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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for HLA-DPA1 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 3113 Official gene symbol HLA-DPA1 Full name major histocompatibility complex, class II, DP alpha 1 Aliases ,HLA-DP1A,HLADP,HLASB,PLT1, Gene summary HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq] Location Chromosome: 6   Locus: 6p21.3 Gene position 33041378 - 33032794  Map Viewer Gene orientation minus Gene size 8585 bp Gene sequence >HLA-DPA1:complement(4476974..4485558):Length=8585 GCTCACAGTCATCAATTATAGACCCCACAACATGCGCCCTGAAGACAGAATGTTCCATAT CAGAGCTGTGATCTTGAGAGCCCTCTCCTTGGCTTTCCTGCTGAGTCTCCGAGGAGCTGG GGCCATCAAGGGTGAGTGCTCAGGAGGACGCAGGAGCGTCGGGGTGAGTGATGGGGTGGT TCACATCAATTGCTGCTTCAGGGATCACAGATTTTAGGGGCTCATTGATCTATCTGGTCC TCATAGTCTATGTTCCCTCTGGCCCTCATAATAATAACAGCAATAACAGCCAGAATTTAT GAGACTCCTGCATATTTTCTTTCCCCATTTACATCTCACAGGAATCTTCAATGAAGATAA TATTCCATTCATTTAGAAATTATTCCTTTTATTTAGAAATTATTTTGAAAAAACTGAAGC TCAAAAAGATGAATAAGTTTTCCAAGGTTACACAGCAGATCAACGAGCCAAGTTTGAAGT CCAGACCCAGCTCTGAGGGTCATACACTGCCTTCCCCAGATTCCTGCACACAGTGACCTA CTATCAGGGCCCTCCTATCTCTCTGGGATCCCCAGCCTCTATCTTTTGTGGCTGCTTTAC AGGAACTCCGAGCTATGGACTCTGCATTAGGAGACGAAGTGCAAAGAGTGTTTCTGTATC CTCCCTCTCTTCTAGGACCCTAGGGCTCTTCCTGGGTCTTTGTGGGTGGTCACAAGCTTT CCTCTCTCAAGACAGCAGGGTTGCATGGTCTTGATAGCCTTGTGATTCGGGTTCTGAGAG ATTCAGGACTGCAAGGGAGGCCTAGACTTTTGATAGCTGCAAGGACTCAGCCAGAGATGG ACCGTAGTGAATGCTCCTTTTTCCTGTAGCTGAAATCAGGGAGAATGACATCAAGCCTGT GCATGATGCTGTCATTCCAAAATCTAGTGATGGGGAAGGTTAGAATCCATAACGTACAAG ATGCACACTGGCTTCAGACAGTTTTATTTAAGATGTGTAGAATAAAGAGGAGGTCAGGCT GGGTAGAACCAGAAGTATCTATTGCCCTGTTCGCGGTCACCTGAGTTATTTCTAATGTTA TGTTATAATAAACACCACAATAGGCTTCTCTTCATAGATGCAAATACTTTTTAGTATTCT TGGTAGAAATTCCTAATGAGCTCAGCTGTCTCTTCAGGGCTTCCCTGCCCAGTCTCTTAA CATTTAAACATGTCATTTACCTTAAAAACATAAGTGCAAACCAACTGATAAAAAACAACC