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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PTRF (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 284119 Official gene symbol PTRF Full name polymerase I and transcript release factor Aliases ,CAVIN,CGL4,FKSG13,FLJ90031,cavin-1, Gene summary This gene encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of transcription complexes and the reinitiation of polymerase I on nascent rRNA transcripts. This protein also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins. This protein translocates from caveolae to the cytoplasm after insulin stimulation. Caveolae contain truncated forms of this protein and may be the site of phosphorylation-dependent proteolysis. This protein is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy. [provided by RefSeq] Location Chromosome: 17   Locus: 17q21.2 Gene position 40575338 - 40554467  Map Viewer Gene orientation minus Gene size 20872 bp Gene sequence >PTRF:complement(5828619..5849490):Length=20872 AATCAGCGATCAGACTCCGGAGTTTGGCCCGGGAGCTGGGGAGCTCACCGATCCCCCGCC CAGCAGTTCTGGCCGCTGTCCCGGTGCGCACGGACGTGGCTCGAGTTTCCTCTGCTCTCC GCTCTCGCCCGCTAGCTCTCCTCCCTTCCGCTCCTGCTTCTCTCCGGGTCTCCCGCTCCA GCTCCAGCCCCACCCGGCCGGTCCCGCACGGCTCCGGGTAGCCATGGAGGACCCCACGCT CTATATTGTCGAGCGGCCGCTTCCCGGGTACCCCGACGCCGAGGCCCCGGAGCCTTCCTC CGCTGGGGCTCAGGCAGCGGAGGAGCCGTCGGGGGCCGGCTCAGAAGAGCTGATCAAGTC GGACCAGGTGAACGGCGTGCTGGTGCTGAGCCTCCTGGACAAAATCATCGGGGCCGTAGA CCAGATCCAGCTGACTCAAGCACAGCTGGAGGAGCGGCAGGCGGAGATGGAGGGCGCAGT GCAGAGCATCCAGGGCGAGCTGAGCAAGCTGGGCAAGGCGCACGCCACCACGAGCAATAC GGTGAGCAAGCTGCTGGAGAAGGTGCGCAAGGTCAGCGTCAACGTGAAGACCGTGCGCGG CAGCCTGGAGCGCCAGGCGGGGCAGATCAAGAAGCTGGAGGTCAACGAGGCCGAGCTGCT GCGGCGCCGCAACTTTAAAGTCATGATCTACCAGGTGAGCCCACAGGGCGGAAGGCGCCC AGAGCTCCCGCGCCCGGCCCGCGTCCCCTGCCTGGGAGTTGGGGTGGGGAGACCTGCCCG TGGCGCTGCTCCCCTCCCAGCCTGGCCCGGGCGCCCGGCAGATCCACCCTCCTTCCGGTG AGCGCGGCTGGGGTGGGGTTGGGTGGGGTAGGATGGGGTGGAGGGAGCGGCGGACTCCTG GGGCGCGTAGAGGGGCGCGCTCTGCACCTCGCACCTCCCCACTCAGATCCTTCCCTCGGG TCCCAAACTTGTAGCAGAACCGAATTAGCGGGTGGACTCGAGGACGCTGCCCCTCGCAGA CCGCTCCCTCCCTAATTGGCTCTGTCAAACTTCTTCCTACTTGGGGGAAGTTTCTAGGAA AGTCAGGGGTCCCTCGCGATCGTTGGGGTCCGCTGTAAGCGGACACTGGCTGCGGGGCCC GGGCCTGGGGCCTCTGCGCCTGCGGGCCTGATATAGCGGGTGATTCAGGGCTCAGGCACG CACCAGCGGGGGCTGTGCCAAGCGGGGAACGCGACCGCCAACCTCCTCCCCAGACCCTGC GCCCCCGCGCCCCCACATCGGCCTCGGCGGCCCACCCCTGTCCCCTCGCTGCTCTCTGCT CCTGGCCACCAGGCATTTTCAGGCCCTTGAGGACACCCTCACCCGCGGCGCGCTGGCACC CTGGGCCTCCTGGAAGCGGGCGGGGCTGGGCGGGGAAGAGTGGGCGTCAGGAGTGCAAGA GGGGCTGGTGGAGTGGGTGGACAGCCCCTGCGGGGTCCGGCGGTCTGGGCGCAGTCTGGG CGAGGTGAATCACCCCGCATGCCTGCGGGGGCGGGGGCCAGGCGCAGCAGCGCAGCCGGC GGGAGGAGGCTGGCGCCCCCACCCCCCGGCTCCGCCCGGGGCCACTTGTTGCTTTCTTTG CAGCTCTCCCCATTCTTCACACTTGGATAAAAATGTAGCTTTTGGATCATAACCCCCAAT AAACCTGGGAGTCTCGGGTTTCTATGCTGCTCCTCTCCACGCCGCTTCCGCAGTGCCATC