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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for HRAS (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 3265 Official gene symbol HRAS Full name v-Ha-ras Harvey rat sarcoma viral oncogene homolog Aliases ,C-BAS/HAS,C-H-RAS,C-HA-RAS1,CTLO,H-RASIDX,HAMSV,HRAS1,K-RAS,N-RAS,RASH1, Gene summary This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq] Location Chromosome: 11   Locus: 11p15.5 Gene position 535550 - 532242  Map Viewer Gene orientation minus Gene size 3309 bp Gene sequence >HRAS:complement(472242..475550):Length=3309 TGCCCTGCGCCCGCAACCCGAGCCGCACCCGCCGCGGACGGAGCCCATGCGCGGGGCGAA CCGCGCGCCCCCGCCCCCGCCCCGCCCCGGCCTCGGCCCCGGCCCTGGCCCCGGGGGCAG TCGCGCCTGTGAACGGTGAGTGCGGGCAGGGATCGGCCGGGCCGCGCGCCCTCCTCGCCC CCAGGCGGCAGCAATACGCGCGGCGCGGGCCGGGGGCGCGGGGCCGGCGGGCGTAAGCGG CGGCGGCGGCGGCGGCGGCGGGTGGGTGGGGCCGGGCGGGGCCCGCGGGCACAGGTGAGC GGGCGTCGGGGGCTGCGGCGGGCGGGGGCCCCTTCCTCCCTGGGGCCTGCGGGAATCCGG GCCCCACCCGTGGCCTCGCGCTGGGCACGGTCCCCACGCCGGCGTACCCGGGAGCCTCGG GCCCGGCGCCCTCACACCCGGGGGCGTCTGGGAGGAGGCGGCCGCGGCCACGGCACGCCC GGGCACCCCCGATTCAGCATCACAGGTCGCGGACCAGGCCGGGGGCCTCAGCCCCAGTGC CTTTTCCCTCTCCGGGTCTCCCGCGCCGCTTCTCGGCCCCTTCCTGTCGCTCAGTCCCTG CTTCCCAGGAGCTCCTCTGTCTTCTCCAGCTTTCTGTGGCTGAAAGATGCCCCCGGTTCC CCGCCGGGGGTGCGGGGCGCTGCCCGGGTCTGCCCTCCCCTCGGCGGCGCCTAGTACGCA GTAGGCGCTCAGCAAATACTTGTCGGAGGCACCAGCGCCGCGGGGCCTGCAGGCTGGCAC TAGCCTGCCCGGGCACGCCGTGGCGCGCTCCGCCGTGGCCAGACCTGTTCTGGAGGACGG TAACCTCAGCCCTCGGGCGCCTCCCTTTAGCCTTTCTGCCGACCCAGCAGCTTCTAATTT GGGTGCGTGGTTGAGAGCGCTCAGCTGTCAGCCCTGCCTTTGAGGGCTGGGTCCCTTTTC CCATCACTGGGTCATTAAGAGCAAGTGGGGGCGAGGCGACAGCCCTCCCGCACGCTGGGT TGCAGCTGCACAGGTAGGCACGCTGCAGTCCTTGCTGCCTGGCGTTGGGGCCCAGGGACC GCTGTGGGTTTGCCCTTCAGATGGCCCTGCCAGCAGCTGCCCTGTGGGGCCTGGGGCTGG GCCTGGGCCTGGCTGAGCAGGGCCCTCCTTGGCAGGTGGGGCAGGAGACCCTGTAGGAGG ACCCCGGGCCGCAGGCCCCTGAGGAGCGATGACGGAATATAAGCTGGTGGTGGTGGGCGC CGGCGGTGTGGGCAAGAGTGCGCTGACCATCCAGCTGATCCAGAACCATTTTGTGGACGA ATACGACCCCACTATAGAGGTGAGCCTGGCGCCGCCGTCCAGGTGCCAGCAGCTGCTGCG