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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for APC (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID324
Official gene symbolAPC
Full nameadenomatous polyposis coli
Aliases,BTPS2,DP2,DP2.5,DP3,GS,
Gene summaryThis gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq]
LocationChromosome: 5   Locus: 5q21-q22
Gene position112043218 - 112181936  Map Viewer
Gene orientationplus
Gene size138719 bp
Gene sequence
OMIM ID611731