Entrez gene ID | | 29882 |
Official gene symbol | | ANAPC2 |
Full name | | anaphase promoting complex subunit 2 |
Aliases | | ,APC2,RP11-350O14.5, |
Gene summary | | A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation. [provided by RefSeq] |
Location | | Chromosome: 9 Locus: 9q34.3 |
Gene position | | 140083057 - 140069236 Map Viewer |
Gene orientation | | minus |
Gene size | | 13822 bp |
Gene sequence |
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OMIM ID | | 606946 |
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