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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for ANK2 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID287
Official gene symbolANK2
Full nameankyrin 2, neuronal
Aliases,DKFZp686M09125,DKFZp686P0948,FLJ38277,LQT4,
Gene summaryThis gene encodes a member of the ankyrin family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton. Ankyrins play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. The protein encoded by this gene is required for targeting and stability of Na/Ca exchanger 1 in cardiomyocytes. Mutations in this gene cause long QT syndrome 4. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq]
LocationChromosome: 4   Locus: 4q25-q27
Gene position113739239 - 114304896  Map Viewer
Gene orientationplus
Gene size565658 bp
Gene sequence
OMIM ID106410