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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for GSTA4 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID2941
Official gene symbolGSTA4
Full nameglutathione S-transferase alpha 4
Aliases,DKFZp686D21185,GSTA4-4,GTA4,
Gene summaryCytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, which are located in a cluster on chromosome 6, are highly related and encode enzymes with glutathione peroxidase activity that function in the detoxification of lipid peroxidation products. Reactive electrophiles produced by oxidative metabolism have been linked to a number of degenerative diseases including Parkinson's disease, Alzheimer's disease, cataract formation, and atherosclerosis. [provided by RefSeq]
LocationChromosome: 6   Locus: 6p12.1
Gene position52860178 - 52842746  Map Viewer
Gene orientationminus
Gene size17433 bp
Gene sequence
OMIM ID605450