Home

Search

Browse

Statistics

User guide

FAQs

Links

Questions

Contribute

Download

Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for HLA-DQA1 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 3117 Official gene symbol HLA-DQA1 Full name major histocompatibility complex, class II, DQ alpha 1 Aliases ,CD,CELIAC1,DQ-A1,FLJ27088,FLJ27328,GSE,HLA-DQA,MGC149527, Gene summary HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq] Location Chromosome: 6   Locus: 6p21.3 Gene position 32605183 - 32611429  Map Viewer Gene orientation plus Gene size 6247 bp Gene sequence >HLA-DQA1:32545183..32551429:Length=6247 ACAATTACTCTACAGCTCAGAACACCAACTGCTGAGGCTGCCTTGGGAAGAGGATGATCC TAAACAAAGCTCTGCTGCTGGGGGCCCTCGCTCTGACCACCGTGATGAGCCCCTGTGGAG GTGAAGACATTGTGGGTGAGTGCATGAGTGAGGGATGTTCTCTGGAGCTGAAAAACAGTA AATTGAAGGAAAAGAGATAAAGCGATTTGCAGAGAAACTGTAGAGATTTCCTAAGGGCCC TTTCAGTATTAAGACAATTAAAAATTATAGCTGTTCCTCCTTCAGGAAACCAGAGCCCCA ACCTACTCTTTTTGTTATCTATGCTGTTGTGTTCACTAAGGACGCTATTCTGTTTATATT ATATTCAGTGACTACGGCCTGGAGGTCTCTATGTCGTTCCATCATGATTGCCTCAAAAAT TAGTGAGGTTTCCATCAGTGGATAATTTTTTATTATTAAAAATTTATGAAGTGTCATTCT CAAATTTCCCTGAACAACTTTTGAAGCTTTTCGGATGTCTCCGGTGGTAGATCTTGGGGT CATTCCATCAATTATGTACTCTATAGATATTTAAAATGTTGCCCGTTTCTTTCTCTCAGA CTTACTCACATTTCCACATGGGAACTGGCACAGGTGGGGAGTGGGTAAAGGAGTCCAGCA GGCTGAATGCCTTCAACAATCATTTTACCACATGGTCCTCACTTACTCTCAGCTGCCTCA TATGTGTCACCTCACAAGTAATCAAATAAAATGGGCATGTGGCTAAGCTTTGTAAATAGT GAAAACATGAATGTCAATTTTTTTTACATATTTCTATTACAGATATAGCTTCACATTTCT TTTCTTTAGCAAAATAAGGGATCATTTTATTTTAAAATTGAGAAGTAGAAAAAATTGGTA AAATAAATCATTTTATTCTCAAATTATCAACCCAAATTACCTGTTCTTCACCTCATCTAA TAAAGTCCTATAAAAAGAAAAGTGGGCCAGACAAGGTGGCTCATGCCTGTAATCCCAGCA CTTTGGGAGGCCGAGGCAGGAGGATCATTTGAGCCTGGGAGCTTGAGACCAGCCTGGGCA ACATAGCAAGACCTCATCTCTACAAAAAAAGAAAAATAAAAATTAGCCAGGCATGGTGGT GTGTGCCTGTGGTGCCAGCTACTCAGAAGGCTGCCGTGGGAGGACCACTTGAGTCCATGA GGCGGAAGCTGCAGTGAGCCATGGTGGCACCACTACACTCCAGCCAGGGCAACAGAGAGA GGCGCTGTCTCAAAAAGAAAGAGGAAAGAAAGCGAGGAAGGAAGGAAGGAAGGAGAAGGA AGGAAGGAAGGAAAAGAAAAGAAAAGGGAAGGGAGGAAGGAAGGGAAAAAGAAAGACAGA AAGAAAGAGGAAGGAAGGAAGAAAGGAAGCACAGATTAATTATTTGGTCTCTTACTCTCC TCTGCCTTTGTCGTCCATCTCTTTCCACCTCTCTTCATGCATCCCTTTCTCCCTCTTCCC TTTCAGGATCCATCTCTGACTCCCTGCTCCTTTATAGAGATGGACAGTGGGTTTGTAAAA CAAAAGTTGAAAAGTCAGATAGTTAAAAGGGGAAGTGAACTGGAAGGTACTTTAAACTTT CACAACTTTATTAACCGTGGCTGCTCCCATTATGATTTTGTTCGGCAGTGGAAGTTTCAC