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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for APEX2 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 27301 Official gene symbol APEX2 Full name APEX nuclease (apurinic/apyrimidinic endonuclease) 2 Aliases ,APE2,APEXL2,XTH2, Gene summary Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair (BER). [provided by RefSeq] Location Chromosome: X   Locus: Xp11.21 Gene position 55026780 - 55034212  Map Viewer Gene orientation plus Gene size 7433 bp Gene sequence >APEX2:2580866..2588298:Length=7433 TGGCCAACTTCTGAACAGGAAGCAGTTCGCTCGCGCCTAGGTTGGCGCGGGCTGGGAGGT GTTCCAGCCCTTTAAGATGTTGCGCGTGGTGAGCTGGAACATCAATGGGATTCGGAGACC CCTGCAAGGGGTGGCAAATCAGGAACCCAGCAACTGTGCCGCCGTGGCCGTGGGGCGCAT TTTGGACGAGCTGGATGCGGATATCGTCTGTCTCCAGGAAACCAAAGTGACCAGTGAGCG CTCTGGATTCCAGGATCCCTACATACTTTTTCTTTCCCGCTAACTTTTGTCCCCTGTCCC ATGTAATTTTACTTTCCCAGTTTCCTATTCTTAGAGTCCTGTCCTTAGACCCAGGTCCCT TCCCTCTTAAACTTCCATTTCCCACCCTAGCTAGATCCCCTAATTGCACTCCATCTCCTG TCTTCAGCAAACTTTAGCTCCTTCTCGAAACCCCATATCTAGTCAGATTCCCACTCATTC TCCGGCCCCAAACTCAGTCCCCTGAATTTCCTCCTTCCATACGCTGTCCATCTCCCCGCC GCCAAGTCAAACCCCCGAATTCTTCATCCCTGCCCCAAGCTCAGATCCTCTAATTCCCAC CCCATCTTTGACCCCAGCTCAGTCTAATTTCCTCTTTTTCACATTTCCACCTCAGAACCC CAGTACCCCTTATCTATTCCCATCTCTCCTCCCAGCGGAAAGTCCCTAATTCCCACCTCA TTTCCCACCCCAAGCTTAGATGTCCTCTTATTTCTTCACCCTCTTATCTCCCCTCAGAAT CCCCTAATTCCTTTTCCCTCCACCCCCAGTTCAGATCCCCTAATTCCCTCTCTCTTACCT CTCACCCTTAGCTCAGATTCCCACCATCCTCTCGTATGTCCATCCCCATCCCCAGCTTCC TCCTATCGTTCAGACCCCCAGGCTTAGCTCTGATTCTTTCCCCTTCCCACCTAATTCTCC ACCTCCACTTCATAGTCTCTAACCGCCCCCCACCAAGCCTTCTAATTCTGATATCAATTT CCTCTCTGACATTTCCCATCTTTCTAGGTCCTCCTCTAATCATGGATATTTCATTCCCGT CACCCCCAACTCTGGCTCTGATGTGTGCAAGGAATTAGCCTACAACTGTAATTCCAGGCC TTTGTGTTTCTCGGATGCTAGTTTTACCTCTGACTTAATCTTACATTTTTTTTTTCCAGG GGATGCACTGACAGAGCCCCTGGCTATCGTTGAGGGTTATAACTCCTATTTCAGCTTCAG CCGCAACCGTAGCGGCTATTCTGGTAAATGGGGCTTTCTGTGGACTTTAAATTAGTGAGG GAGGCAGATAGGGGAAAAGGGTTTCCAATATTTGATGAGAGGGTAATAAGAAATCTTAGA CATTTAGTTTACAGAGCTAAAGCTGCATAATAGTAAATTACATGAAATATAATTTTTATG