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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for APEH (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 327 Official gene symbol APEH Full name N-acylaminoacyl-peptide hydrolase Aliases ,ACPH,APH,D3F15S2,D3S48E,DNF15S2,MGC2178,OPH, Gene summary This gene encodes the enzyme acylpeptide hydrolase, which catalyzes the hydrolysis of the terminal acetylated amino acid preferentially from small acetylated peptides. The acetyl amino acid formed by this hydrolase is further processed to acetate and a free amino acid by an aminoacylase. This gene is located within the same region of chromosome 3 (3p21) as the aminoacylase gene, and deletions at this locus are also associated with a decrease in aminoacylase activity. The acylpeptide hydrolase is a homotetrameric protein of 300 kDa with each subunit consisting of 732 amino acid residues. It can play an important role in destroying oxidatively damaged proteins in living cells. Deletions of this gene locus are found in various types of carcinomas, including small cell lung carcinoma and renal cell carcinoma. [provided by RefSeq] Location Chromosome: 3   Locus: 3p21.31 Gene position 49711435 - 49720934  Map Viewer Gene orientation plus Gene size 9500 bp Gene sequence >APEH:49651435..49660934:Length=9500 CTCAACCCCTTCTCTCGTAGGCCCTTCTACCCTCCCCGAAGCCGGGCTCCCGGGTTCCGC TTCCACAGGGCCGCCCCCTCTCCTCCGAGATCCAACGCCTCGCCCCTCGGTAAGAGGCCC AGGACTCAGCCCACGGCCCCGCCCCCCACTTGGCTAGTCCGCCCCTGGCGAGACCCCTGC TCTCACCCACCCAGGACTTCTCGCTCCCAGGCCGGGTCCTCTCACCGTCAAGGCCCGCCC CCTGCCAACGGTCCTCACCCATTAGCCGAAGGCCCCGCCCCTCACAGATTGCCGCAGGGC AGGGGCGGAGACAGCCCGGGCCGTCCCAGGCTCCGCCCCCGGAAGCCTCACTTCCGGGCG CGAGCACGCCCCGCCTCGCCCCGGCGGCAGAGAGGAGACTATGGAACGTCAGGTGAGGGC TCGGCCCGCGGTCCCCGTGGTCCCTGCAGCCCGGGCCGGGCCTGACCCTGGTGTGTCCCC