GGGGATGAGATTTTGGGCTGGGCGGCAAGTGTTCCAGCCTGGCTCCTCCCCGCCTCCCAA AGGCCTGCTGATGCTCCTAACCCCAGGGAGGCGGGATCGTGTGGGGCAGGGGGGTTAGTC TATGCTCCCCTCTCCCCTTCCTCTCCCTGCTGAAGGGAATGGAAAGAAAGGGAAGGCTGG ATTTCCCACACCCTCCAAGTTAGAAGACCCCTTTCCGGGAGTTGTGGCTCTGCTGACTGC TCTGGGGCCTGGTCGAGCCGGGTTCTGAGTGACCATCTGGGGTGAGGCGAGGGGGTCCTT GGCTTGGTTTCCCCAGGAGGAGTTAAGATAGATGCAAATCAGGACAAGTATCTGGGAAGA GTAGAGACAGAAAGGTGGGTCAGCTGGTACCTATCTGAGGTGGTGGGACAGAGGCAGAAG TGGCACTTGTCCCCCTCCCCACCCTTACCCACGGATGACAGACTCCTCCCAGGAGGCATA TACGTGGCTTTTAAAAGCTTTACTTCCCCTACTTAAGCACTATTTAGATAGAAAATGTTT GCCCAGAGCTATTTCCACTTAGTCTAACTGCTTGGAGGACGCAGGATGAGAGGGGGGCTT TTGACGTTTTTTAAGAGACCTGCTTAGTACTGGGGACATTGAGAGGAGCGGAACAAGACA GGGGTCTGGGACAGCAAGCCAGCTCTATATTTCCTCCAGAGCCTGGTGTGGCCGAGAGCC ACCATGAAGAGCTCGAGGGGTGACCCTTCTCACGCTAACTATCCCAGACCATAGAACCTG GGAAAAGTCTTGGCCTGGAGGTAAACTTCCCTATGCCAAAGATGGAGATTCTGAGAGAAG AGGGAAAGGTATGGAGGGAGAAAGACTTATCTGCAGAGGCCACTGGCATCCCTCTGTTCT GCCCTCTCCAGCAATCTGCAGGGATATGTCTATATTTTAGGGGGTGGGAGGGAATGTGTT CTAATCACAGGTGGCTTCAAATGAATCTGCACTAAACCAAGGCCAGTGGGTGACAGAGAG TTGAGGTAGTAAGAGTAGCTCAAATGGAGTCCCAAACCCACAGAGGGAATAACTAAGAAC TGAAATGGTCCCAACCTGGGGAAGACTTCAGACGTAAGGAAAAGATTCCAGCAAATGGGG TGAGGCTTGGGAAAGCAGAACTTCCCTGAGCTGCAGAGCAGATGTTCCAGGTGGGGACCC GGCTGCTGGAGGAAAGCAGAGGCTGCTCCTGCTCCTCCCAGAGGTCTGCAGGCCTGAGAA GGGAAGGAGGTAAAAATAGCTCTGTGCCTTGGCAGGCCTATTAGGGAAGATTGGGGGCAG CAGCATTTATGGTAAAGTCCGGCTGAAGGGGGAGGATGTTGGGTGGCCAGGCAAAGAGAC AGAGATTTGGAGAAAGTTTCCTGGGATGGTGTGAATTCTCTGGAGGGGCCATAGGGGAAG GGATGCTGTATTCCCCACTACAGGGGTGGGAGGTGATGATGTGGCAGTGGGGGCGGGGCA GAGAACACCAAGGGATGGGAAGGCCCCCGTTGTGGGATGGAGACATCTGGCCTTCCATAC CCTATTCCTGGGGAGAAAAGGAGGGAATCCCTTGTATGGCCCCACCCCAAATTCAGGGAA CTTCTAGACTTAATGATTTCACAGCTTTAAGTTTGCATTTGAACACACACACACACACAC ACACACACACACACACACGAAATTCAGCACCTCCCACCCCAAGGTATCACAGCCCTCATC TTAAACTCACTTCTGAGTCATTACTGCCCTTCTCTGGCATTTCCTTCCCTGTCTCCCAAA CAAAACCTAGCAGTTTGACATTGCATTCTATCAGGCGACACTTGGCTAGCAACAGCTAGT AAATGAGAGAAGTGAATTCTACTAGTTATAGGAGTTAATGGACTGAGGGTTGCAGGACGA TCAGGCCAGATTGTGAATATAGAGGCAGTTGCTCTAAAATACCATGCAGAGGCCGGGCTA GGTGGCTCGTGCCTGTAATCCCAGCACTTTAGGAGGCTGAGGCAGGTGGATCACTTGAGG TCAGTAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCCTCTCTACTAAAATACAAAA ATTAGCCGGGCATGGTGGTGAGCACCTCTAATCCTGGTTACTCGGGAGGCTGAGGCAGAA GAATGGCTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCGAGATCGTGTTATTGCACTCCA GCCTGGGCGACAGAGTGAGACTCCATCTCAAAAATAATAATAATAATAATAATAACAACA ATAAATAAAATAAAATGCCATGCAGATGAGTGGAACTATGATCATTAAAGAACCAATTCT TCCAGGCAACAATTTGTTTTTTGGGGTTTTTTGGTTTTGTTTTTCAGACAAGTTCTCACT CTGTTGCTCAAGCTGGAGTGCAGTGACACAGTCATATCTTACTGCAGTCTCGAACTCTTG GGCTCAAGTGATCCTCCTGGTTCAGCCTCCCGAGTAGCTAGGACTACAGGTGCCCACCAC CGTGCCCGGCAAATTGTTTTTTTTCATATTTGTAGAGTCCGGGGTCTCACTTAGTTGCCC AGGCTGATCTCAAACTCCTGGGTTCAAACAGTTCTCCTGTCTGGGCCTCCCAAAGTGCTG AGACTACAGGCATGAGCTACCACGTGCATCCAGTTTGTTTATTTTTAAACTTAAAAGGCT TTATTTTTAATTACTATGGATACATAATAGTTGTACATATTTTTGGAGTACATGTGATAT