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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for IDH1 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 3417 Official gene symbol IDH1 Full name isocitrate dehydrogenase 1 (NADP+), soluble Aliases ,IDCD,IDH,IDP,IDPC,PICD, Gene summary Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. [provided by RefSeq] Location Chromosome: 2   Locus: 2q33.3 Gene position 209119806 - 209100953  Map Viewer Gene orientation minus Gene size 18854 bp Gene sequence >IDH1:complement(59310371..59329224):Length=18854 CCTGTGGTCCCGGGTTTCTGCAGAGTCTACTTCAGAAGCGGAGGCACTGGGAGTCCGGTT TGGGATTGCCAGGCTGTGGTTGTGAGTCTGAGCTTGTGAGCGGCTGTGGCGCCCCAACTC TTCGCCAGCATATCATCCCGGCAGGTAACCTCAGGCTCCAAGGGGCGGCCCCGGTCCCTG GCTGTGGAGGGGTGGCTCTAATTCCGCAGAAGGCAGGAATGGGGTAAAGGAAAAAAGCGC AGATCTTGGGTGTGGAGGGAGTCAAGGCCTGCGTGCAAAGAAGGGAACAAATCCAGGTAT TGAGAATGGGAAAAGAAAAGGGAAGGAGGGGATGCTGGATGCTTGGATATGCAGAAGGTC TGCTTTTGGGCCTGGGAGGGAGAAACTGGGCGGTGAGGAAGTTGGATGCAACGACAAGGG GAAAATCAGGTCTGCACTTGGGTTGGAAAATCGAGGGGTGGAAGTTGCAAGAATGCATGT AGAAGACTAAGCCTGGAGTGTAGGAGGAAGAAAACGTGCAGCAGCTGGGGGCTGGATGCA AAGAAGGCTGTAAGCCGCAGACGGGCGTCTGCAGGCAACTCAGGCGGCGAGGAATAGCCT TGAAGCCGATCCCTCGCGTCCGCCAGGGGGCGTGGAGGGGCGGAGCTCCAGCGGCCTTCA GAGGGGTCGCTAGGCCACACGGGGCGAGAGGGGGCTGGGGGAAACACCCCCGCCAGTTCC GGGTGCCTGGAGTTTAAAAGGTCCCAGCACCAGCGAGGGGAGGGGAGGGGAGGGGCGGGC GTGGAGACCTGGAAGGAGGTACCGATCCAGCCTTGATTGCAGCCCTCTTGCACAACGGCC ATAAGGACGGGTGCAGGCCAAGAGCAAGGACATGCAAACCCCAAGACCTGCTAACGGGCG GCGAAGCGGGGGCACGCCCTCGCACACGCAGAGATAAATTGTGCTCCCATGACCTTTATT TGGAAAGTGCCTGCGGGCCTAAAATTGGCCTTTGTCCCACCGAGTACACTCAGCACTGTA CTTTAAACCGGATAAACTGGGCTGTCTGGCAGGTACTAAAAACAGCTAAATTCTCCTGTG AGTGTTCTGTATGTTAACACTTTTATTCCTTGTTTTGTTTTAGGCGATAAACTACATTCA GTTGAGTCTGCAAGACTGGGAGGAACTGGGGTGATAAGAAATCTATTCACTGTCAAGGTG AGAATTAGCAAATTTTCCCCCTTCTTCTGTACTTTCTTTGATGTGGCAGTACAGTGTTTA ACTGGTCTTGGGGGCAGGCCGAGGCACTGCAAGGGAATGAGTGAGGAATATTTCCAACAA CGAATTCCAACAGCTTCCTTGTTTCTTTTAATACAGTGTCTTATCTGCAAGAGATCCTTT TTGCCCAGAAATTATTGTAGTTCATGAACTCGGCAAAAAACAATCTGGCCAAAAACTTGA GGTTGATGAAAATAATATTAAATGGCTCTTTTTTTTCATTAAACTACTCTGTATTGTTAT TCCAGGTTTATTTTCTGGAATTGCACAATTATGTTAGGAGATAGGATTCAGCTACTTCAT ATGAGCTGGTGCCTGCTGGTCTTGGAACAGCCCTTCCTTCTGAAGTTGGGATTGGGTTGG AGACAAAATCTGAGGGGCAACAAAGGTGGAGAAGTCAGTCCAGTGGGGCCTCAAGCCCAT CCCATGGAAATCAGATCCAGAAGAAATACAATTATGTTCCACATGGTAGTAACAATAAAG CTTCACTGTTTTAGTTAAAAGATGGTAAAAATTTCATGGCTAAGTAATGTGAGGAAAACC TGAAGCGTCTGAAGTATGCATTATGAGATAAAGAAAGATTACTGCAGAGAGTACAGTTGC