TGCGCAGGTGCTGCTGAGCGAGCCCGAGGAGGCGGCGGCTCTGTATCGGGGCCTTAGCCG CCAGCCCGCGCTGAGCGCCGCCTGCCTGGGCCCGGAGGTCACCACGCAGTACGGCGGCCA ATACCGGACGGTGCACACTGGTGTGTGTGCGAAGGGGAACTGGCTGGCGACGGGGTCGCG CACTGGGGTGGGAAGGAAGGGGGTGTGGAGGGCTCGCTGCTTGACAGTGCGTAAGGGTAT ATAGGGAGCCGGCCTGGACTTGGAGGTTACACTCCCACAGGTCCCTGCACACAGGTGTGT GGAGGGGGGGAGGGGGCGTGCGGGGCGTTATCGAATGGCGGCCATGAGTGCACGAGATGA CGGCGTAGGGGTAGAAGTCAAACCTGGGCTCAGGGCGTGGACCTTGTAGGGCTCTCCACC AACACGCCATCCCATACACATGCCAGGCTGCCCTCAAGATTCCAGGGTGGATGCTGGGGT TACTAGGGGGTTCTCTCAAAGAGGCTGTCAGCTCAGGCTCTGGAGGCCTGGACTAGGGTT GTGGCCAAGTGTTGTCCAGCCTGCAGCCAGGGTGTCAGTGTCTGGAGACAGATTGAGAGA TTGGGGAAGATAGATCTAGGCCTTCCTGGGTCAGGTGGGGCTGGGGGCAGTAGCCAGGAG TAGCCAAGACAAGGTGAGCAGTCTCATGCCTCCCCTCACAGAGTGGACCCAGAGGGACCT GGAACGCATGGAGAACATTCGATTCTGCCGCCAATACCTGGTGTTCCATGACGGGGACTC AGTGGTGTTTGCAGGACCTGCAGGCAACAGTGTGGAGACCCGGGGGGAGTAAGTTTGAGG GAGGAAGCTTGTGGGCAAGGCCACAGCCGTCCGCAATGCAAGCCTTTTATGAATGCTCAC CATGTGCCTAGAAGGGAGGCCAGCAGCCAGGTTCTTGCCCCCTTGGGAGCTCATTCAGTT TCTGGTGACATGGCCTGATAAGCACTGGAAGCTTGCTCCAAACTCAGCCTGGACTAGAGC CCATGGTGGCCTGGGGAGTTGCAGAGAGTAGAGTCTCTGCCTCAGGGAGGAAAGGCAAGG TGGGGCTAGAGGTGCTCCAGAAGCTGGTGTGGGGCCAGAGCCTCAAGAATCTCTCCTAAG AGGTGTGCCCAGTAGGGAGCAGGAAGGGGTTATTGCAAGATAATCCTGACCTGTGCTACC CCATGTCCACAGACTGCTGAGCAGAGAGTCTCCTTCAGGCACCATGAAAGCTGTGCTGCG CAAGGCTGGAGGCACGGGCCCTGGGGAAGAGAAGCAGTTCCTGGAGGTGAGTCTGCATGG GACCAGGTAGTGGGTGACAAGAGAGAGGCTCTGCCCCACAGATAAGGCTCTGTTAGCGGG CAAACAGCCTAATGCCCAGATGTCCTCAGGTCTGGGAGAAGAACCGGAAGCTCAAGAGCT TCAACCTGTCAGCGCTGGAGAAACATGGGCCTGTTTATGAGGATGGTGAGGCATCTGGCT GGTGAGCAGGCAGGGTGGACAGGAGGGGTAGCCGTAGCCCTGGGCCCCCCCTGATTGGCC CTCCCTGCACCCAGACTGCTTTGGCTGCCTGTCCTGGTCGCACTCGGAGACACACTTGTT GTATGTGGCAGAGAAGAAGCGCCCCAAGGCCGAGTCCTTCTTTCAGACCAAAGCCTTGGA CGTCAGTGCCAGCGATGATGAGATAGCCAGGCTGAAGAAGCCAGACCAAGCCATCAAGGT GCTCGTGGTCAATCCACGAAGGCCCGGCAGGGCAGCCCTGGGGCTCAGTGTGCTCCCTTC