Entrez gene ID | | 3093 |
Official gene symbol | | UBE2K |
Full name | | ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast) |
Aliases | | ,DKFZp564C1216,DKFZp686J24237,E2-25K,HIP2,HYPG,LIG, |
Gene summary | | The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq] |
Location | | Chromosome: 4 Locus: 4p14 |
Gene position | | 39699664 - 39784412 Map Viewer |
Gene orientation | | plus |
Gene size | | 84749 bp |
Gene sequence |
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OMIM ID | | 602846 |
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