TTTAACTGAGAAGGAAATAGTGAACTAAAAAGATATCAGTCTTCACATTTTAGGTACAAT ATTTGACCTCTATTAACTGTATTTGCCATCAAGAATAAATTGCCATGTCATGACTGTTGC ATCATACTATATAGGGACATGGCCATGGAAGTGTATTATCAGGAACCAGATAAGTTCACT GCCTCCTTTTTTGCTTTGTTTTAAAACAAGGATAGGTGTGACAGTGGAATCAAACATGAA CTGAATCATATGCTTTCAGCTGTACTACAAATTATACTTGACATTACAAATGGGAAGTAA TTGACTCATCCACACCATTCTGTTCATTTCTTTTAGTCTAGTTCAGTTCCAGAAGGTTCC CCCAAAGGAATCTCCTAAACACTAGTAAGAAGAATTCTAGAATTGCGAATTTGGGAAGTG AAAATGGGCCTGGGGATTGGAAATACATCCAGGCTTGTCAAGAAACAGACGCTTACTGTC TACTAATCATTACATTTTTATTTAAAGACCAAATTACTTTAGCTCAATTTTTCAAGAAAG ACTATTTTAGGCTTCTTATCTAATAATTCTTTAAAGTCAATTCTCTTGACTTTTTTAGTC CTTAAGAGAATAAAAGCAATTTGCAGCTGTGTTGTTGGATTAAAAAAGAGTTTCGATTAG AGCATCATTAGAAGGAATAGATAACTTTTAGCAGGCTCAGAGCTTCTTCTGCCTCTAGGG ACAAGCTGGGACAGTTTCATTTCTTCCAAAGCGTCCAACCTTGCACTTTCTGAGAATCAG ATTGATTTGTATATGCTACCCCCACACCCTATCCTTAAAGTGCTGTCTTCCTAGGACAAT GCACAGTTTGTCCTATCCCACTCACTAGCAGCTTACCCTTGCCTGTGAACAGCCAGAAGA AGATGACAGGGACATGCTTGGGTCCTGGGCAGTGGCCCTACTGTATAGAGATTCTTCTAA TTGAGAAATCACTTTGTTGTATTTAGCCCCACATCTCCAATGTCTGTGTTATCTCTAGGA AAACAGTTCCACCAGGAATTCTTCGTCTCGCTTTTAGACTTAAAGTTTCCCTGAATATGG GTCACAGGAACCAGCTGAATCTCCTCATGGCTAGTTATTTTTATTAAATAACAAAAACAG CCTCTTAAAGGAGGAGAAATGCTAGCACTCACCATTCTGGACATCTTGAGAGCCCAGTAA AATGATGAGTTGGACTGAAGTGTTCAATAAACATGAGATTGTGGAAATAATCTCATTTCT TAAGACAAACCAGTAGTTGAGAATAATGATTGCATTATGAAGGGCACGTTATAGGGTCAG GCTCTGCCACGCTCTAGCTAGGTGGCCTTGGGAAAGCTCTTTTTTTTTTAACAAAGTAAA ATGGGGAAATGATGGCCATTTTTTTGGATTGTTATGAGGGCTAGCTCAGAAACCGCGTGT GAAACATAACACAATACTTTGTTCAGAGAAGATACTCAATTCTAATGGTAAATAGAATTG CTGTTACTAGCTTTTTATTCAACTACACATAAATTGAATTGCATGAATTGTTCTTTTAGT AGTCACTACGTTGTTTATATAAACACTACGTTGTTTATATATTTCACTTTATAATGAAAT AAATGACAAGGCATGTATTTTTTTTTTCTTTTTAGGTTTATTGAAGTCAAAATGTCCAAA AAAATCAGTGGCGGTTCTGTGGTAGAGATGCAAGGAGATGAAATGACACGAATCATTTGG GAATTGATTAAAGAGAAACTCATTTTTCCCTACGTGGAATTGGATCTACATAGGTAAATG AGTTACCCCTCCGTGTAGCAAACTCAGAAAGGATAATCTGGCTGGGCATGGTGGTGCACA CGTGAAGTCCCAGCTACTTAGGAGGCAGAGGCAGGAGGATCCCTCAAGACCAGGAATTCA AGTCCAGCCTGGGCAACAGAGTGAGACCCCATCACTTTAAAAAAAAAAGGAAAAAAAAGG GAAGGAGAAACAGGAAAAAAAAAAAGAATATAATCTGAATTATTTTGAGGTGAAGTTAGC TTTTTTTATATAGATATAGCTGTGTTTTGTGAATAAAGTTTGTTTTAAGCCTAAATATAT TCAGATGAATCTTCTAATTTTAACATACTGCTAGAAAAACTGGATTTATCATCTAAAAGT CAAGAATTATAAGGGAAAGAATGATTTTCAGATTCTTCTAACCTTCTGTTTCCTGTGAAG GTTTTATTTGTAATAAAACAGTGGCTAAGAATAGTACAATGTATTGAGAAAAGGGAAATA AGAGAGGATGTAAGAAACAGTAAACTAAATGCAGTTAACACAATTTTGTCATTTCAAACT CAATTTTCTATCACTTTACTTAGTCAATGGACCTGTTTCCTTTTCATGCCTCACCTTTTG