Entrez gene ID | | 2874 |
Official gene symbol | | GPS2 |
Full name | | G protein pathway suppressor 2 |
Aliases | | ,AMF-1,MGC104294,MGC119287,MGC119288,MGC119289, |
Gene summary | | This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq] |
Location | | Chromosome: 17 Locus: 17p13 |
Gene position | | 7218658 - 7215978 Map Viewer |
Gene orientation | | minus |
Gene size | | 2681 bp |
Gene sequence |
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OMIM ID | | 601935 |