CCATACTGTGCCTGTCAGACCTGGGGAGGCACTAGCTTTTAGGAAGCAGAGCAGGTCCTA TAGACAGGCTGGGCATTGAGTATCTTGTGTTCTCAGGGGGATCAGTTTGTGTTTTATGAA GACTGGGGAGAAAACATGGTTTCCAAAAGCATCCCTGTGCTCTGCGTGCTGGATGTCGAG AGTGGCAACATCTCTGTGCTTGAGGGGGTCCCTGAGAATGTGTCCCCTGGACAGGTCAGC AGCAACAGCCTGTGTCCCCCCTGGAGTCTGGGACCCTTCTTGAGCTACCACCCCTTGCTC ACTCCTGCCCTTTGATCCTGTTTACAGGCATTTTGGGCCCCTGGAGATGCTGGTGTGGTG TTTGTGGGCTGGTGGCATGAGCCCTTCCGGTTGGGCATCCGCTTTTGCACCAATCGCAGG TGAGGGAGTGGGGCAAGGCAAGGGGCCTTGCAGCCCAGCTGGCCTTGAGACTGAGTGTCT GTCTCGTGGTTCCAGGTCAGCCCTGTATTATGTGGACCTCATCGGGGGGAAGTGTGGTAA GTGGCTGATGCCCACCTGTGCTTTGCTGACACATGTTGGCCCTGCCAGCCTGCGTGATGC TCATGTTTCCATCTGGCCCAGAGCTCCTCTCGGATGACTCCCTGGCTGTCTCTTCTCCCC GGCTGAGCCCAGACCAATGTCGCATTGTCTACCTGCAGTACCCATCTCTGATCCCCCATC ACCAATGCAGCCAGCTGTGCCTGGTGAGCTGGAGGTGGCAGGGATGGGAGGGTGGTCAGC AAGAAGATGGGATGGTGGATGAGAGCTGAAGGGCCAGTATCATCTCCCCATAGGCCCTCA GTAGGTGCCCTTCTGTCCTCAATGCAGCAGCGGTGTGAGTTCTGCCTGTCCTCTCAAGGA GGGCCTAGAGGTTGAGAGTGCTGCCATGGAGAGCTTTGCACTGTTGGGGCATTCCACCTT GAGAGAATGCTCGTCTGCAAGAATGCTCCTCCCCTTGGCTCTCAACTGCATGTAGCCAGG CTCTGCAAGGGGCTGGGATATAGTGGGGAGTTACACAATCCCAGACCCTCCCCAGGAAGA GCTCTGGGCCCCTGGTAAAAGTCAGAGGGACATGCCTATCTGAGGCCCCTTGGGCATCTG GTCCAGGTCACCAGAAAAGAGATACATCAGGCTTATTCCAGTTCCCCCATCTCCTGGGGC TACCTGAGGCAAAAGGGGATAGGCACAGGGCACTGTGCCCTAAGGGAACTGCCTGTCCCC TACTGGACCTGACCATTGTGTTCTCTTGCAGTATGACTGGTATACCAAGGTTACCTCAGT GGTGGTAGATGTTGTGCCTCGGCAGCTGGGAGGTAAGGCATACCTGGCTGGGTGGGTGCA GTGGGGCCTGTAGCTCTGCTTTCCTGCCGTCTGTTGCATCCCTGCCCCGTTCTTCTTTCC TAGGTTCCTTCTGAGGGCCCTACCTCCCTGCTGGGCCAGCCTTATGCCCAGCATCCTCAG GGAGCGGGGCTGTCACCATAGGGAGCGGGGCTGTCACCGTAGGGAACAGTTCAATAGCAA GGAGTGGTAGGACCAAGCTGAGATCAGAGTGGCCCAAGTTGATGATGTATTATTTCCTGT GCTGCAGGTCATAATTAGAGTTTTCTTATTTTTCCAATGGCTGGTTCAAACCAAAACCAT GACTCCTTCAAGTGGGTCTCAGGAAGTGCACTAGGTTGGAATGTCACACTCGAGAGGCTC TGGACCCGAGGGCATGATATTATCCCATCCACCATCCTAACCCCAGCAACCTTTGTCCAG