GATAGAATTATCCTACTGGACCTCAGAAGTACAGTAGTAGTGTGGTGCTTAATTGTGTGA ACTGTGGAGCCAGACAGCCTGGGTTTGAATCATGGCTCATTTCCTAGCTGTGCACCCTCT GGCAAGTTACATTACCTCTTGGTGCCTCAGGTTCCTCAGCTAGAAAATGAGGATAATGTT TACCTTCCGGGGCTGTTACAAGGATTAAATGAATTAATCCATGTGATAATAATAATTGCT AATACGTCTTGAGCACTCACCATGTATCAATGTAAAACACTTAGAACATTCTGTGGCTTT TTTAGATGTAGGAACTGAGACTCCAGGGTTTGAATAAGGTTGCCCAAGAACCACACTTTA TGAAGATGACTTAGATGACTTGTGTGGGGACAATTGGAGTGGGACAGGCTGTGCAACAGG CTATTGACTGCCAGGTCTGCTCAGAGTGCCCTGTCTGTTCCCAGGTGTAGCCACCTTCTG TAAGGACAATGCTACCCCAGTGGCTGCTGAAGAAGGCCTGAGTGGCCTGTTTGCCACCCA GAATGGGGATGTTGGTTGCTATGGAAACATGGATGAGTTTACCCAAGAGGAACTCCGGGC TCTGGATAGTGAGGGCAGGGCCCTCCTCACACAGCATAAGATCCGGTAATAGCTCATATC TCCCTGCTACTGAGCACTGCTGGTGCTACTCTTTGAGTGTGAAGATTCTAAGGCTTGCCA TGTAAACATACATGCACCGTGGAGAAGTTCCCAAATTTGCCTTTCCTGGTTTAGTCCTGG CTGGGCTACTCAGTGTGTGACCCTGGCAAATTTTTCCCCCCTCTGAAGCTTGAGTTTCCA TCTCTACAATGTGGGGCTGGCCTAGTGATCCAGCTCTTATTACCATAGACATCTCAAAAG CAACTTAGTGCTGAACTCAGTGCCCCAGGTTGCTGTCTTTCTGGGTGTTCTGTGTGAATA GCAGCACCATTACCTGGTGGTAATCCTTAGATATCCCTCTCCCTGCCTTATCAGTAGTCA GTCCCCAAGTCCTGTGCATGCCAGATCATTTGTGTCTCTTTAACCCCTTTCTTTTCCATC CCAGACAGTCACAAAATGGAAGCCATGTGGTATGGGGAAGGGACAGAAGGGGAGGTTTGA AACTGACCCCTTTTGGGGGTTTCTCTTTTCTCCAGCACATGGGAAGGTAAGGAGAAGACC TTGACCCTAATCAACGTGTACTGCCCCCATGCGGACCCTGGGAGGCCTGAGCGGCTAGTC TTTAAGATGCGCTTCTATCGTTTGCTGCAAATCCGAGCAGAAGCCCTCCTGGCGGCAGGC AGGTACTGCAAGCCTGGGCAGTAAGGCTTCCTTGAGTTGGTCCTGGGTGCCCAGCCCTGT GTCAAGCTCCATTGAAAGGGATATGGACCCTTTGTCTCTGAGTTCTTTCACAGCATAGTT GCAAACACCAATATGCCCACCTGAATAGGCTCTGCTCAAAACAAACATGGGTTTTGTACT CTGAGCACCTATTCAGGCTCCTGCTCTTACTCATTGTGAGCCCTAGGGCTAGTCTTGCCT CTGTTTTCTCTTTTGTCAAATGAATATATGAATCTCTACCCTACACAATAGTTTTAAGGG TAAAATGAGATGAGAATGGTAAAGTGCGTGGGAGCAAAGGAAAGTCTTGTTCCAGCGGAG GACAGGAAAGTGAGGGTGGGTTAGAGCAATCAAGGGGAGGTGGTATCTGAGCTCAGCTTT GAAGGACAAGAAAAATGCCCATTGGCTCCTGATTAGTGAGGCAGTCATGTCAAACATGGA ACACTGTCACCTTTGGAGATCAGAATTGGGTTGGTCAGATATGAAAGGCAGCAAGTTTGT GGTAAGATTGGAGAGGTAGGCTGTTATGAGTTGCTGTTGGCTAGGAAGCCTCAATATGGG AGAGGGCCTGTCTGAGCTCTTGGGCCCAGGAAAAAGTATATGGGCCAGGACTGCTGCACC