Entrez gene ID | | 321 |
Official gene symbol | | APBA2 |
Full name | | amyloid beta (A4) precursor protein-binding, family A, member 2 |
Aliases | | ,D15S1518E,HsT16821,LIN-10,MGC99508,MGC:14091,MINT2,X11L, |
Gene summary | | The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
Location | | Chromosome: 15 Locus: 15q11-q12 |
Gene position | | 29213840 - 29410518 Map Viewer |
Gene orientation | | plus |
Gene size | | 196679 bp |
Gene sequence |
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OMIM ID | | 602712 |
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