Entrez gene ID | | 2668 |
Official gene symbol | | GDNF |
Full name | | glial cell derived neurotrophic factor |
Aliases | | ,ATF1,ATF2,HFB1-GDNF, |
Gene summary | | This gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene may be associated with Hirschsprung disease. [provided by RefSeq] |
Location | | Chromosome: 5 Locus: 5p13.1-p12 |
Gene position | | 37839782 - 37812779 Map Viewer |
Gene orientation | | minus |
Gene size | | 27004 bp |
Gene sequence |
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OMIM ID | | 600837 |
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