CCTTTCTAACAATCCCACATTGTGTTTTTCAGCCATGTGATCATTCTGGGTGACCTGAAT ACAGCCCACCGCCCCATTGACCACTGGGATGCAGTCAACCTGGTAAGGCTCCCTCTAGGT GCCTGGCCCCACTCCTGACTGATTCTGTTTGTCCAGCCAACCAACCCTGAGTTTTTGGCC CAGGGACAGCTTCCTTTATGGGAAAGCGGAGCTTGGCTTGCAATACTATTCTTATAGTAC TGAGGATTGGTCATTCATTCAATAGACAATACTGACTCTGCCCATGGCCTGGCCCTGAGC CACATACTGAGGACTCAGGAGTCAGATCCAGCCCTTGGCTCCTAGGAGCTCTCCAGCATG GTGGTGGGCTACAGACACATGGCTAGCCAATTATAGGATGGTATTCTCAGGGCAGAGGCA CAGATGGCATCCCAGAAAGCTACAGGAGCTCAGAGATGGGATTCCTAGGTGAGCTCGGAC ATCAGGACAGGCAGCTGAAAATGGCTGAATCTTAACAGATGAGTAGAACAGAGCTTTGAA GTAGAAAGCATTCTAGCATGGGCAAAGGTTTCAAGGTGAGAATTTGCATTGTGTGCATGG GGAACCACAAGTCCCTTTCTTCTTAGTGACACAGGAAGGGAGGTGAGTGGCAGAAGGTGG GGCTGGAGAGTTGTTGGGGGTCAGATTTCAAGGACTGTGAATTCCACATTGCCTTGGTCA TTTCCTTAATACACTGTATTTCTTGTTTATGAACTTTCAGTACCTCCCTGTTACCTCTGT GATGCAGAGAAAACATGGAGACCTAGCATTCAAGGCTCTCCTTGGTCTGTGACCTGTCTC TTATTTCCACCTTCAGTGTCCCTACACATTTTGTCCTCTCTAGACAGGTTGTCTCCTGTC GGCCCGTTGTAAAAGTTATTCTCATTCTGGCTTTTCTCACTGTGCCCTGAATTGGTGGAC ATGACCCCCTCCCTGTCTTTTTGTTATATGAACCTCTTATCTCTAAGTTCCCCTAGGCCC ATGGTTTTCAGCCCCTAACTGCATATTAGAACAAAAATATCAATATCTTAGCACTACTCC AGATCAATGAACTCAGAACTCTCGAGTGTGGGGCCAGGGTAGTGGCACGTTCTAAAAGCC CCCAGTGTGACTTTATTGTGCAGCCAGGCTTGAGAACCACTGCCCTAGAATCCACAAGCC AGCTCTCATCTTTTCTTGCCTTATGTCTCACGATGGGGGATCAGTGATTTATGCTGGTAC AGTCCTACTCAGCACTGGGCTTGGCTTAGAGAAGGGACCGTGGGAATATTCCTTGATTAA TTCACAGAAGAGCTACATAAATGTAGATATGGCTCCCAGCTGGGAAAATGAGCAGAAGTG AGAGAATGAGAGAATGGTGGTGGTGGTGTGGTGGGGAGCGGAGATAATGCTACAAAGTGT GAGCCTTCAGTCCCTCCCTGCCTCATTCCTCTTATGCATTCATTCAGTGTGTTCTTTCAG ATTCCTGTGATAGCATCATACATCTTTGTGCCTTTTCTACTTAGTTCAGAGGTATCCTAG ATCTCTTATGTATACCTCTTTCATTTTCTCCTCCAGGAAAAGAGAACTAATAGTGCCAGC TCAGATGACTTACACAGTCTTTCCAAAATAGCAGAACATACCCACTTTCTACCAGGCTTG CTCTTTTAGTCTTGTCATTTCTGTAAATGGCACCATCATCCCCTTGATTGCTTCAACTTA AAGCCTGGGAATTGTGCTAGTATTGTCTTTCTTTCTTACTCCACTTCCCACATTCAGTTA GTCAGCAAGTACTGTTGATTCTAGCTACAAATCATCTCATAATTTCATGTTTCTGTCTCC TCTGGCACCCACCCTAGTCCAAGTGACCATCATCTTGCTTGTGTGACTATGGCAGCCATT TCCTGCTGGTATTCTGGTCTCCAGTCTGGTCTTTCCTCAAGTCTTTTGGGTACGCAGCAC ACTCCCTCCACAGGCCCAGCACAGAGACTGTTCTTAAAGTTAGGAGCACCCTCCACCTAG