TTCGAGACAAGTATGCAATGTATAATGATCAAATCAGGGTAATTAGAGTATCCGTCATAT CAAGCATTTATCATTTCCTTGTGTTAGGAACATCCCAATTCCACTCCTTTAATTATTTTG AAATACGCAATAATTTCTGTTAACTCTATCACCCTATTGTGCTACTGAACGTTAGATCTT ATTCCTTCTATCTAACTGTATTTTTGTACCCATTAACCATCCCTCCAGGCAACAATTTGG AGAGTAGGGCTCTTTTAGATCCAGAAAGTGGGGATAAAATGGAAATACGGGGCTGGGCGC GGTGGCTCACACCTGTAATCCCAACACTTTGGGAGGCTGAGGCGGGCGGATCACCTGAGG TGGGGAGTTCGAGACCAGCCTGACCAACATGGAGAAACCCCGTCTCTACTAAAAATACAA AATTAGCCAGGCGTGGTTGCACATACCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGG AGAATCACTTGAACCCAGGAGGCAGAGGTTGCGGTGAGCCGAGATCGCACCATTGCACTC CAGCCTGGGCAACAAGAGCGAAACTTGGTCTCAAAAAAAAAAAAAAAAAAAGGAAATACA GTCACGCATTGCTTAATGACTGGGATATGTTCAGAGAAATGCAGTGTTAGGCCATTTCCT CACTGTGTGAACATCATAGAGTAACTTTACATAAACCTAAACAGTATAGCCTACTGCACA CCTAGGCTATATGATACAGCCTATTGCTCCTAGGCTACAAACCTATACAGCATGTTAATG TACTGAATACTGTAGGCAACTATAACACAATGGTAAGTATTTGTGTATCTAAATGTGTCT AAACATAGAAAAGGTGCAATAGCCATGGCACGGTAGCTCACACCTGTAATCCCAGCACTT TGGGAGGCCGAGGCAGGTAGATCACTTGAGGTCAGGAGTTAGAGACTAGCCTGGCCAACA TGGTGAAACCCCATCTCTAAATAAAAATACAAAAATTAGGTGGGTGTGGTGGTGGGTGCC TGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGGGAATCGTTTGAACCTGGGAGATGGAG GTTGTGCCTGGACAAGAGAGCAAGACTGTCTCAAAAAAATAGTATAGTATAGTAAATACA TAACCAGTAACACAGTCATGTCTTATCAATATCAAGTATTATGTACTGTATATAATTGTA TGGGCTAGACTTTTATACAACTGGTAGTGCAGCAGGCTTGTTTACACCAGCAATCACCAT AAACACTTGAGTAATTCATTTCACTAACACATTATGATGGCTACAATGTTATTAGGTGAT AGGAATTTTTTATCTCCACTACAATCTTTTTTTTTTTTTTTGGAGACAAGTTCTCGCTCT GTTGCTCAGGCTAGAGTGCAGTGGCACAATCTTGGCTCACTGCAACCCCTCTGCCTCCCA GGTTCAAACAATTGTTCTTCTTCAGCCTTCCGAGTAGCTGGGATTTACAGGTGTGAGCCA CCATGCCTGGCTAATATTTTTGTATTTTTAATAGAGACAGGGTTTCACCATGTTGGCCAG GCTGGTCTCGAACTCCTGGCCTCAAGCAATCCACCTGCCTTGGCCTCCCAAAGTGCTAAG ATTACAGGCATAAGCCACCACAACCAGCCTCCATTACAATCTTATGGGACCACGGTTGTG TATGCCGTCTGTTGACTGAAACGTTGCTATGCGGCTCATGACTAAAAATGTGTTCTGGAG CAGTTTTGAGGAGGCAAAGTCAGTGACCTACATATGGACCAGCAGCAAAGGCCCATCAGA CCTGCTCCAAGTGCCTGGGGATAAGGGCCAGGAAGCATTTAAGGGATTAGGTGTCTCATG GGCATTAAAGGGTAGGGCACCAGGGCTGGAACGAGAGCCTGATGGCTTCTCCTCCCCAAA TCGCAATCCAACCTGTACCTCTTTCCTGGATTCAACGCAAATTAGGGCTACCTTGCTCTA GAAGAACCCCAAACCTTTGTCCAAAAATATTCTCAACCCAGGGCTTTGGTCCCTTTCATC CCTAAAACCCAGCGGCCATGGAGAGTATGCATAGTACATCCCTTCCTCCCAAACTGAGTT TGGGTTGTTTTTCCTGGTCACTGGGTCCAAAGCAGGGAGGGTATTTTTAGGGGTATTCCC AAGACGAAAGGAAATCATGCTATCCCTGGGTTCCTCCCTCCCTTTTTTTTTTTTTTTTTT TTTTTTTGAGAAAGGATCTTAGCTCTGCAGCCCAGGCTGGAGTGGTGGTATCATAGCTCA CTGCAGCCTCAAACTCCTAGGCTCAAGCAATCCTCCCATCTCACCATCTCAGCCTCCCAA GTAGCTGGTACTACAGGCACAAGCCACCATGCCCAGCTAATTTTTAAATTCCTTCCGGCC TTCTTTCCTTCTTCTTTTCTTCTTTTCTCTCTCTCTCTCTCTCTCTTCTTTCTTTGACAG AGTCTTGCTCTGTCACCCAGGCCGGAGTGCAGTAGCGTGATCTCAGCTCACTGTAACCTC CACCTCCTGGATTCAAGCAATTTTCATGCCTCACCGTCCTAAGTAGCTGGGATTACAGGC ATGTGCCACCACACCTGGCTAATTTTTGTATTTTTAGCAGAGACGGGGTTTCACCATGTT GGCTAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCACCTGCCTCAGCCTCCCAAAGT