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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CXCR3 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 2833 Official gene symbol CXCR3 Full name chemokine (C-X-C motif) receptor 3 Aliases ,CD182,CD183,CKR-L2,CMKAR3,GPR9,IP10-R,Mig-R,MigR, Gene summary This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed IP10 (interferon-g-inducible 10 kDa protein), Mig (monokine induced by interferon-g) and I-TAC (interferon-inducible T cell a-chemoattractant). IP10, Mig and I-TAC belong to the structural subfamily of CXC chemokines, in which a single amino acid residue separates the first two of four highly conserved Cys residues. Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Inhibition by Bordetella pertussis toxin suggests that heterotrimeric G protein of the Gi-subclass couple to this protein. Signal transduction has not been further analyzed but may include the same enzymes that were identified in the signaling cascade induced by other chemokine receptors. As a consequence of chemokine-induced cellular desensitization (phosphorylation-dependent receptor internalization), cellular responses are typically rapid and short in duration. Cellular responsiveness is restored after dephosphorylation of intracellular receptors and subsequent recycling to the cell surface. This gene is prominently expressed in in vitro cultured effector/memory T cells, and in T cells present in many types of inflamed tissues. In addition, IP10, Mig and I-TAC are commonly produced by local cells in inflammatory lesion, suggesting that this gene and its chemokines participate in the recruitment of inflammatory cells. Therefore, this protein is a target for the development of small molecular weight antagonists, which may be used in the treatment of diverse inflammatory diseases. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] Location Chromosome: X   Locus: Xq13 Gene position 70838367 - 70835766  Map Viewer Gene orientation minus Gene size 2602 bp Gene sequence >CXCR3:complement(9153754..9156355):Length=2602 CCAACCACAAGCACCAAAGCAGAGGGGCAGGCAGCACACCACCCAGCAGCCAGAGCACCA GCCCAGCCATGGTCCTTGAGGTAAGTGCTGCTGCCCAGCCAGGCCAGGCCAGAATTCGAA GTGGAAAACCCGGGGCATCAGGGGAATGCCAGGGCTGGCCCACAGCCCAGGGTCACCACA GGGTTGGGTGAGTAGCTGGAGGCCGCATGGGTTGTGGCAGAAACAGCACTGGGGAATTGG GAACCCAGCTTGGCCACTGACCCTGGGTGCCTCTCCTCTCCTCTCTGGCTTCGGTGTCTC