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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for HLA-E (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 3133 Official gene symbol HLA-E Full name major histocompatibility complex, class I, E Aliases ,DKFZp686P19218,EA1.2,EA2.1,HLA-6.2,MHC,QA1, Gene summary HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. [provided by RefSeq] Location Chromosome: 6   Locus: 6p21.3 Gene position 30457183 - 30461982  Map Viewer Gene orientation plus Gene size 4800 bp Gene sequence >HLA-E:1969247..1974046:Length=4800 GCAGACTCAGTTCTCATTCCCAATGGGTGTCGGGTTTCTAGAGAAGCCAATCAGCGTCGC CACGACTCCCGACTATAAAGTCCCCATCCGGACTCAAGAAGTTCTCAGGACTCAGAGGCT GGGATCATGGTAGATGGAACCCTCCTTTTACTCCTCTCGGAGGCCCTGGCCCTTACCCAG ACCTGGGCGGGTGAGTGCGGGGTCGGGATGGAAACGGCCTCTACCGGGAGTAGAGAGGGG CCGGCCCGGCGGGGGCGAAGGACTCGGGGAGCCGCGCCGGGAGGAGGGTCGGGCCGATCT CAGCCCCTCCTCGCCCCCAGGCTCCCACTCCTTGAAGTATTTCCACACTTCCGTGTCCCG GCCCGGCCGCGGGGAGCCCCGCTTCATCTCTGTGGGCTACGTGGACGACACCCAGTTCGT GCGCTTCGACAACGACGCCGCGAGTCCGAGGATGGTGCCGCGGGCGCCGTGGATGGAGCA GGAGGGGTCAGAGTATTGGGACCGGGAGACACGGAGCGCCAGGGACACCGCACAGATTTT CCGAGTGAACCTGCGGACGCTGCGCGGCTACTACAATCAGAGCGAGGCCGGTGAGTGACC CCGGCCAGGGGAGCAGGTCACGACCCCTCCCCATCCCCCACGGACGGCGCGGGTCCCCTC GAATCTTCGGGTCCCAGATTCACCCCAAGGCTGCGGAACCCGCCCAGACCCTAGACCGGG GAGAGTCTCAGGCGCCTTTACCCGGTTCTTTTTCAGTTTAGGCCAAAATGCCCACAGGGT GGTGGCGACGGGGGCGGGGCTTGGTGGGCGGGACTGACTAAGGGGCGGGGCCAGGGTCTC ACACCCTGCAGTGGATGCATGGCTGCGAGCTGGGGCCCGACAGGCGCTTCCTCCGCGGGT ATGAACAGTTCGCCTACGACGGCAAGGATTATCTCACCCTGAATGAGGACCTGCGCTCCT GGACCGCGGTGGACACGGCGGCTCAGATCTCCGAGCAAAAGTCAAATGATGCCTCTGAGG CGGAGCACCAGAGAGCCTACCTGGAAGACACATGCGTGGAGTGGCTCCACAAATACCTGG AGAAGGGGAAGGAGACGCTGCTTCACCTGGGTAAGAGGGTCCACAGGGCTACTCTCCCAT CTCCTTCTTGGGCTAGGACTGTGCCCACAGCTGACAGACCTCAAACAGTAGAAGAAACAG GGATGGAGGCCAGAATACCACTCCTCCCTTGGATCAGGAGAGGGAGCTGTCACCTGAGGT ACAGGAGATCCTATACCACAGAGTGACTCTCTTAAAGGGCCAGACCTCTCTCAGGGGCAA TTAAGGAATCTAGTCTCGCTGGAGATTCCATCCTTCAGATGAACTGATGAGCAGTTCTCT TTGACTCCCAGTATTAGGAATCACGGGGGAGTTTCTCTCGTGCCTGATTCTCAGCCCCAC ACCAAGAGTTTTTGGAGGTCTGACTCCAGCTTTTCTCAGTCACTCAGCATCCACACAGGC CAGGACCAGAAATCCCTTTTCACCTTCTACCCTGGGCTAGCTCATCCCGATTCTAGAACT TTCCAAGGAATAAGAGGCTATCCCAGATCCCTAAGTCCAGGCTGGTGTCAAGGTTTTGTC CTCTTCTCCTACTATAATTGTCCTCTTCCTTCTCAGGATGGTCACATGGGTGCTGCTGGA GTGTCCCATGAGAGATACAAAGTGCCTGAATTTTCTGACTCTTCCCCTCAGAGCCCCCAA AGACACACGTGACTCACCACCCCATCTCTGACCATGAGGCCACCCTGAGGTGCTGGGCCC TGGGCTTCTACCCTGCGGAGATCACACTGACCTGGCAGCAGGATGGGGAGGGCCATACCC AGGACACGGAGCTCGTGGAGACCAGGCCTGCAGGGGATGGAACCTTCCAGAAGTGGGCAG CTGTGGTGGTGCCTTCTGGAGAGGAGCAGAGATACACGTGCCATGTGCAGCATGAGGGGC TACCCGAGCCCGTCACCCTGAGATGGAGTAAGGAGGGGGATGGGAGGTCATGTCTCTTCT CAGGGAAAGCGGGAGCCCTTCTGGAGCCCTTCCGCAGGGTCAGGGCTGAGGCCTGGGGGT CAGGGCCCCTTACGTTCCCCTCTTTTCCCAGAGCCGGCTTCCCAGCCCACCATCCCCATC