TTGCCTTCAGTCTGCATCCTGTCCCAGAGACACTTTCTTTGTGTCCTCACACGTGGAGCT AAGCTTCTGACTTGTCTCTGGTACATCCCTGAGGATCCTCTCATCTTGGCCATCAGGAAC CTCTACAGAAGGTCAAATTCAGTGGGTTCTTCTCAGTGCCTCTGACTTGAGTTACTAATA ACATTTGCACTATAATCCACTTCTTTCTGATGAACTACCCTGTCCTTATTTTTCTCCTGT TTACCTGGATCCTCCTTATCATCTTTTAAACCACCTCTTAACTATCATGTTCTCTCATTA TACCCTGAGATCTCGGCAATTCTGATTTTTGGCACTCTTCCTGGAAAATCTTATTTAACC TGCACCTGCCACTAATGACTCTCAGTTCTATGGCCTAAATTCCTCTCCTGAGACCACCCA TAATCCACAAATATCTATGTATTATTTCTCCTTAGATGACTTTCAGGTCTTCTAAGTGCA ATAGCCCCACAGTAAACTCAGTATCTTCTCCCGGTCAGGCTGTCTTCCCTGAGAGAAGTG GCTTTTGCCCTGTTTTCTGAATGCCTACATTGAAGCCATCTGTTCCCCAGGAAGCCTTCC CTGATGTGCTGTTTGGTCGCATCTTGTGTATACCTACGTATCTGCACTTATCCTTCTGAA CCTGCTGTTGTCCTGTCACTTGTGTTTCCTTCTGTGACTTATACGCGTCTGCAGAACAGG ACGTATGTATTATTTTTATTTGGGTATTTAGCATCTAACAGTGTTTGACATATAGTAGTC TTTTAATACATATTTTTGTCTGAATGGAAATGATATTTTGAAGAAAAATAATCTGTTCCA TAGCTGGCTGATCTTTGGACTGCAGAACTTGTGAAAGTGTTTTTTAAAAAGCATTTTAAA AAGTACAAGGGACATTCATGTATTAAGAAGATGAGTTTCCAATAACTGCTAGAGGACTTT GTGTCTTTTTATTTTACCCTCTTTTTCCTGATGAGTCCTTTGAGTCCTTTAAACTGAGGA GCAAGCTAAGTTTCCTAGTGAAATACCTATAGGATTTGTTTTGTTTAGTTTCAAATACCA CTCTTTGCTTGGCCACTTACTGTGTCAGGGAGTCATTCTCAGTGAAAAATAAGACACAGG TCATACCCTCTAGACACTTACAATTACAGTGGCAAGGAGTCATTCTCCTGTCACTGTAAG TGGCCAAGCACAGACTGGGTCCCCACATGTCAGGGCTGAAAACTCACAGGGAAATCTGTG AGTTGGGAGGTGAGAGCAGAAGAGTCCCGTAGTTCCTTCTCACTCTGATGCATTTATCAT TCTAAACCCAGACTTTCACATACACATTCATCGTTTTCTTTCATGATAATAGTTGCTTTT ATCCTCTTATCTTTGCTAATTCTTACAAACTAATAAAGACTAAGAAACAAAATAAATTAA ATCCTACAGGTGTTCCAAACTCAGCAATAATTTCTAGTTGGCCTCTAAAACAAAAATCAA AATATAAATGTAAGAAAAGTTTAGAATGCTTAGTACCTGTGTGATGAAATAATCTGTACA CTAAACCCCCAAGTCATGAGTTTACCTATACAACAAACCTGCACATGTACTCCTGAACAT AAAATAAATGTTGAAATATTTTTAAAAAGGAAACAAAAGTTTGGAACAAATGCCAAAATA ACTGTACTGTACTTTTGAATTTATATGCCCCAAATGAAAAATATTATCAACAAAGCTATA CATTCTACAGTTTCATGTTCATAAACTAAGACAGAAACTTTAAAACTGTCAAGAGCCCTA AAATTTGAAGGATATTTTCTTCTTCCTCTCAATTTTGTATTTTTTTCTACCTTTTCTATA