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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for HLA-DRA (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 3122 Official gene symbol HLA-DRA Full name major histocompatibility complex, class II, DR alpha Aliases ,HLA-DRA1,MLRW, Gene summary HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq] Location Chromosome: 6   Locus: 6p21.3 Gene position 32407619 - 32412823  Map Viewer Gene orientation plus Gene size 5205 bp Gene sequence >HLA-DRA:3878074..3883241:Length=5168 TTTTAATGGTCAGACTCTATTACACCCCACATTCTCTTTTCTTTTATTCTTGTCTGTTCT GCCTCACTCCCGAGCTCTACTGACTCCCAACAGAGCGCCCAAGAAGAAAATGGCCATAAG TGGAGTCCCTGTGCTAGGATTTTTCATCATAGCTGTGCTGATGAGCGCTCAGGAATCATG GGCTATCAAAGGTAGGTGCTGAGGGAATGAAATCTGGGACGATAGACTACGAAGCATTGG AGAAAAGACCTATGGACATTTGGAAGATAATGTGTGGAGTGAAAGAATAGTGTGACAGGT ATTATGTGGTCTCGACAGAAAGTATAACAAATTGTGGTTTGGTGGAGTTCTTCCCTCACC ACAAACTGAAGTAAGTCAAATTTGGTTTAGAGGATCAAAACTGAGTTGTGTATTGATGAA TAGCAAGGTCCTGCTACAAGCCAAACTGGGGGTGGGGGTGGGGGTGGGGGAGGAAGAATA TTTTCTGGCAAGCATTAACAAGTTATATTTCTGGGCTTTAATTATTCTTTCTGGAAAATT AGTAAAATTAAAAACTAAAAACCACACATAGTTTTGCTAGAATTAAATGAAAAAAAAAGT TATTAGCCCTGTTCTTATCTGAATACATGATACAGTAGTTATTTTTTGGAGTGTAAATCC TGTCGGTATATATTGAGCACATATATTGTGTTGAAGATTACTAGAAGGAAAAGTCATCAA AAAGCAACAATTTACCCCAGGAAAAGGGGAGGGAAGGCATGCTGATATGAGTTGCCTCAT GGGACAGTGATAGCCATTCCCTGCCTTCCCATCTCCATGGTACAGCAGATCTTATATCAT GTTAACTTAGTAATATTTCCAAGAGAGTAGAAAAATGAGTAAGGAAATGGGGAATCTGAT ATTATTCTCTCTCATCTCCAGAGCAACATTGGTGCTGTTGTAAAGATGTACTGTAGAAAA GTATTCTTCACCCAGCATGACCCCCACAGAAGGTGTCAGGTAGACTTGAAATAAGCAAAG TAATAACCCAGCTCCCATACCCATAGTGGCAATTGTAGATTTCTATTGCCCCAAAAGAGC CATACATAGGGATACTTACCTAGAAAGACAGAGGCTCTTCCCTTGGTTTGTGAAGAGGCA GCTAGTATATTTGTGTGTGTTTGCATAGATGCAAACGGTAAATAAATTCCTAGGTTTATC AATACACAGTCAAACATTAAAGTCTCTCATCTTGGCTGGGCACGGTGGCTCACGCCTGTA ATCCCAGCACTTTGGGAGGCCGAGGCAGGCGGATCACGAGGTCAAGAGATCGAGACCGTC CTGGGCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCTGGGTATGGT GGCACACGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGGATTGCTTGAGCCCA GGAGGCGGAGGTTGCAGTGAGCTGAGATGGTGCCACTGCACTCCAGCCTGGCGATAGAGC AAGACTCCGTCTCAAACAACCAAACCAAAACAAAACAAAATATCTCACCTTATCTTTGAA GACTAAGGAAAAAAAAATCTCCCACTCATCGATACACTCCACAGAGGCAGCATACTCTCC AAGTGTAGCTTTCTCTTTTCATGTTCATTATTCCCTTGGTGTTGGTTATTCTCAATGTCA ATCATAACAGAACATCTTCCATAATAACAGTCCCAATTTAAGGAGCATTAAGATAAAAGG TGGAATTGCCAAGGTCAATCCAGACGAGAACCTTCTCATAGAGGTAACCACCGTGTGGGT TTGGATGCTGGGAAGCAGGGGGACTATGACGCTACAAGGTCTCAGTCTTAATTTTTGGAG TATTTCAGTCCCCAGGTATATTTTCCATAGATTTGGCCCTTAAATAAAAAGAAGCTTCTG ACTCTAAAATGTAAACAGTGCTTGTTACAGTCTTGTTGATATATTAAGAAATTACTCACC TTATCTCATTTAATCTTAAAAACAAACCCCTGACAGGATCAAAACCACAGCAGGGCTACA TAATAGGAAAACTATACATAAATAGGTAGAATAATCTGCTCAGGATCACTAGGTAAGTTG CTGAATAAGAATTCAAGATGTTTTTGATCCCAGAGTTTAAAACCCAACCTTTCAAACAGC GTTTCTTTCTTCTTAGAGTACAATGTTCTGAGAAAGAGATCCTCTGGAATTCTGGCCTAA GTGTATTTAATGCCCGGGTAAAGAAAGTGAGAGAACATTTCTCTTTAGGGGCTGCTGCTG GATTTCTAAAAAGAAAATAATTTCTCAGCTAGTAACATGGAGCCAAACAACAGCTTCACA AGACTCTGGGTTCTTTAGCCCTCATCTCCTTCAATCCACCCTCTTTATAACCAGTCCTTC TTGTTTTTCCCCTCCCAGCTTTGTTCAGCAGCATGCCCTTCACCCAGACCTTGTCTTGTC ACTCATCCCTACTCGCCATCATTCTTTCATTCCTCTTGGCCCAATCTCTCTCCACCACTT CCTGCCTACATGTATGTAGGTTATTCATTTCCCTCTCTTGATTCCCCCCACCCAACTCTC TTTCTCCACTTCTCGCCTTTCAGAAGAACATGTGATCATCCAGGCCGAGTTCTATCTGAA TCCTGACCAATCAGGCGAGTTTATGTTTGACTTTGATGGTGATGAGATTTTCCATGTGGA TATGGCAAAGAAGGAGACGGTCTGGCGGCTTGAAGAATTTGGACGATTTGCCAGCTTTGA GGCTCAAGGTGCATTGGCCAACATAGCTGTGGACAAAGCCAACCTGGAAATCATGACAAA GCGCTCCAACTATACTCCGATCACCAATGGTACCTCCCTCTCTGCTGCACTCCTGGACAT GGGAATCCATAGTTTGAAAGTAGTTGCTTCAGCTCTTTGTGTTAGATTATTGTAACTGAT TTTCCCTCCAAGGGCCTAACCTTGCCATTAACAAGCCCCAAATTCTCATGCCAGAGGTCT GAGAACTTTATGGGTTTGATCCTATCTTGTTGTGCTCAAGTCTTGTCTCTGTCATCCATG GTCTCCTACAAAGTCATTGCCCTAAGTTCATGCTGGGGGAGCCAGAAGGGAAGTCCTTGG ATATCTTATACCTCAATATTGGCTCAATTTCTTGGGGAGGGGGTGCTGTCAGAGATTGTT ATCTGAGGATGTGACATAGATTTCTCAGGGCACAATTTCAACTACTTTTTCAGCTTTAGG