GCTGGAATTACAGGTGGGAGCCACTGTGCTCAGCCTAAATGTTTTTTCTAGAGGGTCCCC ACTGTTGCTTAGGCTGGTCTCGAATTCCTGGGCATAAGTGATACTCCTGCCTTGGCCGCC CAAAGTGCTGGGGTTACAGGCGTGAGCCACGCGGCCTTTTTATTTTTATTTTTCATATTG TAAAGATCAAAGTCAAAAGCATGAGGAGACAGCAAAGAGTGGGCAACTGATAGCAAGAGG GGAGGGGATATTATTGCTAAGCAACTAACCTCAGAAGTAGGAGTGGCTTGGGCCATTTTT TTTTGGAAATATAACATTGTGAATATTTCATCATTCTGTCATTAGCATTTTTTAAATTTT TCTTTTCTTTTTTTCTTTTTTTTTGTTTTTTGTTTTGTTTTGTTTTTCTGAGACAGGGTC TCACTCTGTTGCCCAGGCTGGAATGTAGTGGCAGCTGTCACGGCTCACTGCAGCCCCTGT CGTCCGGGCTCAAGCATTCCTCCTGCCTTAGGCCCCCAAGTAGCTAGGACTACAGACATG CACCACCACATCCAGCTAATTTTTGTATTTTTTGGTGGAGATGGGGTTTCTCCACATTGC CCAGGGTCTCCAATTCCTGAGCTCAAGCAATCCGTCTGCCTCAGCCTCCCAAAGTGCTGG GATTACAGGCGTGAGCCACCGCACCCGGCCTCATTATACACTTCTTGAGCTAGAAGACAC TTTGCAAATAATCAACTTCAACTCCTTCATTTTGTGGTTTAGGAAGCTGAGGCCCAGAGA GGGGAAGTCACTAGCCTATTGTCACTCAAGTGATTGGGAGTCAAACTGGAGCCAGAACCC AGGTGTACCCTTCCGCTACACTCACTGCTCCCCACCCCCTCCTTCCGTTCTGGGCTCTGC AGCAGAAAGCTGAGTGAAGACTAGCCCTGACAAAGCTAGGGCTAGCTGTGGCTCCGACAC TTGCTGAGGGAGTTAGTTGCACAGTCCTGGCCCTGGGGCTGCTTTGCGTGTGTATGGGTG TTTGTGTGTGTGGCGTTGGCTATGAGTGGCCAGCATTGGTGGCCATTGGCTGCTTAGCCT TGTAAGTGCTGAAGTAGAGGCAATGTGTGGTCACCTGGCCTGGTGACAGTGGGAGGGGAG AGGTGTAGGGGAGGGGAGGGGTGTAGGGGAGAAAAGTGGGGGAAAGGAGGGGTGTTGGGG AGGGGAGGGGCGTAGGGGAGGAGTGGAGCTCCTGGTCAGCCGTGGTGTGCCCTGGCAGGG ACTCCACACATACCTAGGAGAGGGACATGTTGTTTCCCTTTCTCTTCAGCCTCTCTGCCA CTCCCACCTCCTCCTTGTACCCTGCAGGGGAGGTTGGGACCTGCTGCTTTGTTTTTTTGA GACTACAGGCTTTATCAAATACTGCTATTGCCTGAGTCCAATAGTGCCGCCAAGTGTCCC TCTCGCCTGGCATCTGATTGCTCAAAGCAAGAAGCCTATAGTCTTCCACAACTCAGCCCC TCAGGAGAGAGAGTTGGGGGCTGCCGCAGAGGTCCAGAGGTCCCAGGACATAGGCTCACC TGTCATAAAAATAGCTTGGTTTTGCCAGGCACAGTGATGTGTGCCTGTAGTCCCAGCTAC TCAATAAGTTGAGGCAGGAAGATTGCTTGAGACTAGGAGTTTGAAGCCAGGTTGGACAGC ATAGAGAGACTCTATCTTAAAAAAAAAAATAGAGCTTGGTTTTGGATCCTGATTTCTCTG TGCATTTTAGTGTATGATATCTTAAGTGGTAGCAAGAGGGAGGGGTGGCAAGGGAGACAG AAGGTGGGGACGTGGCCAAAGGGAAATTGCCAGGATGTCCCTCTTCCATGCCTATCCCTC TCCTCATTTGGGGTAGCATCCTGTGTCCACCCTACCCCAGGGAAGAATGAAAACAGATTA ATCTGGGCACACTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGTGGA CCACTTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGCGAAACTCCGTCTCTACC AAAAATACAAAAAAAATTAGCCGGGCATGGTGGCACACACCTGTAATCCCAGCTACTAGG GAGGCTGAGGCAGGAGAATCACTTGAACTCAGGAGGCAGAGGTTGCAGTGAGCCAAGATC ACGCCACTATACTCCACAGCCTGGGTGACAGAGCAAGACTCCGTCTAAAAAAAAACAACA ACCACAAAACTGGGATTGGCAGAGTCTGACTCTGAAGACAGTGAAGTTGTGTGCCTTTGT ATTTACTCATCTGAGCCTCCCCAGTTATAATCCAACAACTAGCCCCTTAGAAAACTCCTT ATCCACCCCTAGTAGCCTCCATAGTCTTCCTATGATTATGGCTGGGGAAGGATTGGAGAT GGAAGCCCAAGAATGGGACTGGGGAATATTGTAGAGGGAGGAAGGGAGGGGCTCAATTGA AGCTGTGTTTATTAATTCTTGGGCTTGAGTTTGCCCCACCCCTTTTGGCCCCAGGGACCT CTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTCCCTTTTTGAGACAGACTTTTGCTCT GTCGCCCAGGCTAAAGTGAAGTGGCTGGACCTCAGCTCACTGCAAACTTCACCTCCCTGG TTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGAAATTTCAGGCATGTGCCAACA GGCCCCACTAACAGTATTTTTTGCAGAGACCTGGGCAATGTTGCTGAGGCTGGTCTTGAA CTCCTGGGCTCAAGGGATCCACCCACCTTGGCCTCCAAAGTGCTGGGATTACAGGGATTA TAGGCGTGAGCCACTGTGCCCAGCTCCCAGGGCCCTCTTGATGAAGCATTTAAAATGAGT TTCTAGGCCAGGCATGATGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGCCCAAGG AGGGCAGATCACTTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCTA TCTCTGCTAAAATTTCAAAATATTAGCTGAGCATGGTGGCACCCACCTGTAATCCCAGCT ACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCGGAGGTTGCGGTGAACC AAGATCAGAGATCACGCCACTGCACTACAGTTTAGCAGCCTGGGCGATAGAGAGAGGCTC CATCTCAAAAAAATAAATAAAATAGTCCAGGCGCAGTGGTTCCCGCCTGTAATCCCAGCA CTTTGGGAGACCGAGACAAGAGGATCGCTTGAGGCCAGGAGTTCAAGACCAGCCTGGCCA ACACAGTGAAACCCGGTCTCTACTAAAAGTATAAAATTAGCTGGGCGTGGTAGCATGCAC CTGTAATCCCAGCTATTCGGGAGGCTGAGGCAGGAGAATTACTTGAACCTGGGAGGTGGA GGTTGCAGTGAGCCAAGATCGTGCCACTGCACTCCAGCCTGGGCAACAGAGTGAGACTCT GTCTCAAAAAAATAAAATAAAATAGTTTCTAGCCTGGGCAACATAGTGAGACCTTGTCTC TATCAAAAAAAAAAAAAAAATTAGCCGGGTTTGATGGTACACAACTGTAGTCCTAGATAT TTGGGAGGCTGAGGTAAGAAGATTGCTTGAGCCCAGGAGTTGGAGGCTGCAGTGAGCTAT GATTGTGCACTGCACTACAGCCTGGGCAACAGAGCAAGACCCCCATTTCTAAAAAAAAAA AAAAAAAAAAAGTGGTTTATTTCCATCCTAATACATTGTGCTCCCCTCCCTACTCACCAG CCCCTACTCTGCATGCCACCAAGGCCCTTTTTTCTCAACTCCTTTTGCACCCACCCCAAG CCCCATTTAAACCCCTTTTCCTCATCTTAGCCCAAGAAGAAGCCGAATGCACCCTCTGAC CTGGCCACACCCAAGATCGTGCCTTTTGACCTGCCTGAGACTGAGCCCTTTGACCTGAAG CCTGAGACAGTGCCTGAGCTCCCACCTTTTGACCAGACGCCTAGGGCACTGCCATATTAC CCAGAGCCTGGGCCCCGGCCCACCCCAGAGGAGCTGACAGCCGGTGGGAGTGTTTAGGGT CTCCCGGATCCCGTTCTGTGGGCGTGGGGTATCTCTTCAGTCCACTGTCAGCCCACAGCC TAGTGGTGATCACTGCCAGGAGGGCCACCATCCCCAGTCACTGCCCACTGTGGACGGGTG CCGGGTACTGTGAGAACACTGGCGTTATGCAAAGTTCAGGAGAATGGGATGTATACAGTG GGGATGGGAGGGGAATGGAAGGGGCCTCCCCACTTCTTGGTTTCTGTTTTTAGTAGTAAA TGCTCCCCCACACTTAAGCTGCACCCGAAGGCTGCCTAGCATGAAGGCGCATGGCTTCTG GTTCTGCCGTTCCCCCTGCTGCCTCCTCCTGAGGGACAACCCAGTTTGGCTCAAAGCCTC TTTGGAGAGGGCCATCATGAGGCTCAGGCCTGGGGTCTGTTCTGTGCCCTCTCCACCCAC TCCCTGCAGCTGAGGAAAACATTTACACGTATTTTCTCCAGTTTCTTTTAGAAAATGCTT TGCAAAGAGATCGCTTATGTTTGCCAGATCCTGCCTTGGGTGGGGTGCCCAAAAGCTGCC AACTCACAGATGCCAGGAGGGGGACATTCTAGCTGGCTCTGGCTCAGGACCTCTGGCCTT CCTATAGCAGAGTGTTTCTCAACTTAAAAAAAATGTTAAAAAAATTTTTTTTAGAGATGG GGTTGGACTGTGTTGCCCAGGCTGGTTCTGAACTCCTGGGGCTCAAGTGATCCTCCCACC TCAGCTTCCCAAAGTGCTGGGATTACAGATGTGAGCCACCTCACCCAGCCAGTTTTTGTT GTTGATGGTTGTTGTTGTTTTCATAATCACTCCCATATACAGACCTTTTAGTTTTTTTTT TTTTTTTTGAGACATAGTCCTACTCTGTCACCCAGGTTGGAGTGCAGTGGAGTGATCTCG GCTAACTACAACCTCCACCTCCTCGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTA GCTGGGATTACAGGCATGTGCCACCACACCCAGCTAGTTTTTGTATTTTTTGGTAGAGAC GGGGTTTCGAACTCCTGACCTCAGGTGATCTGCCCCGCCTCCCAAAATTCTGGGATTACA GGCATGAGCCACCACCCCTGGCCCTTTCAATTTTTTTTTTTTTTTTTTTTTTTTTTTTTT TTTTTTTTGAGACAGAGTCTCACTCCGTCGCCAGGCTGGATTACAGTGGCACGATCTCGG CTCACTGCAATCTCCACCTCCCTGGTTCAGCCTCCCGAGTAGCTGGGATTACAGGCTCGT GCCACCACACCCAGCTAATTTTTGTATTTTTAGTAGAGACGGAGTTTCACCATGTTGGCC