Database of mammalian genes
Home

Home Search Browse Statistics User guide FAQs Links Questions Contribute Download


Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for TRIB2 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID28951
Official gene symbolTRIB2
Full nametribbles homolog 2 (Drosophila)
Aliases,C5FW,FLJ57420,GS3955,TRB2,
Gene summaryThis gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]
LocationChromosome: 2   Locus: 2p24.3
Gene position12856998 - 12882860  Map Viewer
Gene orientationplus
Gene size25863 bp
Gene sequence
OMIM ID609462