ATAAGAAAAAGAAAATGTCCATTCCCCCACCCCCATGACTCTAAAAACAATTTTACATCT GTGTCATAGAAAAATTAAGATCTTAATGGGAGAGAAAACCTCTCTACTAGTTCCGCCAGT AGCCGTATGACCTTAGCAAGTTATTAATATGTAACTTCCCTGCATTTCCTTACCTGTAAA ATGTATGATATGTATTTGCTTCATAGGGTTATTGTGACAATTCAGCGAGTGAAATATGTA AAGTATTTAGAAGGATGCCTGGCACAAGTAAGTGCTCAACAAATGTTAGCTGTCATTGTT ACTATTACTATTGTGTAGGGTCAGGATGCCCAGACTTTCAAAGACCAGGAAGCAGCTTGA CTTATCAGTGATAAACTTTTCATTTTGTTCTTTGCTCCTTTCTTTTTATAACTGCTCATC TGCTCTGTATTATTTCCTTTATGGTGTTGCTCCTTCTTCTTCCCCATATGTCCTTCCTTT GACCTCTTACCTTCTTCCTTTTTATATTCATAAGTCTTTATTCATTCTCTAGCTTTGACC ACTTGCATATTCAAACTGACATTTTGTCGTGTTTTTCTCTACTGTCTTTATGCAGCGGAC CATGTGTCAACTTATGCCGCGTTTGTACAGACGCATAGACCAACAGGGGAGTTTATGTTT GAATTTGATGAAGATGAGATGTTCTATGTGGATCTGGACAAGAAGGAGACCGTCTGGCAT CTGGAGGAGTTTGGCCAAGCCTTTTCCTTTGAGGCTCAGGGCGGGCTGGCTAACATTGCT ATATTGAACAACAACTTGAATACCTTGATCCAGCGTTCCAACCACACTCAGGCCACCAAC GGTACGCCCTATCTTTGCCTCTTCCTCTGTAGCCCAACTGGAAGGGATGAGAGGGCCTCT CTGCCACCCTCAGACTAGGAAGCCTAAGTGCCCCCTGCTGTGTGATCCTCTTCCCCTAGT GGCCATGGGCTGATCCCACTACAGCAAGGGCTTGCATCCTCTCTTCTCAGGAGAGAGAAA GGTGAGCAGAGTGAGGCTGGTCAGTGGTGTGATACCCCTCTCTGTGATTCAGAGCTGCCA TAAAATCTAAGGCTGAGGTAGAGGACCACCCTCCCCTAAGAGGTGGAGCCTTTGTGATTC ATCCCAGAAGAGGGGCCTAACCTGGTGCTGTCTCCTTCCAGATCCCCCTGAGGTGACCGT GTTTCCCAAGGAGCCTGTGGAGCTGGGCCAGCCCAACACCCTCATCTGCCACATTGACAA GTTCTTCCCACCAGTGCTCAACGTCACGTGGCTGTGCAACGGGGAGCTGGTCACTGAGGG TGTCGCTGAGAGCCTCTTCCTGCCCAGAACAGATTACAGCTTCCACAAGTTCCATTACCT GACCTTTGTGCCCTCAGCAGAGGACTTCTATGACTGCAGGGTGGAGCACTGGGGCTTGGA CCAGCCGCTCCTCAAGCACTGGGGTATGCAACTGCTTTTCTCTCCATAATCTCCTGGCAT CCTCTATTCCAAAGACCTGGTGTCCTCTGCACCAGCTTTCCGCACTGGCTGGGTCTCAGT CCTCTCCTCGTCCTAACATCCAATTAACTGGTCCATAACCTTCAATTCCCACAACCATCC CAGGCCATCACCACCCTCACTGCACCTCCTGACCCTATCTCTTCATTCTTCCCCCAGAGG CCCAAGAGCCAATCCAGATGCCTGAGACAACGGAGACTGTGCTCTGTGCCCTGGGCCTGG TGCTGGGCCTAGTCGGCATCATCGTGGGCACCGTCCTCATCATAAAGTCTCTGCGTTCTG