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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for HLA-F (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 3134 Official gene symbol HLA-F Full name major histocompatibility complex, class I, F Aliases ,CDA12,HLA-5.4,HLA-CDA12,HLAF, Gene summary This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. [provided by RefSeq] Location Chromosome: 6   Locus: 6p21.3 Gene position 29691117 - 29695073  Map Viewer Gene orientation plus Gene size 3957 bp Gene sequence >HLA-F:1207306..1211258:Length=3953 TTTCTCACTCCCATTGGGCGTCGCGTTTCTAGAGAAGCCAATCAGTGTCGCCGCAGTTCC CAGGTTCTAAAGTCCCACGCACCCCGCGGGACTCATATTTTTCCCAGACGCGGAGGTTGG GGTCATGGCGCCCCGAAGCCTCCTCCTGCTGCTCTCAGGGGCCCTGGCCCTGACCGATAC TTGGGCGGGTGAGTGCGGGGTCCAGAGAGAAACGGCCTCTGTGGGGAGGAGTGAGGGGCC CGCCCGGTGGGGGCGCAGGACTCAGGGAGCCGCGCCCGGAGGAGGGTCTGGCGGGTCTCA GCCCCTCCTCGCCCCCAGGCTCCCACTCCTTGAGGTATTTCAGCACCGCTGTGTCGCGGC CCGGCCGCGGGGAGCCCCGCTACATCGCCGTGGAGTACGTAGACGACACGCAATTCCTGC GGTTCGACAGCGACGCCGCGATTCCGAGGATGGAGCCGCGGGAGCCGTGGGTGGAGCAAG AGGGGCCGCAGTATTGGGAGTGGACCACAGGGTACGCCAAGGCCAACGCACAGACTGACC GAGTGGCCCTGAGGAACCTGCTCCGCCGCTACAACCAGAGCGAGGCTGGTGAGTGAACCC GGCCGGGGGCGCAGGTCACGACCACCCCCCATCCGCCACGGACCGCCCGGGTCCCTCAGA GTCTCCGGATCCGAAATCTACCCCGAGGCAGCGGGACCCGCCCAGACCCTCCACCCGGGA GAGTCCCAGGCGCCTTTACCCAGGTTCATTTTCAGTTTAGGCCAAAATCCCCGCGGGTTG GGCGGGGAGGGGGCGGGGCTAGCTGGGCGGGGCTGACTGCGGGGACCGGCTAGGGTCTCA CACCCTCCAGGGAATGAATGGCTGCGACATGGGGCCCGACGGACGCCTCCTCCGCGGGTA TCACCAGCACGCGTACGACGGCAAGGATTACATCTCCCTGAACGAGGACCTGCGCTCCTG GACCGCGGCGGACACCGTGGCTCAGATCACCCAGCGCTTCTATGAGGCAGAGGAATATGC AGAGGAGTTCAGGACCTACCTGGAGGGCGAGTGCCTGGAGTTGCTCCGCAGATACTTGGA GAATGGGAAGGAGACGCTACAGCGCGCAGGTACCAGGGGCCATGGGCGCCTTCCCTATCT CCTGTAGATCTCTTGGGATGGCCTCGCACAAGGTTGGGAGGAAAGTGGGCCCAATGCTAG GATATCGCCCTCCCTCTAGTCCTGAGTAGGAAGAATCTTCCTGGCTTTCGAGATCCGGTA CCAGAGAGTGACTGTGAGAGTCCGCCCTGCTCTCTGGGACAATTAAGGGATGAAATCTCT GAGGGAATGGAGGGAAGACAGTCCCTGGAATACCGATCCGCGGTCCCCTTTGAGCCCTCC AACAGCCTTGGGCCCCGTGACTTTTCTCTCAAGTTTTGTTCTCTGCCTCACACTCAATGT GTTTGGGGCTCTGATTCCAGTCCCTCGGCCTCCACTTAGGTCAGGGCCAGAAGTCCCTGC TCCCCCCTCAGAGACTCGAACTTTCCAAGGAATAGGAGATTTTCCCAGGTGTCTGTGTCC AGGCTGGTGTCTGGGTTCTGTGCTCCCTTCCCCACCCCAGGTGTCCTGTCCATTCTCAGG TTGGTCACATGGGTGCTGCTGGGGTTTCCCATGAGGAGTGCAAAGTGCCTGAATTTTCTG