AGAATGGTCTCGATCTCCTGACCTCGTAATCTGCCCACCTCGGCCTCCCAAAGTGCTGGG ATTACAGCCTTGAGCCACAGCACCCGGCCCCTTTCAGATATTTTTAACCAAGCTGTTCAT CTCCCTCACGAAATGTTAAAACAATAGATAAACTGTATATCTGTTTATGTACTGTGGCTC TTGGGAGTGGCACAAATCATTGTGATATCTAAGTCCCCTCCCAATCTCCAAGAATCAGTT TTCACCCTTTTGGATGCAATTTCACCCCTGCCAAGAATGCACGCTAGAGCAGAAGGGAGG GACACTTCTGCCCTTGGGGTCTCTCATCTCCTTGTCTTAGCAACCTCTAGCAGAGGTCCT GAATTTTAAAGACGTTCTCTCCCCTTCACCTCTCCCCTCCTCTGCACCCTCTTCTAACAT ACACTCTAAGCAGATCCTGGGTCTCTGAATTACCTCTCCAGTCTCCTCCAGCCATTCCCA GGCAGTGGTTGGGGACCTAGAGCTGGTCAGCCTTAAGTCAAGAGAGCCTCCTACCCAGAC CCATGTGGCATCTGTCCCTTCTCCCTAACAAATGTGAAGTGCCTGGCCAAGGGCCAGATG TGTAATAGGTGCTCAATGACATTATAATCTTATAAAAATCTTCCTAAGCCAGATCTCGAG TTTAGACAGCAGGGTTGGGGGGTGGAGTGGAAGAGGCTGGGAGCCTCCCTGTGGCTCCTC TGCATCCATCGAGGATTGAGGAGCTATGTGTGCTTGGCAAAGGGCAGGGGGAACTGTAAT GCTTTTGTTCAGAGCTGGTCATTAAAGGTAACTCTGGAAACCAAGCCTATTGGGAGTGGT GGTTTTGTTTAATAAAAACGAGAAACAGAACAAGCAGAGCCGTCCCTCCTTGCCATCCCC TGAGGTCCTTCCTTTGGCTTAGGAGCTCTGCCAGAGAAGTAGGGGTGGGACAAGGGTGCC TGGCCTGTGTGCCCAGGGTGGAGGGAGATGATTTTGGATTGTGTTTGTGGTGGTTGTACC AGCAAGCAGATGGGTGGGACCAAGACAGCACTCCAAGGCTGTGAGTCATGGGGGAAACCT GGCCTGGAGTGGAGAGGAAAAGCTAATGGTGAAATACCCTCTCCAGAGCCAGCCTATTGG ACATCATCCCAGGATTCAGCTCAAGTTGTTTCGTCTCCTGTCCCCTGACCTTCCACCAAG AAGGCAGCTCCTATGGTGTAAGCCGTCACTCCAGGGGAAGCCTACGATGAATGGGGTTAG AGCCCCCAGATCCCTTACTGGTCTGGAGAGATTTCTAAATCCAGGAATAAACCTCCCCTT GGCCAGGCACAGTGGCTCATGCGAGAAATCTCAGCACTTTGGGAGGCCGAGGCAAGGGGA TCACTTGAGCCCAGGAGTTTGAGACCAGCCTGGGCAACATAGTGAGACTCTGCCTGTACA AAAACTACAAAAATTAGCTGGGCATGGTGGCGTGCGCCTGTAGTTCCAGCTACTTGGGAG GCTGAGGTGGGAGGATCACTAGAGCCCAGGAGGTTGAGGCTGTAGTGACCTGTAATCATG CCACTGCACTTCAGCCTGGTTGACAGAACAAGACCCCATCTCAAAACAAACAAACAAAAA CACAAAAATGGCCAGATGCGGTGGCTCGTGCCTGTAATCCCAGCACTTTGGGAGGCCGAG GTGGGAGGATCCCTTGAGGTCAGGAGTTTGAGAACAGCCTGGCCAACATGGTGAAACCCT GTCTCTACCAAAAAATACAAAAACTAGCCAGGTGTGGTGGTGCATGCCTGTAATCCCAGC TACTTGGGAGGCTGAGGCAGGAGAACTGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGC CGAGATCGCGCCACTGCACTCCAACCTAGGTGACAGAGTGAGACCATGTCTCAAAAAAAA AAAAAAAAAAGGCCGGGCACGGTGGCTTAGGCTTGTAATCCCAGCACTTTGGGAGGCTGA GGAGGGCGAATCACATGAGGTTGGGAGTTCAAGACCAGCCTGATCAACATGGAGAAACCC CGTCTCTACTAAAAATACAAAATTAGCCAGGTGTGGTGGCACATGCCTGTAATCTCAGCT ATTTGGGAGGCCCAGGCAGGAGAATTGCTTGAACCTAGGAGGCGGATGTTGCGGTGAGCC GAGATCGTGTCATTGCACTCCAGCCTGGGGAGCAAGAGCAAAACTCCATCTCAAAAAAAA CAAAAAAACTAAAAAACAAAAACCTCCTCTCACTAGGATTGCTTCCTTATGTTGTAGTTT GAGACCTTTCATGAGGCACTAGGAAGATGGCATTGGCTATAAGAAGTCTGCAGCTCTCTC CCCAGTCCCATTCACTTCCAAGTTCAGCTGGCAAAGACCTTTATCTAGGAAGCCACAGGC CAGGAAAACCAGCCAGCTCAGCCTTTAGGGGTGGGGTGGAGCAGGCAGCAGGGGTAGGGG AGAAGCGGGGGATGCTGGGGGTAGGGCAGAGAGACAAAGTGGATTTGTTTTCCAGCAGCT GGGGCTGTTTCCTGACTATTCCCTGCCTGTCACCCTTAATCCCTCCCTAGCCTATTCACA TTGTCTGAGTTTAGTGAAAGGAGGGGCTCTCTCCACCCTTTGGTGGGGCGTGGGTGGGTT TTTAAGTCTGGGAGGTTATGAAGGAAAGATCAGAGCTGAATTTTTTTTAATATATATATA TACTGGGGCTGCAGGTAAATTCTGGGTGGAGATGGATGAAGAGGGTTTAGATCCTACAAT