Entrez gene ID | | 2733 |
Official gene symbol | | GLE1 |
Full name | | GLE1 RNA export mediator homolog (yeast) |
Aliases | | ,GLE1L,LCCS,LCCS1,hGLE1, |
Gene summary | | This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
Location | | Chromosome: 9 Locus: 9q34.11 |
Gene position | | 131266971 - 131304580 Map Viewer |
Gene orientation | | plus |
Gene size | | 37610 bp |
Gene sequence |
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OMIM ID | | 603371 |
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