CCCTTTTCATACAATTGTAGTGCAGAAAGAATTCATGATGTTTCTTAGTTGAACCCCTCC TTTCCAGCAAAATTCCCTTAAATCCTGTGTCCCTTTGCCCTGTGTGTAAAGTGCCTGGGG ACAGATGCAAAAGTCTATGTAATTCTCTCATTTTTTTCGCTGTGTTTTTCATAAACTTGC TTCTGTTCTTTGTACCTTTAGGTAGAGATAGAATTTTTAAAAGGGTAAAGTGGCTGAAGA CTGGCATAGAAAAATATTGAGCAACACGTTTCAGCCAAACTATTGGCAACTCTAAGTGTG TTTGCCTCAGCCCAGAATTAGTCATCAAAATTTGTCCTAAGGACCTGTTTGAGTGGAGAC ATTTAATTCACATAATGTCATTAAACATACTTTTTAATTGTTCTAAACCTAAGCTGCTGA TGTCTATATTGAAATCATGATAAGATATAAATACTTGCAGAAGTCAACCAAACATAAGAA ATTAGGCATAAAAACATCTTCCAACTAGGTTAAAAAAAAAAAGCATCTTAGGAACTCCTG TTTCAGGACTTTACATGACAGTAGGTGAACTGGCAGGGTTCTTTTCCTTATAATGGCTGC AACTAAAGATGCTTTGAGCCTCTTTAGTGTGGAATCATGAGGAGTTTTAAAGGGGAGTCA CTATGACTAGGAGGAAAAAATTTGGTGGCTGCAGACTAGATAATTTTTGGAGGCTCAAAC AAGTTTTAAATTTTTCCAAAATTCCTATTATTATCACTGACTGGTTCTTTTTCAGGAGAA TGGAGCAGGTAGTTTGTTTTATGTAGGCTGGACAGTGGTCTGGGCAATTTGTTCCTTCCT TTCTTATCTTCTTAGAAATGTTAAGAAGACAAGCAAAAAATCTAATAATTTGCTGATAGA TTCTCCTTATGAGAAATGGTTCCTAGGAACTTGAAAACTACTGATCATACTTCCTGTTGG AGTTGGGATTGGATCAACATTTCCTATGCAAGAAGATAACAAAGGACATGACTTTGTTAG ATTTATATGAATTATCTAAAGTCGAAGCAGTTGGAAGTTATTTTTATTTGGAAATATGTC AAGATTACTATCTCTTTGTTTGCATCATGAGTTGGGTAGGAGATCTAAGAAAGGAAGATA AGGGAACCAAAAAGAAATCTAGAGGCAGGTTTTAAGAGCTGAAAAACCTTTTAAATCCTT GGAGAACAGAATAAACAAAACATTATTTTGTTTTCTTGCTTTTTAACAAACTATTGCATG CTTCAAATAAAGCTTTGCAGTCATTTTCTATGCTCCCTGGACAACTAACATTCTTTCAGC TCTGAATGACCTGCAATCTTTGTGTTGGTGTATATTAAGCTATTACTCTCTGGTATGTAG AAAACCATTGATGGATTCCTTTACTTACCCAATAAATTGTAGGCTTGTTTCCAGAGCAAA CACTTGCTCAAGAATTACAGAAGGAATTAGCTGGGCATGGTGGTGCATGCCTGTAGTCCC CGCTACTGGGGAGGCTGAGGCGGGGGAATCACTTGAACCCAGGAAGGCAGAGGTTGAGTG AGCCAAGATCGTGCCACTGCACTCCAGCCTGGGCAACAAAACGAGACTCATCTAAAAAAA AAAAAAAAAGGGAAAGGCTCATTTTATGACTAACTGGCATTAATGAAGTAGTCATTCGCA TTTTTGGCATCAACTGTCACATCTTTACCTCCCACCACTTCAACGTCAAAATACAAAAAA TCCTTTAACCCCTCCCACCCCCTTTTATTTTTAAAGAGCAATATTTACTAAGGGAAAAAG GTGGTCCTTAGACTTACACTTATTATACTAATTATATGGAGAGAAACCAGGCCATTATTG CCTCTATCTGGTGAAAAACAGGAGGCAAAGGGCAGAGTTTGATGGTTTCCATTCATTTTC CTGATAGACAGCTTCCCATTACAAGAGGAGGGGCAGCCCAGCAGTCTAGCCTCTCTTAGT TCTCTTTGTAGTTGGCACCCATCTTCTGTGTTTAGGGTGTGCCAGTGCTAAAACTTGGCA GATTTTGGTGTACTCAGAGCCTTCGCTTTCTGCATAATGAGCTCTATATGCCATCACTGC AGTTGTAGGTTATAACTATCCATTTGTCTGAAAAACTTTGCTTCTAATTTTTCTCTTTCA AGCTATGATTTAGGCATAGAGAATCGTGATGCCACCAACGACCAAGTCACCAAGGATGCT GCAGAAGCTATAAAGAAGCATAATGTTGGCGTCAAATGTGCCACTATCACTCCTGATGAG AAGAGGGTTGAGGAGTTCAAGTTGAAACAAATGTGGAAATCACCAAATGGCACCATACGA AATATTCTGGGTGGCACGGTCTTCAGAGAAGCCATTATCTGCAAAAATATCCCCCGGCTT