Home

Search

Browse

Statistics

User guide

FAQs

Links

Questions

Contribute

Download

Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for HP (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 3240 Official gene symbol HP Full name haptoglobin Aliases ,BP,HP2ALPHA2,HPA1S,MGC111141, Gene summary This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] Location Chromosome: 16   Locus: 16q22.1 Gene position 72088508 - 72094955  Map Viewer Gene orientation plus Gene size 6448 bp Gene sequence >HP:25702707..25709154:Length=6448 AGATGCCCCACAGCACTGCTCTTCCAGAGGCAAGACCAACCAAGATGAGGTGGGTCCACA GCTTTCCCTCCTGCCTTTCCTCTGGTTCTTTATTTCAGTCTTTTTTGCATACATCGGTAG AGATGCAGAAATAGAACAAAGAAACGGGCAAATGGGCTAAATTATAGTGAACCAAAGGGC TTAGTGTGTTAAATCTTCTCCTTTTCTGCATCCATAGAAGACAGTGCTGCTGTCTTTCCC AGGAGATAAGATTTACTCTCAGGAGTGTCTTTTTCCTTCAGGTTACATTTTTGACTTTAT AGGGTATGTCATCAGCTCCCGTGGTAGGCTTCCTGGCATCCTGAGTATATTTATTAGCAG ATATTTTCCTCTTTAAAAATGTACAATAAGGAAGACTAATAGTAACACATTTGAATGACA CAATTAATTGACTAGTACCTGGGATACACACTAATACCTGGGATACATCTAATTAAGGCA CTTAGATCTTATAAAAATAAACACTTTTTGAAATGTTGAAATAATAAGACTAGAAACTTT TTTTTTTTTTGAGATGGAGTCTCGCTTTGTCACCAGGCTGCAGTGCAGTGGCATGATCTC GGCTCACTGCAACCTCCACCTCCCAGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAGGT AGCTGGGACTACAGGCGTGCGCCACTATGCCCACCTAATTTTTGTATTTTTAGTAGAGAC GGGCTTTCACCATGTTGGCCAGGATGACCTCGATCTCTTGACCTCGTGATCTGCCTGCCT TGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGTGTCTGGCCTAGAAACTATT TTAATAGAAGCAAGTAGTGCCCGAATGGTTGGCATTTGTTAGTGAGATGGTGAACTGGCA GACGGCACCTGTGGGTCAATGCCCATGGCCACCGTCCTGCTTTTGGACACCAGTTCTCTT CCAGGTAACCTTCTGGCATTTTGGGGTTTCAGATACCATTTCCTAAAGGTGAATTATTAT AAAATACTAGAAATACCCACGTGTTTAAAATTATATATTTAAGGAACCTTTTATTACGGA AAATATCAAGAAGTAGAGGAATAGCACAGTAAGCCCAAAGTTCCCATCTCTGAGTTATCT ACATTTTATTACCACTATCTTTGCGGTGTCTGAGGGAGGTTTCTCTTTCCTGGAGGGCTC CTGTATTATTGCCAATGTACTTTCCTGAATGCAGCCAGAAACTGAGCCCACCCCTCCACC TATGTGCCTTTCTATCCCTCTCTGAAGCTTCTGCAGAATTCCCAGCAGGACAGGGCTTGC TGGAAGCTTGGTATGCTCAGAAGCTGCTAAAGTGTGTATGGGCAGGTGTGGGGGCAATTT CTTGGTCCTAGCACTTCCATATATCGACTTTCTTTTCTGGCTGCTAAGTGGGAGGAGTGT GTGTGTATGCATGTGTGTGTGTGTGTGTGTACATGCATGTGTGTGTGGATGCATGCATGT GCTGTGAAGCAGGGAGACTAGCTTTCCACTCCTCCTTGTCTTCTCTCTGCAGTGCCCTGG GAGCTGTCATTGCCCTCCTGCTCTGGGGACAGCTTTTTGCAGTGGACTCAGGCAATGATG TCACGGATATCGCAGGTCAGTCTTTGGTTGGGTAGGAGTGTGCATCCCACTCTGACCCTC TCGGGTCTGCACTCTCTCTGAGAACACCCAATTCCCCCTTCTTATCTCGACCTCTGGGCT TTCAGGACCATAAAGAACATTGGGGTTCCTGCCAGAAATGAGGGGAGCTTGCCTTTCCAT