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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for GPI (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID2821
Official gene symbolGPI
Full nameglucose-6-phosphate isomerase
Aliases,AMF,GNPI,NLK,PGI,PHI,SA36,
Gene summaryThis gene belongs to the GPI family whose members encode multifunctional phosphoglucose isomerase proteins involved in energy pathways. The protein encoded by this gene is a dimeric enzyme that catalyzes the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate. The protein functions in different capacities inside and outside the cell. In the cytoplasm, the gene product is involved in glycolysis and gluconeogenesis, while outside the cell it functions as a neurotrophic factor for spinal and sensory neurons. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. [provided by RefSeq]
LocationChromosome: 19   Locus: 19q13.1
Gene position34855645 - 34893318  Map Viewer
Gene orientationplus
Gene size37674 bp
Gene sequence
OMIM ID172400