Home

Search

Browse

Statistics

User guide

FAQs

Links

Questions

Contribute

Download

Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for HLA-DQB1 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 3119 Official gene symbol HLA-DQB1 Full name major histocompatibility complex, class II, DQ beta 1 Aliases ,CELIAC1,HLA-DQB,IDDM1, Gene summary HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq] Location Chromosome: 6   Locus: 6p21.3 Gene position 32634466 - 32627657  Map Viewer Gene orientation minus Gene size 6810 bp Gene sequence >HLA-DQB1:complement(32567657..32574466):Length=6810 TTTTTATTCTTTCTGCCAGGTACATCAGATCCATCAGGTCCGAGCTGTGTTGACTACCAC TGCTTTTCCCTTCGTCTCAGTTATGTCTTGGAAGAAGGCTTTGCGGATCCCCGGAGACCT TCGGGTAGCAACTGTCACCTTGATGCTGGCGATGCTGAGCTCCCTACTGGCTGAGGGCAG AGACTCTCCCGGTAAGTGCAGGGCAGCTGCTCTCCAGAGCCGCCACTCTGGGAACAGGCT CTCCTTGGGCTGGGGTATGGGGGATGGTGATCTCTATGATCTTGGACACAATCTTTCATC AACATTTCCTCTCTCTTGGGAAAGAAAGCTATGTTGCATTCCCATTTATCTTTTAGTGAT GAGATGAGGACAATCCAATCCCCATCCTACAGGCTTAAGCCTGGAAGAGGAGGAGAGAGG AGAGAAAGAGGAGATAAAGTGTACATTTACTACCAGCGATAGGACAAAGTGAGCATGGGG TTATTTTTGAAGATATGAATTTCTCCAAAGACACAGCAGGATTTGTCATTTAGGCGTGCC CCAAGACTGCCTGGACTTAGGATTATGAGATCCTGCATTGGAAAATGTGAGGCAGCAATG GTGTCTGTAGTCTCTGTATTTGAGGAAAATTTGTCTCTATTCCTGACCGAGTGGAGCATT TGTGGAGGCAAAATCTTGGTGCTGAGGGAAGCTGACTGGCTGACCACAGAGAGGGAGTCT TCGGGTTTCACTGATTTATGGGCAAATGGTGACTTGAGTGGGATTCAGAGACCCGAGTTA ATGGTGGACTGAATTTAGTAGGAAGGAGGATGTAAAGAAGGGAAATAACACATATTGTGA AACCACTCACTTCAGACAGAACAATACTTTATATAACTTCTCTCTCACTCCTTCTAACAT CCTGTGTGTAGATATCATGATTTTCTTTTACACAATTATACTTGTGATATGGATATTCTG TTACATAACCTGCCCAAACTGGTGACTGCCACAGTTTAATTGGAATCTAGTTTATCAAAT TCAAAAGCTTGTGCTCTTTCCATGAATAAATGTCTCTATCTAGGACTCAGAGGTGTAGGT CCTTTCCAACATAGAAGGGAGTGAACCTCAACGGGACTTGGGAGGGTAAATCTAGGCATG GGAAGGAAGGTATTTTACCCAGGGACCAAGAGAATACGCGTGTCAGAACGAGGCCAGGCT TAATTCCTGGACCTATCTCGTCATTCCGTTGAACTCTCAGATTTATGTGGATAACTTTAT