GATGTATAAGTCTTAAATGATATGCACTCCAGTAGCAGGCAGGGTAAGGGTGATTGTAGG AGCCCCAAAGTGAATGACTGGAAATCAGAGGGAATGCAAAGAGAAGTTGAGACTCTCCTA CACTCAGAACAAGGAAAACACCCTTCAATGCCTCAGTGAATGATAAGAGGCAGAGGGATA AACAAAATGCCCTAGGATTGCCCATGATCTGCACTAAGCCGTCTATGGCAGGTAGAGACT ACAAGTCCCAGCATGCCCTGTGCCCAGGTCACCTTGCCTGCTGGGAGGTGTAGTTGGGTA ACAGAGAGCTGGAGGTGGCTTGGTGCCCAGCAGAGCTGATGCCCAGATGAGAGAAGAGGT GGAGCCAGCATTCCCTCTTTGTCCCTGCTAATGCTATTGACAAGAAGGGAAGGAAGTTGG GAGAGGGTGTTCCTAGTTTTCAGTGTAAACCAGGAAACTCTGGGGGGATGTTGATGGGAG GGAAGAGGAAAGAGGTTGGGGGCTGGGGAAGGAATTTCTGTAGCAGGTGGTGCAGAGATA CCGAGCAGCCTATGTATAGGGGTGTGTGTGTGTGGTGTCAGTGAGAGGACTCAGTTTATG TTGCCTTAATTTCTTAGGGGACAGGATTTTTCTTATAATTCTGGGAAATGGTCTTCAGAA AACCCTTTAGAAAAGCGACTATCTCTCGTTCCTTCATTTGAAGTCACTAAAGGGAGTCTG GGCCAAAGAGATCCTATTGATGATCTTGGTCTGCCCTTTCCCTTTCTGTGCTCAGCCTCC CCTGCTCTCTGATGAGGGTGGAGGTGGGGGAGGGAGTGATCCAGAGATTCTGAAATGTTG GCCAGAGTCAAGATCTTGGAAAATCTTCCCGGAATGGAAAGCAGTTCTGGTGCTAAGTCC TCCAAGGAGAAGACAGAAAAGCAAAGAACTGGTTCTGAGCTCCAGGGTCATGGGGAATCT GAGACCACCCATCCTACTCCTAGACCCCTGAGCTCAGGCTTTGTGCTGGGGGCAGGGGGT AGGGAAAGCAAGAATTGAAAAGTAATCTCTCTTCTATCCCAAAGTAGGGAAGTCACAACC AGAAGAAATGTCCAGACTGGGGAGAAAACATGTCCGTGGCTCCCAGCCAGCTTCTTCCTC TTTCCAATATCAATTTCTAAATGTGGGGGAGGGGGAGAATGACCACTGGTGGAGCCAAAC AGTATGAAGGAGTCAAAGAAGGTGGAGGTGGGGGAGGGTGGACCACAGTTCTCCATCTCT AAGGCTGGTTCTGAAATAGCTTGAGGCCAGGAGCAGTGGCTTATGCCTGTAATCCCAGCA CTTTGGGAGGCCAAGGCGGGTGGATCATTTGAGGTCAGGGGTTCGAGACCAATCTGACCA ACATGGTGAAACCCCGAGTCTACTAAAAATACAAAAAAATTAGCCAGGTGTGGTGGCGCA TGCCTGCAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGGC AGAGGTTGCAGTCAGCAGAGATCGTGTCACTGCACTGCAGCCTGGGCGACAAAGCGAGAC TCCATCTCAAAAAAAAAAAAAAAAAGAAATAGCTTGAGTCTAGGAAATGCACTTCCTTTA CTTTACCTGCTTGGGTGGGTAGGTGCAGCTGTGGGCTCAAACCCCTACCCGCTTTCAACT TAGACACTCCCACCACTTGCTTTTCGGCCTGGCTCGGGCAGTGTGCGATTTGCGGCACCA GAGGGCGCTCCGCCCATTTCCAAAGTGGAGCTGTGTCTCCCGAGGGCCGTAGTGGTTTAA TATCATCTACGGGTGGAAAGGGATCAGGACAGGGTTGGACGACCACAGAGATTTTAGCCC AAGTGCAATTATTACGCAACCCCATCTCCGACCCGAAGTTTGGTCCCCTGCTCCCGCGGT CTGTTTAGTCACCATTCGTTCAACACACATGTTTTTTAGAGAATGGCGGCGCGAGGCCGG GCGCAGTGGCTCACGCCTGTAATCCCAGAACTTTGGGAGGCCGAGGCGGGCGGATCACCT GAGGTCGGGAGTTCGAGACCAGCCTGACCAATATGGAGAAACACCGTCTCTATTAAAGAT ACAAAATTTAGCCGGCGTGGTGGCGGGCGCCTGTAATCCCAGCTATTCGGGAGGCTGAGG CAGGAGAATTGCTTGAACCCGGGTGGCGGAGGTTGCGGTGAGCCAAGATCGCGCCCACTG CACTCCAGCCTCGGCAACAGATCGAGACTCCGTTTAAAAAAAAAAAAAAAAAAAAAAACA AGGAGAGAGAGAGAGAAAGAATGGCGACGCGGGGTTGGGGGGCCGGAGATGGGTGATATG TTGCCCAGGCTGGTCTCGAACTCCTGGACTCAAGCCATCCTCCTGCCTCGGTCTCCCACA GCGCTAATATTACAGGCGTGAGCCTACACACATTTATTGAGCGCCCGCCAGTTTCCTGGG GACCACGAGCGTCCCATGCTCCCCTCTCTCCAGGATCGTCACCACCCTGACTCAGGCTCG CCCACATCCGCCTCCTCCGACGCCTCTCATGTCCCTTCTCCTCTTCCCTTAGGATGAAGT GAAGCTGCCGGCCAAACTGAGCATCAGCAAATCGCTGAAAGAGTCGGAGGCGCTGCCAGA GAAGGAGGGCGAGGAGCTGGGCGAGGGCGAGCGGCCCGAGGAGGACGCAGCGGCGCTGGA GCTTTCGTCGGACGAGGCGGTGGAGGTTGAGGAGGTTATTGAGGAGTCCCGCGCAGAGCG