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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for GSTA3 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID2940
Official gene symbolGSTA3
Full nameglutathione S-transferase alpha 3
Aliases,GSTA3-3,GTA3,MGC22232,
Gene summaryCytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class genes that are located in a cluster mapped to chromosome 6. Genes of the alpha class are highly related and encode enzymes with glutathione peroxidase activity. However, during evolution, this alpha class gene diverged accumulating mutations in the active site that resulted in differences in substrate specificity and catalytic activity. The enzyme encoded by this gene catalyzes the double bond isomerization of precursors for progesterone and testosterone during the biosynthesis of steroid hormones. An additional transcript variant has been identified, but its full length sequence has not been determined. [provided by RefSeq]
LocationChromosome: 6   Locus: 6p12.1
Gene position52774496 - 52761437  Map Viewer
Gene orientationminus
Gene size13060 bp
Gene sequence
OMIM ID605449