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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PADI1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID29943
Official gene symbolPADI1
Full namepeptidyl arginine deiminase, type I
Aliases,HPAD10,PAD1,PDI,PDI1,
Gene summaryThis gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type I enzyme is involved in the late stages of epidermal differentiation, where it deiminates filaggrin and keratin K1, which maintains hydration of the stratum corneum, and hence the cutaneous barrier function. This enzyme may also play a role in hair follicle formation. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq]
LocationChromosome: 1   Locus: 1p36.13
Gene position17531621 - 17572501  Map Viewer
Gene orientationplus
Gene size40881 bp
Gene sequence
OMIM ID607934