TCTAAGCCCTGAAGTCAGCTGGGTCTTCAGGAGGGTGGCTCTTGGCTGAGAGGCTCCCGT CTCGAGTGTTGATAGCTCTGCTTGGATCCTCCTGGACCATCTCAAGGATGAGTCTCTTGT TTTCTCAGGCCACCCGGTCAGTTCCAGGAGTTCAGTGGACAAGGGATAGCCTCTTTGTCT TCTCTTTGGGTTGCAGGGATGCAGTGGTGGGAACCTAGTATGAATCCCAGCTCTGCCCTA AATTAGCTGTGTCCTCAGACAGGGTCCTGGCCTCCCTGAGCTCCCATTTCTTCATGGAGG GGTGATTGTGTCTGCCTGCCTCATAGGATCATAGTGAGTGTTAAGTGAGTGATGATATTA AAGGGTAGGATTTACTGAGCCCCCTGTGCCAAGCGCTGTGCTAAGCACCACAGTGGAGAT AAGACGGACAGATGATATCTTGGTTAAAGCACCTGGTACCTACCTGGGTTCAACTGGAAT TACTCAGGAGAGCAAGTGCTTTTCCTCTGAGCACCCATGGTTTCTCTCTGGAGCTCTTGA GCTCTGCCTCTCTGGGTCCTCTCTGGGTCCCAAGAGGCCTCTGCCCCTCAGCCACCTACT CAGGCAGCTCCTCATCGCGTAGCGTGCCCCCATGTGTGCTACAAGCTGCAGGGGCCTGAC TGGTGCCTGAGTAGGGCCCTGGGTGAATTCCCCAGTACCCTAGCCTTCCTTGTAGACTAC CCTCCCTACCTCCACTCCTGGATGCAGCCTCAGCCCTCCTATCTTTACAGAGAACTTCTC TGGGATCTACTGCAGCCTTCTGCCTTTGGGATGCTGGTCAGCTGACAGCCAGAGAGTGGT CTTTGACTCGGCTCAGCGCAGCCGGCAGGTGAGGGACGCTGATTGTGTTGAGGGGCAGCC CCTGTGGTCAACCCCCAGGAGCCCTGGGGGTTGCATGTGCATGCCCCTGGGTGGAATGCC CAGCCACAAAGTCTCATCAGCCCCTTAAAACCCTGCCTGCCCATCCTGGACTCATTTCTC CTGGAGGGGACTGGCTGCCCTGGTGCACCACAGCAGAACTCAGGCCTTTTCGTCTGAGGC AGAGATGCAACCCCTCCCAGGCATTTCTAGCTGGGGGTCAAGGGGACTGCCACTCGGGTG GGTCCCTGAACACTCTGTAATGGCAGCTGATGGGGACAGGACTGAGGCCTTCCCCCAGGG ATGGAGTAAAGCCACTCACAGTGTGCCAGGCTCCTTTTGGGTGTGATATTTGGTCCTTGT GCCAACTCAAAGGGGCTCAAAGCCATTCCTTACCTTGCCCAGGGTCACCCAGCAAGTTGT GATGGTGCTGGGATTTGAACCCAGGCCCTCACACTACTCCCTACTGCACTGAGTAACCAT CACCATAGCTGTCCACAGCCTTGGTCTGGCCAGGGCTCTCCAAGAGGGTAGAGAGGAGGT AGGGGAGGGACCCATAGGTAGAGGGAGTACTCTTGGATGTGGTCGCACCTGTGGCCTTGC CTCTGCTTCAGGACCTGTTTGCTGTGGACACCCAAGTGGGCACTGTGACCTCCCTCACAG CTGGTGAGCAAGGCTTTGGGGATGGGGGTAAGGGCAGGGCTGGTGAGCAAGCCAACCAGG CAGCGGGGGACTGGAGCTCCAACATGTGGGGCAGTGATGGCATTCTCAGCCACTCAGCAC CACTGACTGTTCCACAGCCTTTACTAACAGGTCCCCAAGGCCCCTGTCTGTGCAGACCCT TACCCAACCAACAGACTAGCTTCCCTGCTCTACTGCCCTTTAGCACTCAACTCTGTTCCA