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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for Abcc5 (Mus musculus)
(Information is obtained from NCBI Gene database)
Entrez gene ID27416
Official gene symbolAbcc5
Full nameATP-binding cassette, sub-family C (CFTR/MRP), member 5
Aliases2900011L11Rik,AI132311,Abcc5a,Abcc5b,MGC116567,Mrp5
Gene summaryThe membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The human protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that the human protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq]
LocationChromosome: 16   Locus: 16 A3|16 14.0 cM
Gene position20426467 - 20331376  Map Viewer
Gene orientationminus
Gene size95092 bp
Gene sequence