GTGAGTGGATGGGTAAAACCTATCATCATAGGTCGTCATGCTTATGGGGATCAAGTAAGT CATGTTGGCAATAATGTGATTTTGCATGTTTTTTTTTTCATGGCCCAGAAATTTCCAACT TGTATGTGTTTTATTCTTATCTTTTGGTATCTACACCCATTAAGCAAGGTATGAAATTGA GAAATGCATATATGTATAACTGTATATTTACACACATTTAGCTAAAGGCAAATACAAATA AACTTACAAATAGGCGTCCATCTCAACACATTTTTTTTCAAACATGCTGTTTTTTTTCCT TTATCCTTTTATTCAGTTATACCATATGATATTGCCATTTTTATGTTGGTAATTTCATAT GGTTCAACCAGATCTGTGGTTTTCAACACTGGCTGCACAATAGGATCCCCTTACAAGTTT TTTTGGTGGTTTTGTTTTGCTTTGCTTGATTTGTTTCTTTGTTTTAGTTTCAATGCTTGA GTACCACCCTACACAAATTAAAATCTGAATTCCATGGGGTTCAGGCATTTTAAAGCTCCC CAGGTGAATCTAATGTGCAAACTTGAGAACCACCAAAGATTGTATTAAACATGATCCCAT CATGCATAAAAGAAAAAACTGGCTGGGTACTATGGTTCACACCTGTAATCCTAGCACTTT GGAGGCCAATTTGGAAGCACTGCTTGAGGCCAGGAGTTTGAGACTAGCCTGGACAACATA GCAGAACCCTGTCTCTACAAAAATGAAAAGTATTTCAATAATTATGTCAATTGTTCATGG AAGAGCCAGTTTTGTTTATTCATATACAAAGTGAGTAGGCGAAGCTGAGTGGGGTGGCAT GTGCCTATAGTCCCAGCTACTTGGAAGGCTGAGGCCTGAGGATCCCTTAAGCCTAGGAGT TCAAGGTTACAGCTATGAGCTATGATCACACCACTGCCTACGCAACAGAGCAAGACCCTG TCTCGAAAAAGAAAAAGAAAAAAAAAACTGACTCGGTAGTTGAAAGCAGCCTTACTAAAG CATTCCTTCCTGCCTGGAAAAAAAGTATTGCTTCTTTACTTCTGTACCAGTACACTTGTT GCCAAATTAAGCAAAAAAACTGCCAAGTAAACAAAATCAAAGTTCAGTGTTGAAACTGAG GTTTCAGACTTTCACAGAAAGTAGTTTATGTCTTAAAAGGACCTTAAAAACAGGAATCTC TCATGCTGAAATCCAGAGGTTTTAATGTAGCCATCATTGAAAACAGTGTGTTGAGGGTAA ACAGTTTAGTCCTTGAGGGGTCAGTTAACTTTGTTCCACTCTGTGGCTAAAACTATCCTT TCATCCTGGCCAAAGCCTTCAGAAATAGCTCCCAGGGGCCCAAGCAAGGGAAGGTAGATG GCAGTGGTGCAAACTCGCTAATCTTGTAAAAATCACCCTAGATTCTTTCCAGTTCAGTCG TGCCTTTTTTCTGCGTATATCCTTTTTGTTTTTTGTTTTTGAGACAGAGTCTCGCTCTGT CGCCCAGGCTGGAGTGCAGTGGTGTGATCTTGGCTCACTGCAACCTCTGCCTCCCGGGTT CAAGCAATTCTCCTGCCTCAGCCTCTTGAGTAGCTGGGATTACAGGCACATGCTACCATG CCCGGCTAATTTTTGTGTTTTTAGTAGAGACGGGGTTTCACCATGTTGGTCAGGCTGGTC TCAAACTCCTGACCTTGTGATCCGCCCGCCTCCGCCTCCGCCTCCCAAAGTGCTGGGATT ACAGGCATGCCACCATGCCCGGCCTTCCTCTTTTTTTTTTTTTTTTTAATTATTTTGGCA TCAGTCATTTGTAAAAATGGCCATTCTATTTATTAAAGTCCAGAAAGAGAATTTCAAACC TCAGGTTGATTCATGGACTGTTTAAATATACATAAACCTATACAAAGCATTTATGGTGCT TTGGTACCTCAGTTTCTCCCTTTTCAGAAATAGTAATAAATTACCACCCATATTTACTTT ATGGATTTTATATGTCAAAAATGTTCTGTGTAAAGTAGGTGTTTAATCTTTATTGTTACT TACTGCTCTTTTACCAGTTGTTATTAGTATTTCTCTACACTTATAGATGTGGCCGGCACC TGCTGGTACCTAACTCTGCAAGTATCTGATTCAATTCATTGAAGAAGATACAATGCAGCA AAGACTTATGGATGTCTAGTATATGCCAGGCATATTATTCCACTGAGTAGCTGAGGCCCA TGAGGGAGGTGCCTGTCCTTGAACAGCCCTTTCCTAAAAATCATCATCATCCCATTGTAG CTGCTCCCAGAATGATTTGATTGCTCCATATGAACAAGTCCTATAACACTAGTAACAATG ATACCATGAGAGACCGAGCCCCGATGGCCTAAGTAAGGACGAGACCTCAAGTCCTTTGAC