TGTGTCCTGGCCCAGCCTCAGCACGGCCCCCACCTCTGCTCCTAAAACCCACAAAACTCT CTCTTATCAAGATCTGCCAGACTCATCCTTCTCGCTCTGCAAACCTTGGGTGCCTGTCTC AGGCAGAGGCAGCTCTGCCACCTGAGGGCCCAGGAAAAGCCCAGTGTTGACTCCCCCGTC TTCCCCATACTTAGGCCTGGTGATTCTGCCTTTGAAATGTGTTTTGAGTCCTCCACCTGA CCTGACTGTATCCGCTCCTCCACAAAGCTACCAAAGTATCATTCCAAAGCTACATCTCAT TGTACAACTGCTTGGACACCACTGCCCCAAATCAGCACGCTCCCCGACCCCCAACTTCCC GGTCCCAGCTGCCACCCTGCACACAGCAGCCATCGAGGGACAGGCAGATGTGCCTGCATG GTCTGATGTGTCTTAAGGTTTGGCAGTTCCCAGCCCAGCCAGTGTCTGTCAGATGAACAA CAGACTGAGAGCAGGAGGCTCACCCGGGGCCATGTGCAGTTGGGTGTTTGTGAAAGGCAC TTCTCGGGGAGAAAAGGGCACCTTTCCATAGAGTCTCCAGCCTGGGACTCTGTTACAGAG AAGCAGGTAAGAAAGGTGATGGCTCCTGCTAAGCACTTAATGGCATCTGCCTTTTCCAGG AGGGTCAGGTGGGAGCTGGAAGTTGCTCACAATTGACCAGGACCTCATGGTGGCACAGTT TTCCACACCCAGCCTACCTCCAACCCTGGTGAGTGTCGGTGGGTCCCAGGCTGTGGAGGC AGGGGTTCTGGGCAGGCAGAGCTCACCAGGTCAGGGAATTGGCCCCAGAGTCTGACCTGG CTGGTCAGCATACAGACGGGCCAAGACACAGGCCCAGCTTGGCATGGTCCATGAGGGTTT GGCACTCACAGGGACGAACTACTAGGCTAGAATCTGCTCCGTACAAAACAAGGTGCCTGG GGAAGTGCTCTGTCTTGGTATTACAGAGCAAAGGAGACAGCAGAGCCTAGAAGCTGAGGA GGGAGGGGTGTGCCTGTGTGTGATTGTATGAGTATGAATACCTTGGTATATACCATCCCA CAACAGGAAGCCATGCTGTACCTTCTGGAGGTGGGTAGAGGGCCCAGCATAGTGAGAGCT GCCTATTTCCCACTGTGGGCAGAAGGGAAGGGCAGGGAGGCAGCCAGGCCACCTATGACA CATTCTTTCCCCTTGGCAGAAAGTTGGGTTCCTGCCTTCTGCAGGGAAGGAGCAGTCAGT GTTGTGGGTGTCCCTGGAGGAGGCCGAGCCCATTCCCGACATCCACTGGGGCATCCGGGT GCTACAGCCACCCCCAGAGCAAGAGAATGTGCAGTATGGTGAGCTGGGCCAGGGGCAGAG GGATGCCTTCTCCAGGTTCCCCAGCACAAAGCCTCTGCGGTGACCTTTGCTACCTCCTCT CTCACATTGTGGGGTTTCTGGTGATGACCTCTAAGAGGTTTTCTGTTCCTCTTGTGGATG GGCATGGGAAGTAGCATCTAGACATCTGAGCGCCTGCTCTGGATATCACCTGGGCTTCAC CAGGCCAAATCATCTGTGGTTGGAAGACCCAGGTCCAAAGAAAATAGGCCTCATACAAGC CTCAGTGACCACACCTCATCCCGAATGCTGTTGCTGCAGGATGGGGTTCCCTGACGAGGG CAGAAGAAGTATGAGCCTTCTGGGGTCCATGTGTCATGGTGTGGACTACCTTGGCCAGGT CTCTGACCCAGAGGTCAGCCCCACACCTGCAGCTAGAGATGGGGCCTTAGTTGGGGAAGC CCCTAGGCTCACCCTGCTGACTGCTGCCCTCTCCCTGCAGCTGGCCTTGACTTTGAAGCA