Entrez gene ID | | 3376 |
Official gene symbol | | IARS |
Full name | | isoleucyl-tRNA synthetase |
Aliases | | ,FLJ20736,IARS1,ILERS,ILRS,IRS,PRO0785, |
Gene summary | | Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Two alternatively spliced variants have been isolated that represent alternate 5' UTRs. [provided by RefSeq] |
Location | | Chromosome: 9 Locus: 9q21 |
Gene position | | 95056038 - 94972625 Map Viewer |
Gene orientation | | minus |
Gene size | | 83414 bp |
Gene sequence |
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OMIM ID | | 600709 |