Database of mammalian genes
Home

Home Search Browse Statistics User guide FAQs Links Questions Contribute Download


Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for GIPR (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID2696
Official gene symbolGIPR
Full namegastric inhibitory polypeptide receptor
Aliases,MGC126722,
Gene summaryGastric inhibitory polypeptide (GIP; MIM 137240), also called glucose-dependent insulinotropic polypeptide, is a 42-amino acid polypeptide synthesized by K cells of the duodenum and small intestine. It was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release potently in the presence of elevated glucose. The insulinotropic effect on pancreatic islet beta-cells was then recognized to be the principal physiologic action of GIP. Together with glucagon-like peptide-1, GIP is largely responsible for the secretion of insulin after eating. It is involved in several other facets of the anabolic response.[supplied by OMIM]
LocationChromosome: 19   Locus: 19q13.3
Gene position46171502 - 46185717  Map Viewer
Gene orientationplus
Gene size14216 bp
Gene sequence
OMIM ID137241