CTCTGAGGTATCCAGGAGCTTCATGAAAAATGGGATTTCATGCGAGAACGCCCTGATCCC TCTAAGTGCAGAGGTGCATGTAAAATCAGCCCGACTGCCTCTTCGCTGGGTTCACAGGCT CAGGCAGGGACAGGGCTTTCCTCCCTTTCCTGGATGTAGGAAGGCAGATTCCAGAAGCCC GCAAAGAAGGCGGGCAGAGCTGGGCAGAGCCGCCGGGAGGATCCCAGGTCTGGAGCGCCA GGCACGGGCGGGCGGGAACTGGAGGTCGCGCGGGCGGTTCCACAGCTCCAGGCCGGGTCA GGGCGGCGGCTGCGGGGGCGGCCGGGCTGGGGCCTGACTGACCGGCCGGTGATTCCCCGC AGAGGATTTCGTGTTCCAGTTTAAGGGCATGTGCTACTTCACCAACGGGACGGAGCGCGT GCGTCTTGTGACCAGATACATCTATAACCGAGAGGAGTACGCGCGCTTCGACAGCGACGT GGGGGTGTACCGCGCGGTGACGCCGCAGGGGCGGCCTGATGCCGAGTACTGGAACAGCCA GAAGGAAGTCCTGGAGGGGACCCGGGCGGAGTTGGACACGGTGTGCAGACACAACTACGA GGTGGCGTTCCGCGGGATCTTGCAGAGGAGAGGTGAGCGTCGTCGCCCCTCCGTGAGGCC CACCCTTGGCCGAGACCCCGAGTTTCTGTGCCGGGAGGGGCGATGGGGGCGAGGTCTCTG AAATCTGAGCCCAGTTCATTCCACCCCAGGGGAAAGGAGGCGGCGGCGGGGTGGTGGGGG CAGGTGCATCGGAGGGGCGGGGACCTAGGGCAGAGCAGGGGGACAAGCAGAGTTGGCCAG GCTGCCTAGTGTCCCCCCCAGCCTCCCCGTCCGTCGGCCTCGTCCTCCGCTCTGCACGTT TCTCGCCTCGTGCCTTATGTGTTTGCCTCCTCGTACCTTACCTTCGCTAAGCAGTTCTCT CTGCCCCCAGTGCCCACCCTCTTCCCCTGCCCGCCGGCCTCGCTAGCACTGCCCCACCCA GCAAGGCCCACGTGCGCAGCTTGCGCCGCAGGAAGCTTCAGGCTTGGCCTGGTGGAGTTA GGGCTGCCCCACAGCTGCGCGCAGGGCATCCAGCAATTACAGTTGCGAAATAAGATATTT TGACTTTTTGGCTTCAAATCATTATTCATCGTAATTCTGTTTTCTTAAATGGCTACCACT AATGGCGGAGATCTTTGAGGCGAGAGACTGTTTAATTATTGCATGCCTGGTACCTGACAC ATTGACTGGTATGTGGTGTGAGCTCAATGATCTTCTGTTAAATTCATGAATAAATGTACT CAGCTGCCAATCCAGTTAGGTTCAAGAAAAAAACAGAGGCTTACAAATGAACTTTATCAA TTATTTTCTAACATTTTGCTTAATGCTTTCAAGTAAACTCTTACTGACTTGGATCTTAAT AGAATTTGTGAATACAAAGTCTGAGGAAAATGTGTTTGCTAAAAATAAAAACAATGCTTG AATGATGTTGTAAGGCAGAGTTTTAATTTCTTAGAAAAGCTGAACAAATAGCACTATGCA AAGATCAGAAGTTTGGGAATAAATAGGTTGAAGCTATTAAATTATTGGATAAAAATAGTT TCAGGTTGCTTTTGGCCTAGGTTATCCCCTCCCCCCCATCACTATCCACTTCAGGAATAA ACATTCTGAAAGTCAATTTTACCCATTCAGGAAGCACTTATTTCTAGACAGTTGCCTTAT CAAATACCATCTATGTTATGTCATTTAATCTCACAGCTACCTGTGCATTAGAGATTAGCA TCACCACTTTATATATCCTAATATTGGTACATGATAAACACTTTAAGTAATCAGCCCACA