TGGCTTCTATTCGGGGTGGAAGGAGATTGATGTGCAGAGCAGCTCCCGCTCATCTGACTT TTCACGGTTCACTGGGAACAATTTCCAAATAGCAAACTCTCTGGCTTCTCTCTCTTTGCA GATGACGGCTGCCCGAAGCCCCCCGAGATTGCACATGGCTATGTGGAGCACTCGGTTCGC TACCAGTGTAAGAACTACTACAAACTGCGCACAGAAGGAGATGGTAAGATGTGGACAACT GTCTCCATGCCCTACATACAACCCCCTTCTCTGACATTTCCATGATGGGTGGTGCTGAGG TGATTCGCCAGAAAGTTCGTTGCTCTCCTTGGAGCCAGGAGATTTAGATTCTAATAAGCG TTTTGTCGCCAGTAGCCATGGCCCTTTGGGCAGACTAACTTTTGTCAGCCTCAAGTTTTC TGTTTTGTTAAGGGGAGGCGATGCCATGCAGCCTACCTCATGTAAATCTCAGAGTCACAT TTACATCTCCAGCAGATGTGGGAAAAGAAGGAATGCTGATGATGATGTCACCCTCACCTA GTGAGTCTTGCTGTCCTGGCACTGCTCTAAGGGCTTTATACTTATTTGCTCACTTAGTCC TCACAGTATCCCTCTGAACAGAGTTTATTGTTTTCACTTTGCTGATAAGGAAACTGAGGC ACAGACAGGTTGAGTATCTTGCCCAAATTCAGGCAGCCTGTAAGAGGCAGAGTCAGGATT TGAACCCTGAGCCCTCCCTGTACTGCTTGGCTGTGACCGCCATGACCACAGTGTGTTCTG CTGGGCTTAACTGGTGTCCAGGCACTTGGCTTCCAGCACAGCACTCTTTCCCTTCCTCCT TCTCATATTCTCTCTCCTTTCTCCCTTCCTGTCTGCCTCCTTTCTTCTTCTTCTTTTTAA TTCTTCTCCTTAAATGCCTTCTCACTCTGCTCTGGGTGCAGACTTGACTTTTCCTTTGGC TCATTTCTTGCCTTTTGTTTCAGGAGTATACACCTTAAATGATAAGAAGCAGTGGATAAA TAAGGCTGTTGGAGATAAACTTCCTGAATGTGAAGCAGGTGGGTGCTGAGCACTGAGCAC TTAAGAGAGCAGGCAGGCGTCCAGCGGGGAACGTCCTAGAGGCACAGCCTTCCAGTGCGG CTTCCTCTGAGCACACAAGAGCCAGGAGGAGGGATGTGGGAGAACCGCAGCTGGCCAGGG AGAGACTTAAGCAGTTAGGTGATGACTCCCTAAGGGTCACCAAGGGTCTTGTTCATTGGG GCCTGAAGGGCACTGGCTGAATCCACTGTCGGCACTGCCCACAGATCAGGAGAGCCTGTG CATACAGAGAGCCTGCTAGAAAGCCCTGGGTCTAAGGAGAAGCAAGCTCCAGGGAGAACA AGTCAAGGAATGACATAAAATCTTAATCCATGGAAGCCTAGCAGGAGGCTGGACATGGGC TGGAACTCCTGCTTCTCGTTATTAGGAGGAGCTGTTGCTCTCTCCTTTCATTCTCAGAAC CAGAGGCAAAGACCCAGCCTCTTCTGCTCTTACTGGTGTGGAAATGCCAACCTGCCTCGT ATTAACTGCACCATCTACAAAATCTGAGCTCCAGCCAGTGCTGCTCTAGATTCATCTTTC TTTAGAGAGAATGAATTATTGTAGCCCCTAGCCCTTTCAATGAATTTCAGGGAATTGTGG AAATTCCTTTATTGGGATAATTGTTTAAAAATAATACAGTTCGCGAGCTTCTATTCGGGG TGGAAGGAGATTGATGTGCAGAGCAGCTCCCGCTCATCTGACTTTTCACGGTTCACTGGG AACAATTTCCAAATAGCAAACTCTCTGGCTTCTCTCTCTTTGCAGATGACGGCTGCCCGA AGCCCCCCGAGATTGCACATGGCTATGTGGAGCACTCGGTTCGCTACCAGTGTAAGAACT ACTACAAACTGCGCACAGAAGGAGATGGTAAGATGTGGACAACTGTCTCCATGCCCTACA TACAACCCCCTTCTCTGACATTTCCATGATGGGTGGTGCTGAGGTGATTCGCCAGAAAGT TCGTTGCTCTCCTTGGAGCCAGGAGATTTAGATTCTAATAAGCGTTTTGTCGCCAGTAGC CATGGCCCTTTGGGCAGACTAACTTTTGTCAGCCTCAAGTTTTCTGTTTTGTTAAGGGGA GGCGATGCCATGCAGCCTACCTCATGTAAATCTCAGAGTCACATTTACATCTCCAGCAGA TGTGGGAAAAGAAGGAATGCTGATGATGATGTCACCCTCACCTAGTGAGTCTTGCTGTCC TGGCACTGCTCTAAGGGCTTTATACTTATTTGCTCACTTAGTCCTCACAGTATCCCTCTG