ATCCTGCTGCAGCCTGGCAGCCCTCCAGATAAGACCCAAGTGCCCATGGTGGTCATGCCC CACGGTAGGCATCTGGCGTTAAGAGCCCTTGCCCTCCCAGCCCTCTTCCTAGCTGGCCCT TTCACCCTCCGCTCCCTGTCTGCAGGGGGGCCCCATTCATCCTTTGTCACTGCCTGGATG CTGTTCCCAGCCATGCTTTGCAAGATGGGCTTTGCGGTACTACTAGGTGAGTGAGCAGGG ACCCACAGTTCTGTTAGGACTACAGTGGAGTGACGGGGGTGGACCTGGTTTGTATAAGTA CCATGGGTGCCACTCTAGTCTCCAGGACTTTCTCTAGCCTAGACCTAGTAACCACTACCA GGAACTGCTGGGGCCCAGCCTCTGGTTCTGTGGCATAGTGATAACAAGGACTAACTCGGG ACTTCCAAGGAAAGGGCGCTGTGGTCACTGGGTGGCAGCCTCAAATCTCTGAGTCCCTTC CCCTTGACCCCTTGACAGTCTGTGGTATAGCTGGCCCCAGGGCCTACTTCACAGATGTGT GAAAAGAGCGTCGAGGGGGCTGGGAATGTTGCCTGACTACACTGTCTGGTCCCTCCCTGC CCTCAGTGAACTATCGTGGCTCCACGGGCTTTGGCCAGGACAGCATCCTCTCCCTCCCAG GCAATGTGGGCCACCAGGATGTGAAGGATGTCCAGGTAGCAGGGGCTGGGGCTTCTGGAC AGGCTGAAACATGGGCTGCCAGGGGGATGCCTCCATTCAGCTGAGCGGGCAGCTGGCTGC AGCATGCTTTGTCCCACCCTGCAGTTTGCAGTGGAACAGGTGCTCCAGGAGGAACACTTT GATGCAAGCCATGTGGCCCTTATGGGTGGTTCCCATGGTGGCTTCATTTCCTGCCACTTG ATTGGTCAGTACCCAGAGACCTACAGGGCCTGCGTGGCCCGGAACCCCGTGATCAACATC GCCTCCATGTTGGGCTCCACTGACATCCCTGACTGGTAGGCATACACCACAGGTCCCTGC CCTTCCCTCCTCTACCTCAAATTCTCATGGAGCCCCGTAGCCCCAGAATTCCTGGGGCTG CAACAGCTCGGTGTCTTGCAGGTGCGTGGTGGAGGCTGGCTTTCCTTTCAGCAGTGACTG CCTGCCAGACCTCAGCGTGTGGGCTGAGATGCTGGACAAATCGCCCATCAGATACATCCC TCAGGTATGCAGCCCCCTCCTTGCCCTGTGTGCTGCCCATCCATCCAGAATCCAGGGCCC AGCTCAACACAGCTCCCCACTCTTCCCCAAACACCCAGGTGAAGACACCACTGTTACTGA TGTTGGGCCAGGAGGACCGGCGTGTGCCCTTCAAGCAGGGCATGGAGTATTACCGTGCCC TCAAGACCCGGAATGTGCCTGTTCGGTGAGTGCAGCATGAAGGCCCTGGCAGCTGGTGGG CAGGTGAGCACAGGAGGACCCTCCAACCTTAAATGTTGCTGACTAATCCCTACAGGCTCC TGCTCTATCCCAAAAGCACCCACGCATTATCAGAGGTGGAGGTGGAGTCAGACAGCTTCA TGAATGCTGTGCTCTGGCTACGCACACACTTGGGCAGCTGAAGCCCTGCCATTCTGCATG AGCTGATCAGCCTGTGCCACACTTCGCTCTTGAGGAGCTCAACGGTCTGGCAGGGCAGCA GGAGGCTTTCTGGGCTCTGGACTCCACGGATGCGTGGGCAGAGGAATGTGGGCTATGTAG TCATAATAAATTAGGACACA OMIM ID 102645