CCTGGATGCATTATTTCTACTATATCATAGTTCCCTCCTTGTAAGACTGATGTAAGAATC AAATGAGATTATGCAAGTTAAGCATTTAAAGCATCTGGCATAGAGTAAGGACAAAGCATT AGCTACCTCAGTACTACAATTAGTATTGTTATCATCACCCTCTAGGGAGACTTCCCTGAC TTCCTTCCATGGTCACCTCTTTTCCTCTGTCATCCTATAGTTTTTTTTTTTTTGGGGGGG GGGTCTAATACCCTCTTTTGGCATTTGAAAGCTCTTATATTGCTTTTCACTTATATATGT CTTTATAGGGTTGTAAACTTCCTAAAGGAAAGTGGCTTATGTTATTCTCTGTCCTCTTCA AATCAGTGCTCAGAAAACTTTCCTATACCTCGTATAGGCACCTAATAAATATTTACTGAT TTAGGGGAATGTCTGGACCTCTTCATCCCCATCTCCTAAAAAAAAAAAAAAAAAAAGAAG TTTGACATACTGCCCTATTTGTCTAGGTGTCTTCTAGGTCTATATTATATGAATATTCTC CTTACAATTCCTGCTAGGGTATTTTTTTTTTCTTTATACCTTTTTCCCCTCTACACAGTA CAGAGCAACTGATTTTGTTGTTCCTGGGCCTGGAAAAGTAGAGATAACCTACACACCAAG TGACGGAACCCAAAAGGTGACATACCTGGTACATAACTTTGAAGGTATGTATGACTGTAG CATAAGCTTCTTTTTTTTTTAAACAAATGATTTAGATAATATTTTTATTGCTTTTTTTGT TAGTTATGTGACTGCCTAAAAATATAATCTGAATCTACAGTGTTTTTGCAAAACCCGAAA CTTGACATAAAGAAGTAATTTGCTTCCATACCTTCCTGTGGCATGAATAAAGGCACAAAA GGGTTACCCACTTAATTGGAAATGCCTTTAGGCAAAGACAAGGAGATGATTATGCATTTA TCTTAAAGCACAGAGAGAAGGTTGGCAGAAATCTGCTGTGCATGAATTATATACATTAAA TATTAATATTCTCAAATCACCCAGCATATAATCCTGCCCTTTGCTCTGGTAGGGCTCTTG TATCTGGAAGAGGTTTCCTTATATATTTGCTGAAGTTTTCTTCTTGCCCTTCTGGGTATT TATCCTGTGAAAAAGTAGAACATTTGCTTTTTGCCTTTTCTTTCCCAGCTACCCTGCTAC CTTTGATGGCAAATCCCACCCAAAAGTTGTTGAAATAATTAGTGGGCCCTTTTCCTTCAC TATTGAAGTTGTTGAAAGCACTCACACAAACAAAAATACCCAACACTCACCTACCTTTTG TTTTTCTTGCCTCTTCCAAATAATATCTGTTGGAATCTGGTTCTGCAGGCTTCAGCACCT TTCACCCTGAACCCAAGTTAACCCTGAGCATTGGCATGGATTCAAGTTCTATCTTTAAGT AATAACAAAGTTCAATAATAGTTGTAAAACACAGTGATTACATGTAGCATAATTATTTCT ACTTATTTCTACCAACTACAGTAGGAGTGCTCAGTATCCTCCAGGAGATTATAAGAATTT TCATTCAGTATTTGAAATTTAAGTTTTTCTCAATAACTGAGGATTGAGTACACCCCTAAA GTTTAAAATAGATGTTGGGAATTGTAAAGGTAGGGTGTTTGTCCATTCTTGCGTTGCTAT AAAGAAATACCTGAGGCTGCGTAAGTTATAAAGAAAAGAGGTTTAATTGGCTCATGGTTC TGCAGGCTGTACAAGCCTGGCTCCAACACCTGTTCCTGGTGAGGGCCTCAGGAAGCTTCC AATCTTGGCAGAAGGCAAACAGACAATAGGTGTATCACATGGCAAGAGCGGGAACAAGAG AAAGAGAAGGGGGAGGTCCCAGACTCTTAAACAACCAGATTTCAAGTGAATTAACTGAGC GAGAACTCACGTAATCACCAAAGGGGATGGTCCTAAGCCATTCATAAGGGATCCAACCCC ATGTTCCAATCTCCTCCCACTGGGCCCCACCTCCAACACTGGGAATCACATTTCAACATG AGATTTGGAAGGGACAAATATCCAAACCATATCAGTATGTAAAAGAAGTTTCAAAATTAT TTGCCTTTTCTTAAATGTATTTCTGGTTCATATCAGTTTTTGGCATTTCTGCATCTTCAG GATTTTAAAGACTGTATGTTTTTTCATTTCTGCTGTCCTTCCAAAACAAGTTAGAATGTC CTTATCTAGAACTGGCTTTTCTCTCATTATGTGCCTCAGAAATTTGTTGGAAACCTGTCT GGGACTTCTGAAATCTAGTCTCAGATGTGAGAGCTGAGAAGTAGGTCATTTGGTTGTGGT GGGTGATTTTAGCCTTATTACAACTACATTACATTTATTCTTCTCCCTTTTTTCCTCTCA CTGGCTTCTCCTCTACAGAAGGTGGTGGTGTTGCCATGGGGATGTATAATCAAGATAAGT