AACAGAGTTTATTGTTTTCACTTTGCTGATAAGGAAACTGAGGCACAGACAGGTTGAGTA TCTTGCCCAAATTCAGGCAGCCTGTAAGAGGCAGAGTCAGGATTTGAACCCTGAGCCCTC CCTGTACTGCTTGGCTGTGACCGCCATGACCACAGTGTGTTCTGCTGGGCTTAACTGGCA TCCAGGCACTTGGCTTCCAGCACAGCACTCTTTCCCTTCCTCCTTCTCATATACTCTCTC CTTTTCCCCTTCCTTTTTGTCCCCTTTTCCTCTTCCTTTTAGTTCTTCTCTTTAAATGCC TTCTCACTCTGCACGGGGTCTAGACTTGACTTCTCCTTTGGCTCACTTCTTGCCTTTTGT TTCAGGAGTGTACACCTTAAACAATGAGAAGCAGTGGATAAATAAGGCTGTTGGAGATAA ACTTCCTGAATGTGAAGCAGGTGGGTGCTGAGCACTTAAGAGAGCAGGCAGGCGTCCAGC GGGGAACGTCCTAGAGGCACAGCCTTCCAGTGCGGCTTCCTCTGAGCACACAAGAGCCAG GAGGAGGGATGTGGGAGAACCGCAGCTGGCCAGGGAGAGACTTAAGCAGTTAGGTGATGA CTCCCTAAGGGTCACCAAGGGTCTTGTTCATTAGGGCCTGAAGGGCACTGGCTGAATCCA TTGTCTACATCGCCCACAGATTAGGAGAGCCTGTGCATACAGAGAGCCTGCTAGAGAGCC CTGGGTCTAAGGAGAAGCAAGCTCCAGGGAGAACAAGTCAAGGAATGACATAAAATCTTA ATCCATGGAAGCCTAGCAGGAGGCTGGACATGGGCTGGAACTCCTGCTTCTCGTTATTAG GAGGAGCTGTTGCTCTCTCCTTTCATTCTCAGAACAAGAGGCAAAGGCCCAGCCTCTTCT GCTCTTACTGGTGTGGAAATGCCAACCTGCCTCGTATTAACTGCACCATCTACAAAATCT GAGCTCCAGCCAGTGCTGCTCTAGATTCATCTTTCTTTAGAGAGAATGAATTATTGTAGC CCCTAGCCCTTTCAATGAATTTCAGGGAATTGTGGAAATTCCTTTATTGGGATAATTGTT TAAATATAATACAGTTCACCAGCCAGGGCTCAAAAATCTCAGTATTTCCCACTTCCTTTG TTAGAAAAGTGGGAAATAGAGCTTTTTGTAATGTAAACAATTTAAAAAACAGAATTATTT TAAAACTGCAACTATTGGAAATGAGATCAGCAGGTGGTAAGGGCAAAGCATTTAAATCTT TCTACTTTACGCAGCAGTGACAGCCGCCCATGCTTTCACCCCTTTCTCAGATGGAAAGGC TCTTGCACATTTCCACTCACGAGTGTCTTGCTCTCCTTGACAGTATGTGGGAAGCCCAAG AATCCGGCAAACCCAGTGCAGCGGATCCTGGGTGGACACCTGGATGCCAAAGGCAGCTTT CCCTGGCAGGCTAAGATGGTTTCCCACCATAATCTCACCACAGGTGCCACGCTGATCAAT GAACAATGGCTGCTGACCACGGCTAAAAATCTCTTCCTGAACCATTCAGAAAATGCAACA GCGAAAGACATTGCCCCTACTTTAACACTCTATGTGGGGAAAAAGCAGCTTGTAGAGATT GAGAAGGTTGTTCTACACCCTAACTACTCCCAGGTAGATATTGGGCTCATCAAACTCAAA CAGAAGGTGTCTGTTAATGAGAGAGTGATGCCCATCTGCCTACCTTCAAAGGATTATGCA GAAGTAGGGCGTGTGGGTTATGTTTCTGGCTGGGGGCGAAATGCCAATTTTAAATTTACT GACCATCTGAAGTATGTCATGCTGCCTGTGGCTGACCAAGACCAATGCATAAGGCATTAT GAAGGCAGCACAGTCCCCGAAAAGAAGACACCGAAGAGCCCTGTAGGGGTGCAGCCCATA CTGAATGAACACACCTTCTGTGCTGGCATGTCTAAGTACCAAGAAGACACCTGCTATGGC GATGCGGGCAGTGCCTTTGCCGTTCACGACCTGGAGGAGGACACCTGGTATGCGACTGGG ATCTTAAGCTTTGATAAGAGCTGTGCTGTGGCTGAGTATGGTGTGTATGTGAAGGTGACT TCCATCCAGGACTGGGTTCAGAAGACCATAGCTGAGAACTAATGCAAGGCTGGCCGGAAG CCCTTGCCTGAAAGCAAGATTTCAGCCTGGAAGAGGGCAAAGTGGACGGGAGTGGACAGG AGTGGATGCGATAAGATGTGGTTTGAAGCTGATGGGTGCCAGCCCTGCATTGCTGAGTCA ATCAATAAAGAGCTTTCTTTTGACCCAT OMIM ID 140100