GTGGGCATCATTGCTGGCCTGGTTCTCCTTGGATCTGTGGTCTCTGGAGCTGTGGTTGCT GCTGTGATATGGAGGAAGAAGAGCTCAGGTGGGGAAGGGAGAAGGGTGGGGTCTGAGTTT TCTTGTCCCACTGGGTGTTTCAAGCCCTAGGTAAAAGTGTGTCCTGCCTCGTTACTGGGA AGCACCATCCACACACACGAGCCTACCCAGCCTGGGGCCCTGTGTGCCAGCACCTACTCT TTTTTTTTGAGACGGAGTCTTGGCTCTGTCACCCAGGCTGGAGTGCAATGGCGTGGTTTC AGCTCACTGCAACCTCCGCCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCTAGT AGCTGGGACTACACATGCGTGCCACCACACCTGGCTAATTTTTTTTTTTGTATTTTTAGT GGAGATGGGGTTTCACTATGTTGGCCAGGCTGGTCTCGAACTCCTGACTTTGTGATCTGC CTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGTCGTGAGCCACCGCACCCAGCCGCACC TACTCTTTTGTAAAGCACCTGTGACAATGAAGGACAGATTTATCACCTTGACGATTGTGG TGATGGGGACCTGATCCCAGCAGTCACAGGTCACAGGGGAAGGTCCCTGCTGAAGACAGA CCTCAGAAGGGCAGTTGATCCAGGACCCACACCTGCTTTCTTCACGTTTCCTGATCCTGC CCTGGGTCTGCAGTCACAGTTCAGGAAACTTCTCTGGGATCCAAAACTAGGAGGTTCCTC TAGGACCTTATGGCCCTGCCTCCTCCCTGGCCCCTCACAGGACATTTTCTTCCAACAGGT GGAAAAGGAGGGAGCTACTCTAAGGCTGAGTGTAAGTGCGGGGCGGGAGCGTGGAGGAGC TCGCCCACCCTATAATTCCTCCTGCACCACATCTCCTGTGGGCTCTGACCAGGTCTTGTT TTTGTTCTACCCCAGGGAGCGACAGTGCCCAGGGGTCTGAGTCTCACAGCTTGTAAAGGT GAGATTCTGGGGGTCTGAAGTGGGTGGAGGGTGGGGCAGAGGGGACAGGACTGGGTTGTG GGGATTTTTTGATTCAGAATTTTTGAGTGTGTGGTGGGCTGTTCAGAGTGTCATCACTTA CCGTGACTGACCTGAATTTGTTCATGACTATTTTCTTCTGTAGCCTGAGACAGCTGCCTT GTGTGCGACTGAGATGCACAGCTGCCTTGTGTGCGACTGAGATGCAGGATTTCCTCACGC CTCCCCTATGTGTCTTAGGGGACTCTGGCTTCTCTTTTTGCAAGGGCCTCTGAATCTGTC TGTGTCCCTGTTAGCACAATGTGAGGAGGTAGAGAAACAGTCCACCTCTGTGTCTACCAT GACCCCCTTCCTCACACTGACCTGTGTTCCTTCCCTGTTCTCTTTTCTATTAAAAATAAG AACCTGGGCAGAGTGCGGCAGCTCATGCCTGTAATCCCAGCACTTAGGGAGGCCGAGGAG GGCAGATCACGAGGTCAGGAGATCGAAACCATCCTGGCTAACACGGTGAAACCCCGTCTC TACTAAAAAATACAAAAAATTAGCTGGGCGCAGAGGCACGGGCCTGTAGTCCCAGCTACT CAGGAGGCGGAGGCAGGAGAATGGCGTCAACCCGGGAGGCGGAGGTTGCAGTGAGCCAGG ATTGTGCGACTGCACTCCAGCCTGGGTGACAGGGTGAAACGCCATCTCAAAAAATAAAAA TTAAAAAATAAAAAAAGAACCTGGATCTCAATTTAATTTTTCATATTCTTGCAATGAAAT GGACTTGAGGAAGCTAAGATCATAGCTAGAAATACAGATAATTCCACAGCACATCTCTAG CAAATTTAGCCTATTCCTATTCTCTAGCCTATTCCTTACCACCTGTAATCTTGACCATAT ACCTTGGAGTTGAATATTGTTTTCATACTGCTGTGGTTTGAATGTTCCCTCCAACACTCA TGTTGAGACTTAATCCCTAATGTGGCAATACTGAAAGGTGGGGCCTTTGAGATGTGATTG GATCGTAAGGCTGTGCCTTCATTCATGGGTTAATGGATTAATGGGTTATCACAGGAATGG GACTGGTGGCTTTATAAGAAGAGGAAAAGAGAACTGAGCTAGCATGCCCAGCCCACAGAG AGCCTCCACTAGAGTGATGCTAAGTGGAAATGTGAGGTGCAGCTGCCACAGAGGGCCCCC ACCAGGGAAATGTCTAGTGTCTAGTGGATCCAGGCCACAGGAGAGAGTGCCTTGTGGAGC GCTGGGAGCAGGACCTGACCACCACCAGGACCCCAGAACTGTGGAGTCAGTGGCAGCATG CAGCGCCCCCTTGGGAAAGCTTTAGGCACCAGCCTGCAACCCATTCGAGCAGCCACGTAG GCTGCACCCAGCAAAGCCACAGGCACGGGGCTACCTGAGGCCTTGGGGGCCCAATCCCTG CTCCAGTGTGTCCGTGAGGCAGCACACGAAGTCAAAAGAGATTATTCTCTTCCCACAGAT ACCTTTTCTCTCCCATGACCCTTTAACAGCATCTGCTTCATTCCCCTCACCTTCCCAGGC TGATCTGAGGTAAACTTTGAAGTAAAATAAAAGCTGTGTTTGAGCATCATTTGTATTTCA OMIM ID 143010