CAATTGAAGATTTTGCACACAGTTCCTTCCAAATGGCTCTGTCTAAGGGTTGGCCTTTGT ATCTGAGCACCAAAAACACTATTCTGAAGAAATATGATGGGCGTTTTAAAGACATCTTTC AGGAGATATATGACAAGTAACTATAGTTCTTTTTTAACTTTTTCTTTATTCTCAAGTAAG CTGACATTTGCATATAGAGTATGTATCTCCCTATCCCTATGATTCTGGGTAAATTGAGTG AAAATCATCACTGTCTCTTAAAGATAAGGGCAAAACTGAGGTTTAGCAGGAGTGAAACAA AACCACTCTGACTTGCTTTTATAAGATAAACATGTTCTTAAATAAGGTCCCCACATGAAT TGTTTTCAGAGCCAGGTTCTTTAATGTTTAAATAAACGTACGCTGTTAGTGATAAGTTCT AATTTTTCATGTGTGAGTTTCTAAGTCAGACCCATTTCCATTCTTTCTGAAGCCCATTGT TAGAATTTAAAATTCTGTTGGCCAGGCACGGTGGCTCATGCCTGTAATCCCAGCACTTTG GGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGT GAAACCCTGACTCTACTAAAAATACCAAAAATTAGCCGGGCGTGGTGGCGGGCGCCTCTA GTCCCAGTTACTGGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGGCGGAGGTTG CAGTGAGCCGAAATCACGCCACTGCACTGCAGCCTGGGCGACAGAGCGAGACTCCGTCTC AAAAAAAAAAAAAGAAAAGAAAAGAAAAAAAAGAATTTAAAATTCTGTTTTAGTGGAGTC ATTTGAACTTAAGTCTAAGTTTATAACAACACTGGCTTCCACAGCACAGGAGGTGAGCAT GTGTTAATATTTAAGATTGGCATAACTCCCTTTAGGTGCAAGTGTTCAGGCCAAAATGTT CCTGAGGCATTTTGATTCCTCCTCCTGCTGCCCATCTATACCAAGCCCAGAAACTGTCTG GAATATATTTTAGTTTCCTGAATGACACCAAGAAGTAGAACAGTCTTTTCAAAAATGTAT TTTAAAAATAAGCTGAATCTCAAGAATCTGATCTATAGTATAATGAAAACTGAAAAGTGA AGTAGTCATTGGGATACTCTACTGTCTCACTTAATTCTCACGGCTTCCCTGCAAGGTGGG TAAAATTGTTCCTACAGATAGTCAAATTGAGTTTTACAGTTAGAAAATGATTGGGCTAGG ATTTGAGCCAATGTCTGTCAGATTCCTGAGTTTCTGCTACTTCTACTAAAATATGCTGCT TCTTGTGTGTCCGGTCTTCTGTTTGGGACAAGCAGATGATATCCCTAACAAAATCAATTT TCTTTATTATTATTCTCTTTTACCTTTTGTTTCCCAGGCAGTACAAGTCCCAGTTTGAAG CTCAAAAGATCTGGTATGAGCATAGGCTCATCGACGACATGGTGGCCCAAGCTATGAAAT CAGAGGGAGGCTTCATCTGGGCCTGTAAAAACTATGATGGTGACGTGCAGTCGGACTCTG TGGCCCAAGGTACAGAGGTGGAGCCTGGCCTGTAGGAACAGGGTCATTCCAGGGTAGTTC TCTAATTTGGGAAGGGGAGTTTTGTAGTCCTTTGTTGTAAAATCTTGGAATGTTAAACCT CCAGGTCCACCGTCTTACCTGACAGCTAAGGAAATTAAGCTCAGACTAGAGAAATGATTT ACTCAAGACCACATGGGAAGTAAATTAGTGGATTGACACTCCTGGCTCCAGTGTCACTCC TTGAAGTTTTAAAGCCTACCTGATCTGAAAATCACTCCCTTTCCCTGCCCTCCTTGTCCT TTGGTGAAAATGTAAAAAACCAGGGCACTCAGGCAAGGAGGGATAAAGTGAGGAGCTTGA TCATGTCATAACCAAGCTTTGGTGCCTGCAAAGCTCATTTATTGGGCAGCAGGACCTACT CATGTCCCTCTGCCAGCTGCTGTTCTGGTAGAATATAAAACAAATGTGTTTGGCTGGGCA CAGTGGCTCACGCCTGTAATCCTAGCACTTTGAGAGGCCAAGGCAGTGGATCACTTGAGG CCAGGAGTTCAAGACCAGCCTGGCCAACATAGCAAAACCCCATCTCTACTTCAAAAAAAA AAAAAAAAAAAAATTAGCCAGGTGTGGTCGCATGCCTATAGTCCCTGGCACTCAGGAGGC TAAAGCATGAGAATTTCTTGAGCCTGGGAAGCGGAGGTTGCAGTGAGCTGAGATCACGCC ACTATACTCCAGCCTGGGCAACAGAGCAAGACTCTTGTCTCAACAACAACAAAGAAAAAG TGTTTTTGTTTACTGCTTAGCTTACACACAAATCAATTGAGCAAAGAACCCTAGGGGCTG