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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for GTF2H2 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID2966
Official gene symbolGTF2H2
Full namegeneral transcription factor IIH, polypeptide 2, 44kDa
Aliases,BTF2,BTF2P44,MGC102806,T-BTF2P44,TFIIH,
Gene summaryThis gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This gene is within the telomeric copy of the duplication. Deletion of this gene sometimes accompanies deletion of the neighboring SMN1 gene in spinal muscular atrophy (SMA) patients but it is unclear if deletion of this gene contributes to the SMA phenotype. This gene encodes the 44 kDa subunit of RNA polymerase II transcription initiation factor IIH which is involved in basal transcription and nucleotide excision repair. Transcript variants for this gene have been described, but their full length nature has not been determined. A second copy of this gene within the centromeric copy of the duplication has been described in the literature. It is reported to be different by either two or four base pairs; however, no sequence data is currently available for the centromeric copy of the gene. [provided by RefSeq]
LocationChromosome: 5   Locus: 5q12.2-q13.3
Gene position70363497 - 70330951  Map Viewer
Gene orientationminus
Gene size32547 bp
Gene sequence
OMIM ID601748