAGAT GAGAGAGTTTAGGGACTACTCTGTTTTAGCAAGAGATATTTTGGGGGTCTTTTTGTTTTA ACTATTGTCAGGAGATTGGGCTAAAGAGAAGACGACGAGAGTAAGGAAATAAAGGGAATT GCCTCTGGCTAGAGAGTAGTTAGGTGTTAATACCTGGTAGAGATGTAAGGGATATGACCT CCCTTTCTTTATGTGCTCACTGAGGATCTGAGGGGACCCTGTTAGGAGAGCATAGCATCA TGATGTATTAGCTGTTCATCTGCTACTGGTTGGATGGACATAACTATTGTAACTATTCAG TATTTACTGGTAGGCACTGTCCTCTGATTAAACTTGGCCTACTGGCAATGGCTACTTAGG ATTGATCTAAGGGCCAAAGTGCAGGGTGGGTGAACTTTATTGTACTTTGGATTTGGTTAA CCTGTTTTCTTCAAGCCTGAGGTTTTATATACAAACTCCCTGAATACTCTTTTTGCCTTG TATCTTCTCAGCCTCCTAGCCAAGTCCTATGTAATATGGAAAACAAACACTGCAGACTTG AGATTCAGTTGCCGATCAAGGCTCTGGCATTCAGAGAACCCTTGCAACTCGAGAAGCTGT TTTTATTTCGTTTTTGTTTTGATCCAGTGCTCTCCCATCTAACAACTAAACAGGAGCCAT TTCAAGGCGGGAGATATTTTAAACACCCAAAATGTTGGGTCTGATTTTCAAACTTTTAAA CTCACTACTGATGATTCTCACGCTAGGCGAATTTGTCCAAACACATAGTGTGTGTGTTTT GTATACACTGTATGACCCCACCCCAAATCTTTGTATTGTCCACATTCTCCAACAATAAAG CACAGAGTGGATTTAATTAAGCACACAAATGCTAAGGCAGAATTTTGAGGGTGGGAGAGA AGAAAAGGGAAAGAAGCTGAAAATGTAAAACCACACCAGGGAGGAAAAATGACATTCAGA ACCAGCAAACACTGAATTTCTCTTGTTGTTTTAACTCTGCCACAAGAATGCAATTTCGTT AACGGAGATGACTTAAGTTGGCAGCAGTAATCTTCTTTTAGGAGCTTGTACCACAGTCTT GCACATAAGTGCAGATTTGGCTCAAGTAAAGAGAATTTCCTCAACACTAACTTCACTGGG ATAATCAGCAGCGTAACTACCCTAAAAGCATATCACTAGCCAAAGAGGGAAATATCTGTT CTTCTTACTGTGCCTATATTAAGACTAGTACAAATGTGGTGTGTCTTCCAACTTTCATTG AAAATGCCATATCTATACCATATTTTATTCGAGTCACTGATGATGTAATGATATATTTTT TCATTATTATAGTAGAATATTTTTATGGCAAGATATTTGTGGTCTTGATCATACCTATTA AAATAATGCCAAACACCAAATATGAATTTTATGATGTACACTTTGTGCTTGGCATTAAAA GAAAAAAACACACATCCTGGAAGTCTGTAAGTTGTTTTTTGTTACTGTAGGTCTTCAAAG TTAAGAGTGTAAGTGAAAAATCTGGAGGAGAGGATAATTTCCACTGTGTGGAATGTGAAT AGTTAAATGAAAAGTTATGGTTATTTAATGTAATTATTACTTCAAATCCTTTGGTCACTG TGATTTCAAGCATGTTTTCTTTTTCTCCTTTATATGACTTTCTCTGAGTTGGGCAAAGAA GAAGCTGACACACCGTATGTTGTTAGAGTCTTTTATCTGGTCAGGGGAAACAAAATCTTG ACCCAGCTGAACATGTCTTCCTGAGTCAGTGCCTGAATCTTTATTTTTTAAATTGAATGT TCCTTAAAGGTTAACATTTCTAAAGCAATATTAAGAAAGACTTTAAATGTTATTTTGGAA GACTTACGATGCATGTATACAAACGAATAGCAGATAATGATGACTAGTTCACACATAAAG TCCTTTTAAGGAGAAAATCTAAAATGAAAAGTGGATAAACAGAACATTTATAAGTGATCA GTTAATGCCTAAGAGTGAAAGTAGTTCTATTGACATTCCTCAAGATATTTAATATCAACT GCATTATGTATTATGTCTGCTTAAATCATTTAAAAACGGCAAAGAATTATATAGACTATG AGGTACCTTGCTGTGTAGGAGGATGAAAGGGGAGTTGATAGTCTCATAAAACTAATTTGG CTTCAAGTTTCATGAATCTGTAACTAGAATTTAATTTTCACCCCAATAATGTTCTATATA GCCTTTGCTAAAGAGCAACTAATAAATTAAACCTATTCTTTCTGTG OMIM ID 603054