TTTACAGAAATTCCAGGAGAAGTTTCATGCATGGGGTAAGGGCCAAATCAACAGAAACAC AGCGCCTGGTTTCCTCAGCACCAAGTTGCCCTTCAGTTTCAGTTGCCCTTGGTAGCTGTA TGAACTTGAATCTCCCCAGATGAATGTTTGTTAACTTTAATTATGTTTGTTTTTCCCAAG AAGTACTACTTTTTCTGTCTCTTATCAGTGTTAAACATCTCCTCTCAGTTTGAAAATCAG TAGATCAACCTGGTTAAAGATAACTTTTTGCCAGATAAATGAGTTACACAACTCTCCTTA CCATCCTTCTGTTTCTCTACATCCTCACAATCATTTGTACTGAATGCAACAGAGGAAGGA GTGTTATTGCTTTGTGATGACTCCGTGGTTGATTATTAACTTCACAGGTGATGTTGGGAG GTAGCAAAAATGGAGAAAAGAAGAAAATCAATTATATAGATATAAGAGTTGTAATGTGGT TCTTTCAATAAGAAACCACAGAAGAGAACTGTTGTACTGAGGGTATGAAAGAGAGCGAGG AAGGGCAACTGGGATGTTCTTAGATCCAACCGATCCTGTGTTTACCTGCCTTCTCTTCCC AGTCCCAGCAAGTGTATGAGCAGCTTGAGGGTTCTTAAGAGACAGCTCTCGTCCATCTTT ATTTCCCCAGAACAGCAGAGCATTGCACATAAGAATAACAATAATAGATTGAGCTCTGTG TCCAGTACTATTCTAAGGAATATAAATATATATTCATATATATTTATGAATATATGTATA TTTATCTAATCCCACAGCAACCTAGTGAAGTAGGTGCTGTTATTACTCCCATTTTACAGA TAAGAAAACTGAGCCGCAGTAGCTATGAAGTCATAGAACTAGAGTGGAATGTAGGCAGTT GGACCCTGAACCCTCCATCAAGGAGTAGGTATCCCTGAAATAAGTGAGGGGAAAATGCAG CCTTTCCAGACCCATTGGCTCTGATATCTGGAGCGGGGATCCTGCCTTCTGAAAGGCAGA ATTATTGGTGATTCCATGTGCTCTTGTTTACTTTGCTTACCAAGACCTATCAAGATTGAG TCATTTATGCTCTCATCTCTGAGAGACTCAGTGCTCTTCATGCAGTTGGACCCAACGCTT CATGCTCCACTACTTACAGGGTATGGCTCTCTCGGCATGATGACCAGCGTGCTGGTTTGT CCAGATGGCAAGACAGTAGAAGCAGAGGCTGCCCACGGGACTGTAACCCGTCACTACCGC ATGTACCAGAAAGGACAGGAGACGTCCACCAATCCCATTGGTAAGATGGTGTTTACATTG ATTTCTCACCAGAGAGTGCTCTCCAAAGCAGCCCAGATGTGTTCCCTTGGCTGCTCAGTG TTTTGTGTGCAAAGTCATCACCAAGTAGCTGATTTGTTCTACTAGTAAGATCTATTTGAA TATGCTTCTTAAAATATACAATATTTGCTTTTCTGTTTTGTGGGAGAACATAGGTTACAG AGAGGAATGTTATCAACAAGCATTTTCCTTTACCTCTGGTGCAGTGAAATGTCACATAAG GCTACAAATCTAAAAGTCACATGGATAGATCCTTTTAACAAGTTTCAAAGATAGCACTTC AAAAAGAGATTACAGCCTGGAAAAAGGAGACCAATATAGACAAGAGATAGAAGAGATTGT GACCTTTTTCAAATTAGAAAATGCCTTAAGTTTCAAACACTAGTACCATGCCATGAAAAT GTGTTTTTTTAAAGTTTCTGTTTGGTAAAATATTTCTAACTCTCCTAAAACTTCTAGCCC ATGTGGTTAGTATCTAAAGAAGTCTGTCACCTAAACAAAAAACTATTCTGTTTTGGGGAA CTATGAGACATTTGGAAACCTCTATAACTAGGATGATTGGAGTGTTGTGTTTTTTTTCCC CTCTTTTAGCTTCCATTTTTGCCTGGACCAGAGGGTTAGCCCACAGAGCAAAGCTTGATA ACAATAAAGAGCTTGCCTTCTTTGCAAATGCTTTGGAAGAAGTCTCTATTGAGACAATTG AGGCTGGCTTCATGACCAAGGACTTGGCTGCTTGCATTAAAGGTTTACCCAAGTAAGTAT AAGATGCCCTAGTTTCTATGGTCAAATTAACACTTATCCTCACTGGGCTCAGAGCATCGG TGCTTTCTGGAATTATATAAATTGTTATTCATCATCTAGTTCAGGAGTCAGCAGATATCT GTAAATTGTCAGATAGTGAACATTTTAGGCTTTGTGGAACATATAGTCTTTTTGCAACTA CACAACTATTCAACTTTGCCTCTGCCATTGTAGCAGGAAAGCAGTCATAGACAATACAGA ATCAAATGGTGTGGCTGGTACCAATCAAACTTTTATGTTCAAAACCAGCCTCGATTTGGT