GCCATGACCCCCGGGCCCAGGGGACCCTGTGAAATACTGTAAAGGTGGGAATGTAAAGAG GAGGCCCTAGGATTTGTAGAATGTAAGGAAGGGAGGAAAAATTCAATCTGATAAGTGTTC ATTGATCTTCTAATGGGTTAAAAGCATTCAGCCACATAACAACAACAACACCGATAACTA ACTGAGTAGTTAATATGGTCAGGCGCTATTCTGAGGATTTACATTTATTAACTCACTTTA TTCTCACACATAGTCTTTGAGGTAGGTACTATTATTTTCACTATTTCACATGAGAGATAC TTACATCTTTTTACATACACAGAGACTTTAAGCACTTTGATCAAGTTCCCACAGCTATGA AGTAGTAGGGCTAGCTTCCAATCCAGAAAGTCTGGATCCAAGACTGTTTATCCACTGTCC TATTCACCCTATTTTGTGAAGGAAAAGACCAAGTTCAAATTCTCCAGAGTCCATTGCCAA ATAATGGAGTCAGATCTATATTTCTATACATAATTACAACACAGTGTGGTGGGTGCCTGT AACTACTTACTGTCTCTACTTGGACTCATTCCATGGCAATGTTCACACAAAAAATGCCCC TCCAGAGATCTTACAGGTTTCTATTTATCATAACACTCACCATGCTTTATATTTTTATAT GTTTTGGGAATTCTCTTAGCATTAGACAGTGAACTTCCATGCAGATGACCACATCTAATT CATTATTATTATTGTTATTCATGCTGGACCTCAGGTACAAAAGGTTAAGAACTTCTCAGT TCATTATATGATCATCATTGGTGCCTCCGAGCTCTCTCTCTCTCCCTTGATTTATTTGGT CCCTTTTATCTCCAGTCCTTACTCCCATATCTAACCTCTTACCCCTACCTCATAGGTAAA CATTTTAATGAATTTGATGTTTCCTTTTATTTGCATAGATCCTCTGTAATATGTAGTAGT GTCCAGTGTACATGTATTTTTAATTAACCAAAATGGCATTAAATTATAGATCTAATTTTG TACATCCAGTTTGTTTCTTCCAAATCTTCCATAGTATTTTACTTTATATGTCCATGCATT AGTCCATTTTGCATTGCTATAAAGGAATATCTGAAGTTACCTAATTTACGAAGAAAAGAG CTTTAAATGGCTCACAGATCTGCAGGCTGTACGCGAAACATGGCACTAGCATCTGCTTCT GTTGGGGGATTCTGGAAGCTTTTACTCATGGTGGAAGGCAAGTGGAGCCAGTGCATCACA TGGTCATAGAGGGAGAAAGAGACATAGAAAGAGGTGCCAGCCTCTTTTTAACAACCAGGT TTCATGTGCACTAATAGAGTGAGAACTCACTCATTACCCGGAGAGGGGACAAAGCCATTC ATGAGGGTCTCCTCCATGATTCAAATACCTCCCACCAGGCCCCACCTGCAACACTGGGGA TCAATTTTCAACATGAGACTTGGAAGTGACAAATATCCAAATCATATTAATCCACATATC TACATTGCTCCTGGGATACCTGGATCATTCCTGGTTCTCTACTATTGCAAGCAATGCTTG TATCTCACATGGAACTGCATATACATGTGGGCCTGACCTGCATCCCTGGAATGTATGTAT CCTAGAAAGGGGTTGCAGGGTTGCTGGAGATGCAGCTCCTTAATTTGACTAAACACTGCT CATCTTCTCATCAGAATGGCTGTACTCATCTGAACTTCCTTTGTCAGTACTCTAATTGTC CTGCAACTCCTAAATGGACTTCAACACTGGACATTATCCAGTTTTCTAACTTTTGCCAAT TTCATGTGCATAAAGAAATATGCTGTTTTATTTTGCATTTCTTTAATTACTAATAATTGG