ATTACTCACCAAGATCTTAAGCCTCCCAAAGTACACAACATTCTTATGTTCCTCACTACA CATATGTAGAGTCTAAGGGATGTAAGGCCTTGTTAAAGCCAGTTTTGACCAGAAGCAGCA ATGAGTCTATTCCTGTTTGTTCTGTGTGTTAATGCGGCATTGAAAATTCATGATTAATCA ATCCCTAGTCTGACCCCGGTGTTATCTATGCAGGTTCACAAAACTTTTAGTTTGCTTTAC ACTCCCTTGCCTTCTTTTGACTCACATCCTAATGCCAGCAAGTACTTATATTTTTGCTAT TTCAGTTTTATTTCCATAAAATTTATTTTATCATCTTTTCTCATAAATTTGTGCCCTCTA TTTTTACTCCCAGTCTGTTGAAGATGAACAAATCTTATAAGGCCACATAGCTGACTCTGA TTTCAGTTGGCCTCCAGGAAGGAGAACCTAAAGAAAAGTTCAAGTCCAAGCAGAAACCAT GATTCCTTCCGGATGATGGCTCAAGAGTGCCATTTAATTGGGGTGCCACCTGCTGACCTC AGCAAATCCCAGTTATATGTATATGTTCACATTACAGGCTCATTAGCCCAGGCCGACCTC TGCACGGATCTCAGAATATTTTCTGTGGAGAACATACACGATAATGTCTGATTTCAGAAC AAGAAAGTAATTGTCAATAGCAAGGAAATGGAGTAGGGTAGACAGCTAGTAATTAAACTC ACTTGTGCGTTAAAAAGAAATTAAGGAAAAAAAGAAAATGAGAGAACATATTACTAAATA AAGAAAGCACACATTAAATATTTGCTATAGTTTCACACTAAGAGAATAAAGGAAATGTGA TAAAGTGGCCTAAAAGGAAAGGATGAGATGTGTAAAAGAGGCGGGGAAAGATGTGTCATT TTTTTTACTATGAGCAGCAATCTGAGAAGATAAAGGAATTGAGTTGTGGACAAACATGAT GTTTGATCAAGGGTTATTTGTTTTGAAGGCCTGCCTACTTTTTTTTCAAATATTACAAAC TTTTGAAATAACATTCTACTTTTTTTTCAAATATTACAAACTTTTGAAATAACATTCTTT TTGTTTTTTGCTGTCTGTTACTAGATTGCACATTCTATAAATGCAGGGACCATAGTATGT TATTTATCTTTGAATTCTCAGTGATTGTCAAATTTATATTTGTTGAATGAACCTTAATCC AAGACTTCGACTCCAGGTATCTTTCCACTCTGGTCCAAGGAGGGATCCTTCCTCATGGTA GACGTGGTGTGTGTTCTCACATCTCACTCCTATGTCTTTTCCTGTCTGTTACTGCCCTCA GTGGAGCCCACAGTGACCATCTCCCCATCCAGGACAGAGGCCCTCAACCACCACAACCTG CTGGTCTGCTCGGTGACAGATTTCTATCCAGGCCAGATCAAAGTCCGGTGGTTTCGGAAT GATCAGGAGGAGACAGCCGGCGTTGTGTCCACCCCCCTTATTAGGAATGGTGACTGGACT TTCCAGATCCTGGTGATGCTGGAAATGACTCCCCAGCGTGGAGATGTCTACACCTGCCAC GTGGAGCACCCCAGCCTCCAGAGCCCCATCACCGTGGAGTGGCGTAAGGGGATATTGAGT TTCTGTTACTATGGGCCCACAAGACAAAGAGCTCCTTCTGACCCATTCCTTCCCATCTCT TATCCCTGATGTCACTACTGAGCTGGGAATCACAGGAGACTAGAGCACCTCTTGCTCCAT GGCAAGTGCATCAGAAGAATCCTGGTCTCATCACCTTTCCAGATGCTAGGGAAATTACTC TACATACTGTTGCTCTGAATCCCAGTCCTGATAGCTCTGAGGGACTGATTCTTAGGGCTG