GTTACTCTTACTCAGCCCCCACACCTCAGCTCCAGATCACTTCTCGAAAGGAAGCCTCCT TGGTCCCCAGGAGTAGATCAGGTTCCTACTTTGTCCCTGGCATCATGCATGGCACATAAT AGGTATTCCATGAACATTTCTTGCATTGAATGAGTGGGTGGGTAGGTGGATTGAATGGAT GGACTGATGGATGATGGATTGGGGATCAGAGCCTAAGGAAGTATTCAGACCTGGATCCTT GCAGGTCCTCAGCTCAGGAGGTAGGAATGGTCATTGAGGGCTTTGACACACTAGATAAAC CAAATAGTGCCAGAGGGTTTAAAGGAAGAAGCTGACAGTCTTCCTAACTCTTAACCCCAG CCCTGCTTCCTAGAGGCAAACACTTTTAACTTCCTGTTTTCCATCCTTTTGAAAAGCAGT TCCAGGAATTGCTTTGAGTAAGCAAACTTTCAGATTTGCCATTGACGGACCAATGCAAGA CAAATGCAAGCTCGTGCAGAGGGAAAAACAAGCATGGTCTTTTAAATCAGTAAGGATGAA AATCAGAATCCCAGCTCTGCCAATTCCGGACTGTGTGACCTTGAGCAGTAGTCCTCTTGG GACAACCAAATTTTCTTATTTGCAAAATGCAGCAGTTAGTCTAAGTCCCTTCCAGTTCTA GGTATCTAGTTCTGTCTCTCTCTCTTCCAACCCCCTTTCCTCCTCACCTAGGAATGCTTT GAAGAGGACCCAGGGCGCAAGTGGATGGACAGCTTGCTCAGTAACTTGGGGTGCCAGTCT GCCTCTCATGTAGGGCCCTTCATCGATAGCTACCGCTGCTTCCAACCAAAGCAGGAGGGG GCCTTCACCTGCTGGTCAGCAGTCACTGGCGCCCGCCATCTCAACTATGGCTCCCGGCTT GACTATGTGCTGGGGGACAGGACCCTGGTCATAGACACCTTTCAGGCCTCTTTCCTGCTG CCTGAGGTGATGGGCTCTGACCACTGCCCTGTGGGTGCAGTCTTGAGTGTGTCCTCTGTG CCTGCAAAACAGTGCCCACCTCTGTGCACCCGCTTCCTCCCTGAGTTTGCAGGCACCCAG CTCAAGATCCTTCGCTTCCTAGTTCCTCTCGAACAAAGTCCTGTGTTGGAGCAGTCGACG CTGCAGCACAACAATCAAACCCGGGTACAGACATGCCAAAACAAAGCCCAAGTGCGCTCA ACCAGGCCTCAGCCCAGTCAGGTTGGCTCTAGCAGAGGCCAGAAAAACCTGAAGAGCTAC TTTCAGCCCTCCCCTAGCTGTCCCCAAGCCTCTCCTGACATAGAGCTGCCTAGCCTACCA CTGATGAGCGCCCTCATGACCCCGAAGACTCCAGAAGAGAAGGCAGTGGCCAAAGTGGTG AAGGGGCAGGCCAAGACTTCAGAAGCCAAAGATGAGAAGGAGTTACGGACCTCATTCTGG AAGTCTGTGCTGGCGGGGCCCTTGCGCACACCCCTCTGTGGGGGCCACAGGGAGCCATGT GTGATGCGTACTGTGAAGAAGCCAGGACCCAACTTGGGCCGCCGCTTCTACATGTGTGCC AGGCCCCGGGGTCCTCCCACTGACCCCTCCTCCCGGTGCAACTTCTTCCTCTGGAGCAGG CCCAGCTGAACCAATGGAGGCCTGGGGACATCTGGCATGGTCACCCCTGCACATGATCTG AGGCCAGCTCCCCTTCCCTGAGCTGCCTCCTGCTTCTCCCTCAAAGTCTCCTACCCTTCT CTTCCTCTTTTAAGCCCTCTCTTCCTCGCTTTCCTTCCTACCTAGCTCCTTGTTGGTGAG CTTCTTGTGCCTTAATCCTGTGACCCAGCCCCTTACACCACTTTCCACCTTCCTGTCCGA AGTACACGGACACTAGCTGCCCCAGGAAGTTGTGTGATTTTAAATCACTTCTGTCTTTGC TGGAAAGTGTATTTGTGCATAAATAAAGTCTGTGTATTTGTTTCAGGGTTGCA OMIM ID 300773