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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for APBB1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID322
Official gene symbolAPBB1
Full nameamyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
Aliases,FE65,MGC:9072,RIR,
Gene summaryThe protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants have been described for this gene but some of their full length sequence is not known. [provided by RefSeq]
LocationChromosome: 11   Locus: 11p15
Gene position6440644 - 6416355  Map Viewer
Gene orientationminus
Gene size24290 bp
Gene sequence
OMIM ID602709