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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for BIN1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID274
Official gene symbolBIN1
Full namebridging integrator 1
Aliases,AMPH2,AMPHL,DKFZp547F068,MGC10367,SH3P9,
Gene summaryThis gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynanim, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. [provided by RefSeq]
LocationChromosome: 2   Locus: 2q14
Gene position127864864 - 127805607  Map Viewer
Gene orientationminus
Gene size59258 bp
Gene sequence
OMIM ID601248