Entrez gene ID | | 2821 |
Official gene symbol | | GPI |
Full name | | glucose-6-phosphate isomerase |
Aliases | | ,AMF,GNPI,NLK,PGI,PHI,SA36, |
Gene summary | | This gene belongs to the GPI family whose members encode multifunctional phosphoglucose isomerase proteins involved in energy pathways. The protein encoded by this gene is a dimeric enzyme that catalyzes the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate. The protein functions in different capacities inside and outside the cell. In the cytoplasm, the gene product is involved in glycolysis and gluconeogenesis, while outside the cell it functions as a neurotrophic factor for spinal and sensory neurons. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. [provided by RefSeq] |
Location | | Chromosome: 19 Locus: 19q13.1 |
Gene position | | 34855645 - 34893318 Map Viewer |
Gene orientation | | plus |
Gene size | | 37674 bp |
Gene sequence |
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OMIM ID | | 172400 |
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