GTTTTTAGATACGTTTGTACCACAATTGAGCATGGGAGGGAGAGGGGTGAGCCTAAGCAG TGATGGCTGATTTCTGTCATGTCTGTCATGTGTCCCCCAGTACCTCCAGAGGTAACTGTG CTCACGAACAGCCCTGTGGAACTGAGAGAGCCCAACGTCCTCATCTGTTTCATAGACAAG TTCACCCCACCAGTGGTCAATGTCACGTGGCTTCGAAATGGAAAACCTGTCACCACAGGA GTGTCAGAGACAGTCTTCCTGCCCAGGGAAGACCACCTTTTCCGCAAGTTCCACTATCTC CCCTTCCTGCCCTCAACTGAGGACGTTTACGACTGCAGGGTGGAGCACTGGGGCTTGGAT GAGCCTCTTCTCAAGCACTGGGGTATGGACCAACACTCAATCTCCTTTATTTCAAGGTTT CCTCCTATGATGCTTGTGTGAAACTTGGTGTTCTAACTGTTTCATAATATCTGCTACAAT TAATATAACTGTCTTCTCCTACTATCCAGCTTCCGCCTTTTTTTAATCTGTAATTCTCTC AATACATCATTCTGTCTTCCTCTTCTTTAATCTATGAATAACTTTTCTCTTTATTAAGAA CCCTACATTTGATTCTGAGTGTTACTTCTTCCCACACTCATTACCATGTACTCTGCCTTA TTTCCCCCCAGAGTTTGATGCTCCAAGCCCTCTCCCAGAGACTACAGAGAACGTGGTGTG TGCCCTGGGCCTGACTGTGGGTCTGGTGGGCATCATTATTGGGACCATCTTCATCATCAA GGGATTGCGCAAAAGCAATGCAGCAGAACGCAGGGGGCCTCTGTAAGGCACATGGAGGTG AGTTAGGTGTGGTCAGAGGAAGACATATATGGAGATATCTGAGGGAGGAAAACAGGGTGG GGAAAGGAAATGTAATGCATTTAAGAGACAAGGTAGGAACAGATGTGGCTCTTGATTTCT CTTTGCTAGAACGAATCAGACATTGGTATCATCTGGTATCCCAAAGCTTCAGGGTCTGTC ATCCCTTTCTATAGACGGGCACCTTGATCACGGCTCCAGTCTTAGAAATCATCTCCAGTA CCTAAAACCATTGTTTCACATTAGAATACTGAGTCTAGGGATCTAGAAAATACTGAGTCT AGGGATCTAGAAAAATAAGCCTCAAGATTTGGGCACATCCTAGCTTGTATTTCCTGGGGC AGGTCATCAGTTCAGAAGCATTTCCAGATCCTGGCTCCTTTCAGGTTAGGGTCAATTCAT TGCATGAAATGGGAATCTCTTAGAGGCCAATGCCTGCTTTTGCTTCTTTAGTCTCAAATG TAGTATGAGAAACTCTAAAAAAAGGTAAAGCATGGTTGCTTATTATGTTCAGTTGGAGAG TAGGGTATACAGTTAGTTCATGTTGGAAAGGTTAGATGAACATTGAAAGAATTTTGCAAA GTCAAAGGATTAAGAGAGAAGAGGAAGGAATCTGAAGCAAGGAGCTCAAAACTGATCTTA AACTCCTTGGTAACTATGTGTGTCTTGCTATAGGTGATGGTGTTTCTTAGAGAGAAGATC ACTGAAGAAACTTCTGCTTTAATGGCTTTACAAAGCTGGCAATATTACAATCCTTGACCT CAGTGAAAGCAGTCATCTTCAGCATTTTCCAGCCCTATAGCCACCCCAAGAGTGGTTATG CCTCCTCGATTGCTCCATACTCTAACATCTAGCTGGCTTCCCTGTCTATTGCCTTTTCCT GTATCTATTTTCCTCTATTTCCTATCATTTTATTATCACCATGCAATGCCTCTGGAATAA AACATACAGGAGTCTGTCTCTGCTATGGAATGCCCCATGGGGCATCTCTTGTGTACTTAT TGTTTAAGGTTTCCTCAAACTGTGATTTTTCTGAACACAATAAACTATTTTGAAGATCTT GGGTGGAA OMIM ID 142860