CTGCTTCTCCAGAGCGCTTGGCGTCTTTGTTCCAAATTTCCTTTCTTCAACCTCACACCA GAGTGCCCTGGTCAGGCTTGGCTCATTCATTAGGCACAATGTGGGCAGTGCAGGGGACCC TCCATACTGTAAAGCCACATGAGAAGGTTTTAACTCCTTTTAAAATTAGAAAAATAATGG AATATTAGAGCCTAAGAAAATGTTTTAACTTTTAATTCAGCCTAGATTATATTGTCTTTA TACCAATTCAGTCATAAAATATAATTTTCCATATTTTTGTGGAGGAAGAGGCCCATACAA GCAAGAATGCTCGGGGCTCACATGTCAGAATGCAGCCTTGGTCATGACTGATCCTGGCCT TCGTATGGTTCTGCTACCTGTGTGCCTGCCCGTCTTCCCCAAAATCTATGTGGTCCTCGA ATATAGCAACTGTCATTCAATACACATGTTTGAGCACACAGTGAGCTAAGTTTTAAGGAT TCAAAGATGAAAAGTCATGCTGTCTTCCCTGCAGAGGGTGCTCAGATTAGTGATGGAAAC AGTATGGGGTGCAGGAAAGCAGAAGGCCATTGCTGAGCAGGGCAGTGGACCCAGCAGAGG CTGAAACAATACAAGTGACTTGGTTCCAGGTGGGCCAGCAGGGTGACGTCCTCTAGCAAA ATTTGGCACCCAAGACAAGTACCAGAAGAAAAGAAAGACTGCATGTATTCCACATATATT CATGTTTGAACAAGGAGTCAAGATTTATGGCAAGGATAAGGAGGCTTTGTTGGTGACCTG TTAAGACCAACCAGGGCAGTCATGCTGGATAGGGAAGAAGGTGAGCTGGAAGAGGAACAG ACAACTTGGACAGCCAGATGTTGAGACGGAGGGGTTGGAGGTCATAATGTGGTCAAAAAC ATGTTGATGAGAGGACTCAGCTACAAAGTTGTTAACTTAAGCAGAAACCTCAAGGATGGA TTTTAGAATTTCTCCAGGAAGTCCTAAAAGATAATTCCATTTCAGGGAGAAAAACAACAG ACCACTGCAAAGACCAGGGAACATGAAAGGATAATGTAGTTTGTCTTGCTTGGCAGATAC TTTTGAAGGATGTTGGACTGTAAGGCTGTCGATATCCTCCTCAGAGAACTTACTACAGTA CATTGTATCTGTTCCCTTACCTACCTGACTCTTCCACTATTCAGTTTGTTCCTTAATAGT AGACCATGCCTGATTGGTGTTTTACACATCTCCGGCTATGTCTGACACTTGTGGATGCTC AGAAAGTGGGGAAGGAAGGAAAGATACGATGGTAAAAGGCTTACACATGTCTTGACAAAA AAGTCCAGTTTGGCTCATTTGGCTGGAGTCGTACTGCATGGCTGCCATTCTGCTCTGGCA TCCTCAGACAAGCACACTGCCCATTAGAGGAAAAAGTGTGATATAAGTGTTGAGTCAGAA TGCTGTAGACATTTAGTAATCTCCTTCACAGGAAAAAAAAAAAAAAGGTGGGGGGAATGA CAGAAATCCAAAAACTAGTAGAGCTTCCACTTTTCATTTCAGAAGAAATCAGTTGCTCTC CTCTAAGGACCATTACTATTAACAAAACAGAGACCTTAGAAGGAGGCATTGTTTATTTAT TATATATTTTGTAATGTTATTACCAATCTTGTTATACTCTTTCTTATACCCTACAATTGT TAGCAGAAATTATTTTAAATTAATAAGATCCTGCATGCTTTTCCTTTAAAAAAAAAAAAA AGAAAGATCTCTGTGTAGAGTGTCCTATTCTGAGCCAGTCCTGAGAGGAAAGGAAGTATA ATCAATTTGTTATTAACCAATGAAAGAATTAAGTGAAAGATAAATCTCAGGAAGCAGAGG GAAGTAAACCTAATTTCTGACTAAGAAAGCTAAATACTATGATAACTCATTCATTCCTTC TTTTGTTCAATTACATTATTTAATCATAAGTCCATGACATGCCAGGCACTCAGGAAATAG TAAAAATTGGACATGCGATATTCTGCCCTTGTGTAGCGCACACTAGAGTGGGAAAGAAAG TGCACTTTTAACTGGACAACTACCAACATGAAGAGGGGAGGAAGCAGGGGCTGGAAATGT CCACAGACTGTGCCAAAAAATGAAGCCCATAATATTTGAAAGTCAGTTTCTTCCATCATT TTGTGTATTAAGGTTCTTTCTTCCCCTGTTCTCCGCCTTCCTGCTTGTCATCTTCACTCA TCAGCTGACCACGTTGCCTCTTGTGGTGTAAACTTGTACCAGTTTTACGGTCCCTCTGGC