GGCGAGCCCAGGACACAGCCAGGATAGGGCTGGCTGCAGCCCCTGGTCCCCTGCATGGTG CTGTGGCCCTGTCTCCTGCTTCCTCTAGAGGAGGGGAGTCCCTCGTCTCAGCACCCCAGG AGAGGAGGGGGCATGAGGGGCATGAGAGGTACCAGGGAGAGGCTGGCTGTGTGAACTCCC CCCACGGAAGGTCCTGAGGGGGTCCCTGAGCCCTGTCCTCCTGCAGGATTCCTACCGGAA GCAGGTGGTCATTGATGGGGAGACGTGCCTGTTGGACATCCTGGATACCGCCGGCCAGGA GGAGTACAGCGCCATGCGGGACCAGTACATGCGCACCGGGGAGGGCTTCCTGTGTGTGTT TGCCATCAACAACACCAAGTCTTTTGAGGACATCCACCAGTACAGGTGAACCCCGTGAGG CTGGCCCGGGAGCCCACGCCGCACAGGTGGGGCCAGGCCGGCTGCGTCCAGGCAGGGGCC TCCTGTCCTCTCTGCGCATGTCCTGGATGCCGCTGCGCCTGCAGCCCCCGTAGCCAGCTC TCGCTTTCCACCTCTCAGGGAGCAGATCAAACGGGTGAAGGACTCGGATGACGTGCCCAT GGTGCTGGTGGGGAACAAGTGTGACCTGGCTGCACGCACTGTGGAATCTCGGCAGGCTCA GGACCTCGCCCGAAGCTACGGCATCCCCTACATCGAGACCTCGGCCAAGACCCGGCAGGT GAGGCAGCTCTCCACCCCACAGCTAGCCAGGGACCCGCCCCGCCCCGCCCCAGCCAGGGA GCAGCACTCACTGACCCTCTCCCTTGACACAGGGCAGCCGCTCTGGCTCTAGCTCCAGCT CCGGGACCCTCTGGGACCCCCCGGGACCCATGTGACCCAGCGGCCCCTCGCGCTGTAAGT CTCCCGGGACGGCAGGGCAGTGAGGGAGGCGAGGGCCGGGGTCTGGGCTCACGCCCTGCA GTCCTGGGCCGACACAGCTCCGGGGAAGGCGGAGGTCCTTGGGGAGAGCTGCCCTGAGCC AGGCCGGAGCGGTGACCCTGGGGCCCGGCCCCTCTTGTCCCCAGAGTGTCCCACGGGCAC CTGTTGGTTCTGAGTCTTAGTGGGGCTACTGGGGACACGGGCCGTAGCTGAGTCGAGAGC TGGGTGCAGGGTGGTCAAACCCTGGCCAGACCTGGAGTTCAGGAGGGCCCCGGGCCACCC TGACCTTTGAGGGGCTGCTGTAGCATGATGCGGGTGGCCCTGGGCACTTCGAGATGGCCA GAGTCCAGCTTCCCGTGTGTGTGGTGGGCCTGGGGAAGTGGCTGGTGGAGTCGGGAGCTT CGGGCCAGGCAAGGCTTGATCCCACAGCAGGGAGCCCCTCACCCAGGCAGGCGGCCACAG GCCGGTCCCTCCTGATCCCATCCCTCCTTTCCCAGGGAGTGGAGGATGCCTTCTACACGT TGGTGCGTGAGATCCGGCAGCACAAGCTGCGGAAGCTGAACCCTCCTGATGAGAGTGGCC CCGGCTGCATGAGCTGCAAGTGTGTGCTCTCCTGACGCAGGTGAGGGGGACTCCCAGGGC GGCCGCCACGCCCACCGGATGACCCCGGCTCCCCGCCCCTGCCGGTCTCCTGGCCTGCGG TCAGCAGCCTCCCTTGTGCCCCGCCCAGCACAAGCTCAGGACATGGAGGTGCCGGATGCA GGAAGGAGGTGCAGACGGAAGGAGGAGGAAGGAAGGACGGAAGCAAGGAAGGAAGGAAGG GCTGCTGGAGCCCAGTCACCCCGGGACCGTGGGCCGAGGTGACTGCAGACCCTCCCAGGG AGGCTGTGCACAGACTGTCTTGAACATCCCAAATGCCACCGGAACCCCAGCCCTTAGCTC CCCTCCCAGGCCTCTGTGGGCCCTTGTCGGGCACAGATGGGATCACAGTAAATTATTGGA TGGTCTTGA OMIM ID 190020