| Entrez gene ID | | 3176 |
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| Official gene symbol | | HNMT |
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| Full name | | histamine N-methyltransferase |
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| Aliases | | ,HMT,HNMT-S1,HNMT-S2, |
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| Gene summary | | In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq] |
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| Location | | Chromosome: 2 Locus: 2q22.1 |
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| Gene position | | 138721808 - 138773934 Map Viewer |
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| Gene orientation | | plus |
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| Gene size | | 52127 bp |
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| Gene sequence |
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| OMIM ID | | 605238 |
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