ACTCTTCTCAGATCCTCCAAAGGCACACGTTGCCCACCACCCCATCTCTGACCATGAGGC CACCCTGAGGTGCTGGGCCCTGGGCTTCTACCCTGCGGAGATCACGCTGACCTGGCAGCG GGATGGGGAGGAACAGACCCAGGACACAGAGCTTGTGGAGACCAGGCCTGCAGGGGATGG AACCTTCCAGAAGTGGGCCGCTGTGGTGGTGCCTTCTGGAGAGGAACAGAGATACACATG CCATGTGCAGCACGAGGGGCTGCCCCAGCCCCTCATCCTGAGATGGGGTAAGGAGGGAGA TGGGTAAAGAGGGGAACGAGGGGTCATGTCTTTTCTCAGGGAAAGCAGGAGCCCTTCTGG AGCTCTTCAGCAGGGTCAGGGCTGAGGCCTGGAGATCAGGGCCCCTCACCTTCCCTTCCT TTCCCAGAGCAGTCTCCCCAGCCCACCATCCCCATCGTGGGCATCGTTGCTGGCCTTGTT GTCCTTGGAGCTGTGGTCACTGGAGCTGTGGTCGCTGCTGTGATGTGGAGGAAGAAGAGC TCAGGTAGGAAGGGGTGAGGAGTGGAGTCTGAGTTTTCTTGTCCCACTGGGGGTTGCAAG CCCCAAGTAGAAGTGTGCCCTGCCTCATTACTGGGAAGCACCATCCACACTCATGGGTCT ACCCAGCCTGGGCCCTGTGTGCCAGCACCTACTCATTTGTAAAGCTCCTGTGAAAATGAA GGACAGATTCTTCACTTCGATGATTATGGTGGTGATGGGACCTGATCCCAGCAGTCACAA ATCACAGGGGAAGGTCCCTGCTGATGACAGACCTCAGGAGGGCAGTTGGTCCAGGACCCA CATCTGCTTTCTTCATATTTCTTGATCCTGCCCTGGATCTACAGTTACACTTTTCTGGAA ACTTCTCTGGGATCAAAGACTAGGGGTTTGCTCTAGGACCTTATGGCCCTGCCTCCTTTC TGGCCTCTCACAGGACATTTTCTTCCCATAGATAGAAACAGAGGGAGCTACTCTCAGGCT GCAGGTAAGATGAAGGAGGCTGATCCCTGAGATTGTTGGGATATTGTGGTCAGGAGCCTA TGAGGGAGCTCACCCACCCCACAGTTCCTCTAGCCACATCTGTGGGCTCTGACCAGGTCC TGTTTTTGTTCTACCCCAATCACTGACAGTGCTCAGGGCTCTGGGGTGTCTCTCACAGCT AATAAAGGTGACACTCCAGGGCAGGGGCCCTGATGTGAGTGGGGTGTTGGGGGGGAACAG AGGGGACTCAGCTGTGCTATTGGGTTTCTTTGACTTGGATGTCTTGAGCATGAAATGGGC TATTTAGAGTGTTACCTCTCACTGTGACTGATACGAATTTGTTCATGAATATTTTCTCTA TAGTGTGAGACAGCTTCCTTGTGTGGGACTGAGAAGCAAGATATCAATGTAGCAGAATTG CACTTGTGCCTCACGAACATACATAAATTTTAAAAATAAAGAATAAAAATATATCTTTTT ATAGATACAGGTAGATATGTTTTTATAGCATGCACGTAAATGTGTGTGTGTGTGTGTGTG AAGAGAAAGAGTGAATAGAGAGATTAAGATTCTTTTAATGGTGAAAAGATATACATATAT TTGGAATTAGCCAGCTTGACTCAGTTTAGGTGATCCCAATTTTGGTGGCAACAACCAAAG CATCGTAGTCAGGAGCCAGTCGAACATATGCCTTCCTCTCTCCATCAGACTGAATCAGAG TGTTGACTTTGGCCACATCAATGTCACAAACTTCTTCACAGCCTGTTTGATCTGGTGCTT GTTGGCTTTAACATCCACAGTGAACACAAGTAGGCTGTTGTTTTCTATCTTCTTCACAGC CTACTCAGTGGTCAGCGGAAACTTGATGATAACATGGTGGTCAAGCTTATTTCTCCTGGG GGTGCTCTTCCAAGGATATTTGGGCTGCCTCCGGAGTCACAGTGTCTTGGGCCGCCGGAA GGTGGGTGACATGTGGATCTTGTTTTTTTTGTGGCTGTGGACATCTTTCAACACTGCCTT CTTGGCCTTGCAAAGCCTTCGCTTTGGCTTCGGCTTTAGGAGGGGCAGGAGCTTCCTTCT TCGTTCTTGGCACCATCTTATGAAAAGGGTCCAGATTAAGATTTTTGACTGAGTCATTCT AAAGTAAGTTGCAAGACCCATGATACTAGACCACTAAATACTTCATCACACACCTCCTAA GAATAAGAACCAACATTATCACACCAAAGAAAATAAATAATTCCATAATATTA OMIM ID 143110