GTCTGCAAAATGGGGGGGGCGGGGGGCAAGTAGACTCGAAGGCTCCCTTCAGGAGACTTG GAACTTTGACTCTTGGCGTGCTGGACTAAATTGGTACTGGGGAGACCTGCAGGTCCATAG TGCTGGGGGTGAGGGGATAAAGAAGATTCCTTCTCAAGCTAAGTGGGGGATCCCCTTGTG GGCAGCTAAATGGCCGTGCAAGCCTCAGTGTAGGGAGGGGGAAGGACTGGGCAGACTGCA TGCATTTGGGGGGCGTGGTGACTTGTAGAGAGGCCACACGGTGGGGGGGGGCGCAGGAAG TTGGGGTCCCCGGACAAGGGCCAAGGAGGGAAGAGGAGGGTTAGTGACTGGAAAAGGGGA TTGTGGAGAGGCGCTGGGGAGGAAGGTGGTTGAACTATGTGTTGGGGGTGGGGCACTGAG GACGCAAGGCAAGCCTGAAGGGAGAGCAGGGAGAGAGAGGACAGTGGGCAGAGAGGGCTC TGGGCACTGGAGGGACGCTCTTCTTCCTGCCCAGGGGTCCCTGGGCCGATGGGATCACGC AGAAGAATGCGAGAGAAGCAGCCTTTGAGAAGGGAAGTCACTATCCCAGAGCCCAGGCTG AGCGGATGGAGTTGAGGAAGTACGGCCCTGGAAGACTGGCGGGGACAGTTATAGGAGGAG CTGCTCAGAGTAAATCACAGACTAAATCAGACTCAATCACAAAAGAGTTCCTGCCAGGCC TTTACACAGCCCCTTCCTCCCCGTTCCCGCCCTCACAGGTGAGTGACCACCAAGTGCTAA ATGACGCCGAGGTTGCCGCCCTCCTGGAGAACTTCAGCTCTTCCTATGACTATGGAGAAA ACGAGAGTGACTCGTGCTGTACCTCCCCGCCCTGCCCACAGGACTTCAGCCTGAACTTCG ACCGGGCCTTCCTGCCAGCCCTCTACAGCCTCCTCTTTCTGCTGGGGCTGCTGGGCAACG GCGCGGTGGCAGCCGTGCTGCTGAGCCGGCGGACAGCCCTGAGCAGCACCGACACCTTCC TGCTCCACCTAGCTGTAGCAGACACGCTGCTGGTGCTGACACTGCCGCTCTGGGCAGTGG ACGCTGCCGTCCAGTGGGTCTTTGGCTCTGGCCTCTGCAAAGTGGCAGGTGCCCTCTTCA ACATCAACTTCTACGCAGGAGCCCTCCTGCTGGCCTGCATCAGCTTTGACCGCTACCTGA ACATAGTTCATGCCACCCAGCTCTACCGCCGGGGGCCCCCGGCCCGCGTGACCCTCACCT GCCTGGCTGTCTGGGGGCTCTGCCTGCTTTTCGCCCTCCCAGACTTCATCTTCCTGTCGG CCCACCACGACGAGCGCCTCAACGCCACCCACTGCCAATACAACTTCCCACAGGTGGGCC GCACGGCTCTGCGGGTGCTGCAGCTGGTGGCTGGCTTTCTGCTGCCCCTGCTGGTCATGG CCTACTGCTATGCCCACATCCTGGCCGTGCTGCTGGTTTCCAGGGGCCAGCGGCGCCTGC GGGCCATGCGGCTGGTGGTGGTGGTCGTGGTGGCCTTTGCCCTCTGCTGGACCCCCTATC ACCTGGTGGTGCTGGTGGACATCCTCATGGACCTGGGCGCTTTGGCCCGCAACTGTGGCC GAGAAAGCAGGGTAGACGTGGCCAAGTCGGTCACCTCAGGCCTGGGCTACATGCACTGCT GCCTCAACCCGCTGCTCTATGCCTTTGTAGGGGTCAAGTTCCGGGAGCGGATGTGGATGC TGCTCTTGCGCCTGGGCTGCCCCAACCAGAGAGGGCTCCAGAGGCAGCCATCGTCTTCCC GCCGGGATTCATCCTGGTCTGAGACCTCAGAGGCCTCCTACTCGGGCTTGTGAGGCCGGA ATCCGGGCTCCCCTTTCGCCCACAGTCTGACTTCCCCGCATTCCAGGCTCCTCCCTCCCT CTGCCGGCTCTGGCTCTCCCCAATATCCTCGCTCCCGGGACTCACTGGCAGCCCCAGCAC CACCAGGTCTCCCGGGAAGCCACCCTCCCAGCTCTGAGGACTGCACCATTGCTGCTCCTT AGCTGCCAAGCCCCATCCTGCCGCCCGAGGTGGCTGCCTGGAGCCCCACTGCCCTTCTCA TTTGGAAACTAAAACTTCATCTTCCCCAAGTGCGGGGAGTACAAGGCATGGCGTAGAGGG TGCTGCCCCATGAAGCCACAGCCCAGGCCTCCAGCTCAGCAGTGACTGTGGCCATGGTCC CCAAGACCTCTATATTTGCTCTTTTATTTTTATGTCTAAAATCCTGCTTAAAACTTTTCA ATAAACAAGATCGTCAGGACCA OMIM ID 300574