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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for APEX1 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 328 Official gene symbol APEX1 Full name APEX nuclease (multifunctional DNA repair enzyme) 1 Aliases ,APE,APE1,APEN,APEX,APX,HAP1,REF1, Gene summary Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. [provided by RefSeq] Location Chromosome: 14   Locus: 14q11.2-q12 Gene position 20923290 - 20925926  Map Viewer Gene orientation plus Gene size 2637 bp Gene sequence >APEX1:1923290..1925926:Length=2637 CAGACAGACCAATCACGCGCATTCTTCGGCCACGACAAGCGCGCCTCTGATCACGTGACC AGGTCCGCTACCCACGTGGGGGCTCAGCGTGCACCCTTCTTTGTGCTCGGGTTAGGAGGA GCTAGGCTGCCATCGGGCCGGTGCAGATACGGGGTTGCTCTTTTGCTCATAAGAGGGGCT TCGCTGGCAGTCTGAACGGCAAGCTTGAGTCAGGACCCTTAATTAAGATCCTCAATTGGC TGGAGGGCAGATCTCGCGAGTAGGGTACAAGGCACTATGAAATGATCTAGTTTCGTGGGT GAGGGGCTGAAGGGCCTATGATGCACGGAGGCGGGGAAAGGATTTAGAGATAACGTGGTT TGAAAGGCGGGACCTGGTGCGGGGACGCTCTTGGGAGGAGTCTTCTCCCCAGCCTTAGCT GGTTTCATGATTTCTTTGCGTCTGTAGGCAACGCGGTAAAAATATTGCTTCGGTGGGTGA CGCGGTACAGCTGCCCAAGGGCGTTCGTAACGGGAATGCCGAAGCGTGGGAAAAAGGGAG CGGTGGCGGAAGACGGGGATGAGCTCAGGACAGGTAAGGGAATGAAATCAGCCCTTCTTC CTAGAAGCTGCGGCGGGGGTGTTTGTCATTCCCTTGATGTACGGTAAGTACGGGCCGACT CATTTTTGCAGGGGTTTGTGAAGAAGTCGCAGGAACCGTAGGCTTTCGTTGGGTCTATAG TTAACGCCGGATCGCAGTTGGAAACCACCAGCTTTTTGTCAGTATATATTACTCATTTTA TAGAGCCAGAGGCCAAGAAGAGTAAGACGGCCGCAAAGAAAAATGACAAAGAGGCAGCAG GAGAGGGCCCAGCCCTGTATGAGGACCCCCCAGATCAGAAAACCTCACCCAGTGGCAAAC CTGCCACACTCAAGATCTGCTCTTGGAATGTGGATGGGCTTCGAGCCTGGATTAAGAAGA AAGGATTAGATGTGAGTGGAATTTGAGGGAAAGAGACATTTTTTAGTATTGAATGGTCTT AGGGTTTAGTCACCCCTTTTCTCCGTTTAGCCTTCAGGCTGTTTTATTTTTCTCCTGCCC GTAGTTTTCTGTGGGGCTTCCCCAGTCTTGCCAGTTGTATTTCCTAAATGTCTGTTCCTT CACTTCCATTGCCATTTTCTTTTTTAGTGTTCTCTCCTCTTCCCAGAATGTTGCAAAAAC CTCTTCACTATACTTCCTCCATTTTATCTTCCTGCATTGCATTCCATATGAAGCATGTCC TCCATTCCATTAACCATAGCTTAAAAATCTTAGCTTGCTATCCACTGCCTATAGAAAAAA CACATCTCCTTGGCATAGCATGTAAGACTTTCTTACCTCTCTATATTTGTTTTCATTTAT CTAGCTTAGAATTGTTTGAATATTGTGCTGCTTGACTCGAACTCCTTAGGCCAAGAGACT GTTTAACCCGTGCGTATCTATGACTTAGCATATAGATTATTCAATAAATGTTCTGCTGAA TTGATAATACGTTTTCCACCTTTCTTTTCACTTACAGTGGGTAAAGGAAGAAGCCCCAGA TATACTGTGCCTTCAAGAGACCAAATGTTCAGAGAACAAACTACCAGCTGAACTTCAGGA GCTGCCTGGACTCTCTCATCAATACTGGTCAGCTCCTTCGGACAAGGAAGGGTACAGTGG CGTGGGCCTGCTTTCCCGCCAGTGCCCACTCAAAGTTTCTTACGGCATAGGTGAGACCCT ATTGATGCCTAATGCCTGAACTCTTCAAAACCAATTGCTAATTCTCTATCTCTGCCCCAC CTCTTGATTGCTTTCCCTTTTCTTATAGTTTTTTATGCTAATTCTGTTTCATTTCTATAG GCGATGAGGAGCATGATCAGGAAGGCCGGGTGATTGTGGCTGAATTTGACTCGTTTGTGC TGGTAACAGCATATGTACCTAATGCAGGCCGAGGTCTGGTACGACTGGAGTACCGGCAGC GCTGGGATGAAGCCTTTCGCAAGTTCCTGAAGGGCCTGGCTTCCCGAAAGCCCCTTGTGC TGTGTGGAGACCTCAATGTGGCACATGAAGAAATTGACCTTCGCAACCCCAAGGGGAACA AAAAGAATGCTGGCTTCACGCCACAAGAGCGCCAAGGCTTCGGGGAATTACTGCAGGCTG TGCCACTGGCTGACAGCTTTAGGCACCTCTACCCCAACACACCCTATGCCTACACCTTTT GGACTTATATGATGAATGCTCGATCCAAGAATGTTGGTTGGCGCCTTGATTACTTTTTGT TGTCCCACTCTCTGTTACCTGCATTGTGTGACAGCAAGATCCGTTCCAAGGCCCTCGGCA GTGATCACTGTCCTATCACCCTATACCTAGCACTGTGACACCACCCCTAAATCACTTTGA GCCTGGGAAATAAGCCCCCTCAACTACCATTCCTTCTTTAAACACTCTTCAGAGAAATCT GCATTCTATTTCTCATGTATAAAACTAGGAATCCTCCAACCAGGCTCCTGTGATAGAGTT CTTTTAAGCCCAAGATTTTTTATTTGAGGGTTTTTTGTTTTTTAAAAAAAAATTGAACAA AGACTACTAATGACTTTGTTTGAATTATCCACATGAAAATAAAGAGCCATAGTTTCA OMIM ID 107748