GGCTATAATTAGGACTGATTAGCCACTTGGGGGTTCCTTTTCTATAAATTGCCTGTTCAC ATTCATTGTCCATTTTTGTACTATGTGCTTCCATCATTTTCTTATTGATTTGCAGGTGAT CCTTATATAGTCCTGCTAGTAGTCCCTTGTCAGTTTTAGGCATTGCAAATGTTTTCCTCT AATCTGACTTCTGGCAACTGTCTCCTTGGTTTCCTTTATTGAAGAGAAATCCTTAATATT TTGTAATGAAGTCCATCAACTGTATTTTTGTTTGTGTGTCTTTTTTAAAAGAAGTCTTCC CTATACTGAGATATCAAAGATACTCTTAAAACATCTCCTACAGTTTTAAATTTCACATTT ACTACTTTAATTCATCTGGGATTCATCTTTGTGTTTGATGGGGATCATGTTTTATTTTTC TTTATATAATGGGCCAGTGTGTTCCCACAACTACTAAATAGTTCACCTTTTCCCCATAGG TTAGTAGTGTCTCCTTTGCTATACTGAAAGCTCCCATTATAGGTGGGCCTGTGTCTGAGT TCCATCTTGTTCCACTGTTCTGTTTGTCTCTTCTTGTGCCAGTGTCCTAGTATTTTGATT ACTATGACATTGTAGTGTGTGTTAGTATCCAGTAGGACAAATTCTTGTTTATTTTTCTTA GTTCACACACATTTATAATTATATCTATAATGATTTGTAACAGAGTGAAGTGAATGTAGA ATGTCAGATGTTAAGAGGAAGAATGGAAAAGAGGGCTGGGACTAGGGTGATGTAGGGGAT GCACCTGGCTTAGGTGCAAAATTTGGGGGATACCAAAAGAACTCAGTAATAAATCATATT TTAATGAAATATCTTGAAAAGGCAAAATTAATGCAAAGATACATGATTAACAAAACATCC AAAGAGGAGTATTTAACAAAAATGGAGAAGCAGAGAAGCAGAAGAATTAGGAGAATATGC TGTCACATGAGCCAAGGAATTAAAGAATTCAGGAAGGAGGAAGTACTGCTGTCAGATGTT CAACAGAGGTCATTTTAGAAAATTTACCTTGGTTTTTGAAATCCTTTCAAAGAGCAGTAT ACACAATGTGAGCAAGTATCCTTCGTTCATTGCCGTCATTGATATGGTTTGGATATTTGT CCCTTCCAATTCTCATTCCAGGGTTAAGCTTCTTCTCTGCCCTCAGTAATGTGGCCCTTC CCCTTGTCTGTATATTTTGGAGACATGAAGCATGTGGGATGGCCTCACAGTCAGCTGGGG TTTGAGGGTGAAATTCAATGACTTTCGTGAACTCCTTGGCTCCTATGTGCTCTTCACCTG GAGGACCAGGGCATGTGCAGGGATGACCACCTTCTCCCTGGGACCTGAACAGGGCAGAGA AATGGGAAGCTCGGGTGCAAAGGGAGTGGGGAAGATGGGTCCGGGCTTACAGTACTGAAC CCAGGAATGACAATAACTGTGTGTGTTGCTGCAGGTGACAAAATATCTGAACAGAAGAGG ACTTAGGAGAGATCTGAACTCCAGCTGCCCTACAAACTCCATCTCAGCTTTTCTTCTCAC TTCATGTGAAAACTACTCCAGTGGCTGACTGAATTGCTGACCCTTCAAGCTCTGTCCTTA TCCATTACCTCAAAGCAGTCATTCCTTAGTAAAGTTTCCAACAAATAGAAATTAATGACA CTTTGGTAGCACTAATATGGAGATTATCCTTTCATTGAGCCTTTTATCCTCTGTTCTCCT TTGAAGAACCCCTCACTGTCACCTTCCCGAGAATACCCTAAGACCAATAAATACTTCAGT ATTTC OMIM ID 142880