TATCAAGCGCAGCGGCCTGCGGCGCGTGGACGACTTCAAGAAGGCCTTCTCCAAGGAGAA GATGGAGAAGACCAAGGTGCGTACCCGCGAGAACCTGGAGAAGACGCGCCTCAAGACCAA GGAAAACCTGGAGAAGACGCGGCACACCCTGGAGAAGCGCATGAACAAGCTGGGCACGCG CCTGGTGCCCGCCGAGCGGCGCGAGAAACTGAAGACGTCGCGGGACAAGTTGCGCAAATC CTTCACGCCCGACCACGTGGTGTACGCGCGCTCCAAGACCGCGGTCTACAAGGTGCCACC CTTCACCTTCCACGTCAAGAAGATCCGCGAGGGCCAGGTGGAAGTGCTCAAGGCCACCGA GATGGTGGAGGTGGGCGCCGACGACGACGAGGGCGGCGCGGAGCGCGGGGAGGCCGGCGA CCTGCGGCGCGGGAGCAGCCCCGACGTGCACGCGCTGCTGGAGATCACCGAGGAGTCGGA CGCCGTGCTGGTGGACAAGAGCGACAGCGACTGAGCCGCCCCCGCTGCCACCCACCCCAT TCCTCGCTCCTTCCGAACTTCCTCTTTCGCATTCTCTCTCGGCTCGAGCTGGCTGAGATT TTTCTAAATTGAAAACACGCCCCCCTCCCCACACCTCCAGGAACTCCACTCCCAGTCTTA GAGCTGTTAGGACCCGATGGGGAGGCAGCCCCCGCAGTGGACAACCCCCGCTTGGACACA GTCCGAGTGGAATGGGAAGGGAATGGTCAATCCCTGTCCTGGTTGTCCAAGTCGGGATCT CAGAGGAAATTGCAGTGATTCCACGGTTAGGCCCCCCTGGGGGGGCTGCCTTCCCCTCAG CCTCTCCCCACACCACCCACCCAGCTGCTGTCATTCCGCTCACTGAGCTCTTCTTCATTC TCACCCTGATCCCTGGGGGACTCAAAGCCAAAACTGCCCAAAGAGGAAAGATTGAATCCT AAAGGGGATCCCTGCCCCCATGGGAGGCCCCCTACTAGAAGGACGTGAAAGCAGCTTTTG GGGGAAACTGAGGCAGTGGGGAAGACAGAGCAGAATGAGCCCTCACCCTGGCTGGGGGTC CAGCACAGGCTGTATCTGCAGAGGGTCCCAGAGGAACGCTGGAGCCAAGAGAAGCCCTGG GAAGGAGGGGTGGGGAACGACATGCATGTGAGGGATGGCACACTGATGTGTTTATGCACC TGTACACAGGAGCGCATGGCCATGGCTTTGGAAAGGAGAATGGAAAAATAGAAGAAGGTC GGCCGGGCTTGGTGGCTTATGCCTGTAACCCCAGCACTTTGGGAGGCCGAGGTGGGCGGA TCACCTGAAGTCAGGAGTTCGGGACCAGCCTGGCAAACACCCCATCTCTACTAAGCGAAA ACCCATCTCTACTAAAATTACAAAAATTAGCTGGGCATGGTTGCGCATGCCTGTAATCCC AGCTACTTTGGAGGCTGAGGTGGGGAGAATTGCTTGAACCTGGGAGGTGGAGGTTGCAGT GAGCCAAGGTCGCGACACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCATCTCAACA GAAGGAAAAAAAAGGAAAATAGGAGAAGGTGGAAATGGGTGAAGAGAGAAGTCCCCTCAC TAGCTGCATGAGAAATCTATCTTACTGTGGTTCTCCATGGGCAGCAGGACCATTTTTCAG AATCAAGAGGGAGGACAGTGTGAGAAGGCGATGATCCAAAGAAGACAGAGAGGTCAGCCC CACCCGATCCCTCAAATGGGCTCTTGGAGGCACCCCCAGGGGCAGCCCATTTCTCAAAGT CCAGAAAATTAGGGTCCCAGAAGGGGGCAGCAGCAGGCTGGGAGTTAGGAGGGAGAGCAG GGTGCCGGCCCTGCCACCAAGTTGAGAGCTGGAGGGGAGGTGGGGAGAGAACATCACAGA GCAGCCAGCCCTGGTTCACTCCTGGCAGTTTCTTCTCAAGCTCCTTCCCTAGGAGCATGG TGGCACGTGCCTGTGGTCTCAGCTACTTGGGAGGCTGAGGCGGGAGGATCGCCAGAGCCC AGGAGTTTGAGGCTGCAGTGAGCTATGAGGGTGCCTCTGTGCTCCATCCTAGGCAACAGA GTGATACGCTGTTTAAAAAGGAAAAAATCCTTCCCTAGAGCTAGTATCCTAAAGCTGCAG AGCTAGCCCAGACCTCATTGGTTTCCTTGTCCTTGGGGTGCTTTTCCTGAATCTTTGCGG GTGAAGGGAGTGTTGCTCCCAGTCCAGAGGCCTGATTCTGTTTGGACTGGGTTCTCAAGA CACGACCAGGTTCTCAAGACACGAGTCCCCTTGTTCCTCCCCATTAAAGGGGGTTTGTCA GAAGCAAGAACAGCCCCTCTCCCCAGTCACAGCCTGAAGGGAGGCCCCGAGAGCTTCCTC CTTCCCCCCACCTGCTCCTTACCTTCTCTGCCCTGCTTTTTAGAACTGCAGTTCATTGTT TTAAGGGATTGGGGGAGGGAGCCTGGGGACACAAACCTTTTATACAATACAAAGCTTTGC TTTTTTTTTTTTTTTCTTCCTTTTCCCTTTCTCGGTTCTCTTCTCTCCTCTGAATGGCTG AAGACCCCTCTGCCGAGGGAGGTTGGGGATTGTGGGACAAGGTCCCTTGGTGCTGATGGC CTGAAGGGGCCTGAGCTGTGGGCAGATGCAGTTTTCTGTGGGCTTGGGGAACCTCTCACG TTGCTGTGTCCTGGTGAGCAGCCCGACCAATAAACCTGCTTTTCTAAAAGGA OMIM ID 603198