CAGTACACCCATGAATTTGATGGAGATGAGCAGTTCTACGTGGACCTGGAGAGGAAGGAG ACTGCCTGGCGGTGGCCTGAGTTCAGCAAATTTGGAGGTTTTGACCCGCAGGGTGCACTG AGAAACATGGCTGTGGCAAAACACAACTTGAACATCATGATTAAACGCTACAACTCTACC GCTGCTACCAATGGTATGCGTCCACCATTCTGCCTCTCTTTACTTAAGTTATCCCTCCAT ACCAGGGTTCATTATTTTCTTCCCAAGAGGTCCCCAGATCTTCTTATGGCAATTGCTGAA ATTTTATCATCTCCCATCTCTAAAATCACATATTCCCATGTAATACAAGGGTCTTTCCAT TATGCATTCAGCAAATCCTTCTAGGAGAGGTCTCATCAACCTCCTACTTTATTAAACATG CCCACAGAGAGAAGGGCACAGGAATAAAGCAGAGGCAATGTGTCGTTGCTCCCAAGCAGA AGGTAAATAAGACCTCTTTGACTATCAGGTGGTGAAATGCTGGTAGGAGGGCTCTTCCAG GATGTAATGCAGAACTTCAGGGCAGAGCTATTCACACTTCACACCAGTGCTGTTTCCTCA CCACAGAGGTTCCTGAGGTCACAGTGTTTTCCAAGTCTCCCGTGACACTGGGTCAGCCCA ACACCCTCATTTGTCTTGTGGACAACATCTTTCCTCCTGTGGTCAACATCACATGGCTGA GCAATGGGCAGTCAGTCACAGAAGGTGTTTCTGAGACCAGCTTCCTCTCCAAGAGTGATC ATTCCTTCTTCAAGATCAGTTACCTCACCTTCCTCCCTTCTGCTGATGAGATTTATGACT GCAAGGTGGAGCACTGGGGCCTGGACCAGCCTCTTCTGAAACACTGGGGTAAGGATGAGT TTCATCATTTTTTGATTCTTTCTTGTCTGTCAAGTTCAGAACTTCCTGCCTTTTACTCCT ATATCCAAAAACTTGTTTTCCACACTTCATGGGTTTCTTTTCTGTCTCTCTTTTTTTTTT GAAAGAATAAAGCAAAAAAAGCAGAGATTTATTGAAAATGAAAGTACACTCTACAGGATG GGAGTGGGCCTGCCACTTCATGGTTTTCTAATGATAGACTTCACTCTTCTCCCTAAGCCT GGGGCCTTGAGTCTTTGCAGAGCCAACCCTCTACCCCATCCCATCCCACACACATGCACA TGAGCACACTCTGCATTCTGACCTCAACAACTTCACTTCCACAGAGCCTGAGATTCCAGC CCCTATGTCAGAGCTCACAGAGACTGTGGTCTGTGCCCTGGGGTTGTCTGTGGGCCTCAT GGGCATTGTGGTGGGCACTGTCTTCATCATCCAAGGCCTGCGTTCAGTTGGTGCTTCCAG ACACCAAGGGCCATTGTGAATCCCATCCTGGAAGGGAAGGTAAGATTGAGACTGGTTACA GTTGAAGCGGCAGTATGAAAGGAAGGAAAGTGGGAGGGCGTTGTGGACATGAATGTGGTT GAAAGTTGTAGGGGAATTGGGAAGTGGCATGATGATGACACAGGAGCCCCCTCGGACCCA TTGATCTCATGTCTGCCCTGTTGCAGGTGCATCGCCATCTACAGGAGCAGAAGAATGGAC TTGCTAAATGACCTAGCACTATTCTCTGGCCCGATTTATCATATCCCTTTTCTCCTCCAA ATATTTCTCCTCTCACCTTTTCTCTGGGACTTAAGCTGCTATATCCCCTCAGAGCTCACA AATGCCTTTACATTCTTTCCCTGACCTCCTGATTTTTTTTTTCTTTTCTCAAATGTTACC TACAAAGACATGCCTGGGGTAAGCCACCCGGCTACCTAATTCCTCAGTAACCTCCATCTA AAATCTCCAAGGAAGCAATAAATTCCTTTTATGAGATCTATGTCAAATTTTTCCATCTTT CATCCAGGGCTGACTGAAACTATGGCTAATAATTGGGGTACTCTTATGTTTCAATCCAAT TTAACCTCATTTCCCAGATCATTTTTCATGTCCAGTAACACAGAAGCCACCAAGTACAGT ATAGCCTGATAATATGTTGATTTCTTAGCTGACATTAATATTTCTTGCTTCCTTGTGTTC CCACCCTTGGCACTGCCACCCACCCCTCAATTCAGGCAACAATGAAATTAATGGATACCG TCTGCCCTTGGCCCAGAATTGTTATAGCAAAAATTTTAGAACCAAAAAATAAGTCTGTAC TAATTTCAATGTGGCTTTTAAAAGTATGACAGAGAAATAAGTTAGGATAAAGGAAATTTG AATCTCA OMIM ID 146880