Entrez gene ID | | 324 |
Official gene symbol | | APC |
Full name | | adenomatous polyposis coli |
Aliases | | ,BTPS2,DP2,DP2.5,DP3,GS, |
Gene summary | | This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq] |
Location | | Chromosome: 5 Locus: 5q21-q22 |
Gene position | | 112043218 - 112181936 Map Viewer |
Gene orientation | | plus |
Gene size | | 138719 bp |
Gene sequence |
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OMIM ID | | 611731 |
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