| Entrez gene ID | | 27973 |
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| Official gene symbol | | Vkorc1 |
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| Full name | | vitamin K epoxide reductase complex, subunit 1 |
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| Aliases | | D7Wsu86e |
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| Gene summary | | Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the product of this gene that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance. [provided by RefSeq] |
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| Location | | Chromosome: 7 Locus: 7 F3|7 61.0 cM |
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| Gene position | | 135039131 - 135036577 Map Viewer |
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| Gene orientation | | minus |
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| Gene size | | 2555 bp |
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| Gene sequence |
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