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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for HGF (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID3082
Official gene symbolHGF
Full namehepatocyte growth factor (hepapoietin A; scatter factor)
Aliases,DFNB39,F-TCF,HGFB,HPTA,SF,
Gene summaryHepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. [provided by RefSeq]
LocationChromosome: 7   Locus: 7q21.1
Gene position81399452 - 81331444  Map Viewer
Gene orientationminus
Gene size68009 bp
Gene sequence
OMIM ID608265