GTGACTGGGATCTTAGGGTCTAAGGTTATGGATGAGTTCTTGAAGAGCAGAGATTTGCTT CCCCACTCTCTCACCTATTCACTGTATCCAAGGACCTATTGGCTGGTCTTTCCCCTCCTT AGGGGTGGTCTGAATGGAGAACTAGGTTCCTTTGATGCCTTCACCTTCTGCACCTCAGAC TGGACTTCAACTCCTCAGCAGGGATGCTATGGGGTGTGGGGACAAACACAGACACTCAGT TCTGCTCTTTAGGGGCTCAGTCTGAATCTGCCCAGAGCAAGATGCTGAGTGGCGTTGGAG GCTTCGTGCTGGGGCTGATCTTCCTTGGGCTGGGCCTTATCATCCGTCAAAGGAGTCAGA AAGGTGAGGAACCCCAGGGGAAAAGGGGAAGATGGGCTGTGACCCAGACCCTCTGTTCAG AGTGGTCCTGTCTGTAGATTAGCTCTTTCCTCCTGACCCTGAGAAGAAGTGCGAGGAGAC AGGACAAGATGGGAGGAGGCATTGGAATCTGATTTTACTGGTTGAAAGGTAGCGCTGTCA CAGAGCTGACTGATAGAGCTTATTCCAGGGCATCCTTACCATTCATCATTGTCTCACTGG CTCCTTTCCAAAAGCTTCCTCCATTAAGAGGGTCAGAGCCTCAGCTTCCTTTCTTTCTAG TGACAATTTCCTTTGTTTTAGGGGATTTTAAATTAGGGTGCTGAAGGCCTGGAAGAACAT GGGTGGGAAGAGAATGTAACTCTAAGTCATGTGTGTCATTTTCCTTTGGGGTGAGAGAGT GGCTGTTTGTGTAATGAGACCTTTCTCTGCATAACTTCCTTTTGTAAGACCTCAAGGGCC TCCACCAGCAGGTAATATTTCAGCCATGATCCAGTGTGGGGAGGCACAGGTATAAGAGGG AAGAGCATGAGCTGAGTGTACCTGACCACAGTGGTCCATGTTCATGGCCTATTTGCTGCT ATGAGGATCAAGACTTAGGGGAGAAGTTTGCCAGTTTCTAGGAATCTCCAGACATTGTTC CCCAGAACCAAGCCTTAACTTTGGTGGCATCTTCTTGTGAAATGTGGAGCCAGAACCACA GCTTAAATGTTAGACACTAGGATGATGCCCACTTTGTGCCACATGATGGTGGCTACTGCC TGTAAGCATTTTCCAGTGACTGAAAGAGGCTGCTAGTGGTCGGGAAGAGATATCATCCAA TTTCCTAAAAAGACTGAACCCTTCATATTCCCCAGAAGAATAACAGCTGTTCCCCACCTC CCACACATCTGCATCAAGCTGAAGTTCTGTGTCCTCATGAGCTGATTTCACCTTTGCACA GATCTTGGGGGAGGTGATGACAATACACCCTGGACCTCAACTTTCTCTGTCTGAAGCTGC AGGGGGCCCCTGAAGGGTGGGGGAGATGGCAGGCCCACCAGGATACCCTGTGCTGATCAA TGCTCTTCTCTCTTCTCCAGGGCTTCTGCACTGACTCCTGAGACTATTTTAACTAGGATT GGTTATCACTCTTCTGTGATGCCTGCTTATGCCTGCCCAGAATTCCCAGCTGCCTGTGTC AGCTTGTCCCCCTGAGATCAAAGTCCTACAGTGGCTGTCACGCAGCCACCAGGTCATCTC CTTTCATCCCCACCCCAAGGCGCTGGCTGTGACTCTGCTTCCTGCACTGACCCAGAGCCT CTGCCTGTGCATGGCCAGCTGCGTCTACTCAGGTCCCAAGGGGTTTCTGTTTCTATTCTT TCCTCAGACTGCTCAAGAGAAGCACATGAAAAACATTACCTGACTTTAGAGCTTTTTTAC ATAATTAAACATGATCCTGAGTTATCTGTA OMIM ID 604305