| Entrez gene ID | | 29990 |
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| Official gene symbol | | PILRB |
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| Full name | | paired immunoglobin-like type 2 receptor beta |
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| Aliases | | ,FDFACT1,FDFACT2, |
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| Gene summary | | Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the non-ITIM-bearing member of the receptor pair, which has a truncated cytoplasmic tail relative to its ITIM-bearing partner, and functions in the activating role. Alternatively spliced transcript variants have been noted for this gene, but the full-length nature of many is not known. [provided by RefSeq] |
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| Location | | Chromosome: 7 Locus: 7q22.1 |
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| Gene position | | 99955626 - 99965452 Map Viewer |
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| Gene orientation | | plus |
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| Gene size | | 9827 bp |
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| Gene sequence |
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| OMIM ID | | 605342 |
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