Entrez gene ID | | 2925 |
Official gene symbol | | GRPR |
Full name | | gastrin-releasing peptide receptor |
Aliases | | ,-, |
Gene summary | | Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene. [provided by RefSeq] |
Location | | Chromosome: X Locus: Xp22.2-p22.13 |
Gene position | | 16141424 - 16171641 Map Viewer |
Gene orientation | | plus |
Gene size | | 30218 bp |
Gene sequence |
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