TCATGTGCTGGGCTGTAATTTGCTGACATCCCATCTAGTTGATAATCATTGAACGAAAAG GTTCTATTTAATTTTAAGAAGCAGATTATAGACAAATAGAAACAAAGATACTTCAGAGGC TATTTTATTCTACTCCTTTATTTTCTTTAACTTACTGATGAGAAAAGTGAGCAGCACAAG TTTAAGGTGTGCAATTGATTACAGTCCCTTAAGTATCTGTAACCAATATTTGGGCAAATA TTTGACAGCCCATATGTTTACTGAGAATTTTTCTGAGAACATAGTAGCCAGTATCCTGGG GGGATTGTCTCCATATCTCAACCAGTGCATCTGCAGAGGTCCCAGGTAGGGTCAGTATAC CCCATAATGGGGATATACTTGGTCACTGCATGTTTCTTAATTTAAATTTCCAACAAGATT GCAGTGTTCGCTGGGTGCTGTGGCTCATGCCTGTAATCCTAGCACTTTGGGAGGCCGAGG TGGGTGGATCACGAGGTCAGGAGATCAAGACCATCCTGGCTAACACAGTGAAACCCCATC TCCACTAAAAATACAAAAAATTAACCAGGCGTGGTGGCGGGCACCTGTAGTCCCAGCTAC TCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCTGGGAGGCGGAGCTTGCAGTGAGCCGA GATGGTGCCACTGCACTCCAGCCTGCGTGACAGAGCGAGACTCCATCTCAAAAAAAAAAA AAAGATTGCAGTGTTCAAAATGGTCTTATCAGTGGAATACCTTTGTAGCCTATTTAACAG GCACCTGTCAGCAGGATTATGTTATCCTGTCTTTTGTTTTTCTTTTTTTTTCTTTTTATT GAGACAGAGTCTCGCTTTGCCCAGGCTGGAGTGCAGTGGCGTGATCTTCGCTCACTGCAA CCTCCGCCTCCTGGGTTCAAGTGATTCTTCTGCCTCAGCCTCCCAAGTAGCTGGGACTTG TGCCACAACACCCGGCTAATTTTTTTTTTTTTTTTTTTGTATTTTTAGTAGAGACGGGGT TTCACTTTGTTAGCCAGGATGGTCTCCATCTCCTGACCTCATGATCCACCCGCCTTGGCC CCCCAAAGTGCTGGGATTATAGGCGTGAGCCACCAGGCCCGGCCTGTCTTTTGTTTTTCT TAAGACACTGATAGAAATAACAACATTATAACTTTTTTTAAGGACATGTAACGGTTTGTG GGAAGGTGGGTAAAGGTTTGGCTATGCCCTGAATAAGTTTTGTTATGTTTAAGAATGAGG AAGAAGTGTGATGATTTTGGTCTCAGCAGCATTAGTCTGAACCGAAACTCAATGATAATT TCACCCCCAAAGCTACATAGCAAGAAACCTAACTGAGTATGTATGGCTGTCTCTACTGCC GGTTGCCTAGAGAGCCTGAGTACTGAGCCTGGGTCAGCCCCAGGAACCCTGAACATAGTC ATTGTCTATAGATTTTGTAGCTTACTAACATGAATGCGTTTTCTTCCAGAAACAAATAGA ATACTATTTTAAGTAGCATTTCTAGGACTTTACCACTACCTGCTACCATATCAGAGACCA ACTAAATTTTCTTTTTTTTTTCCTTCCCGTTAGTGTGCAACGTTCTGACTACTTGAATAC ATTTGAGTTCATGGATAAACTTGGAGAAAACTTGAAGATCAAACTAGCTCAGGCCAAACT TTAAGTTCATACCTGAGCTAAGAAGGATAATTGTCTTTTGGTAACTAGGTCTACAGGTTT ACATTTTTCTGTGTTACACTCAAGGATAAAGGCAAAATCAATTTTGTAATTTGTTTAGAA GCCAGAGTTTATCTTTTCTATAAGTTTACAGCCTTTTTCTTATATATACAGTTATTGCCA CCTTTGTGAACATGGCAAGGGACTTTTTTACAATTTTTATTTTATTTTCTAGTACCAGCC TAGGAATTCGGTTAGTACTCATTTGTATTCACTGTCACTTTTTCTCATGTTCTAATTATA AATGACCAAAATCAAGATTGCTCAAAAGGGTAAATGATAGCCACAGTATTGCTCCCTAAA ATATGCATAAAGTAGAAATTCACTGCCTTCCCCTCCTGTCCATGACCTTGGGCACAGGGA AGTTCTGGTGTCATAGATATCCCGTTTTGTGAGGTAGAGCTGTGCATTAAACTTGCACAT GACTGGAACGAAGTAGGAGTGCAACTCAAATGTGTTGAAGATACTGCAGTCATTTTTGTA AAGACCTTGCTGAATGTTTCCAATAGACTAAATACTGTTTAGGCCGCAGGAGAGTTTGGA ATCCGGAATAAATACTACCTGGAGGTTTGTCCTCTCCATTTTTCTCTTTCTCCTCCTGGC CTGGCCTGAATATTATACTACTCTAAATAGCATATTTCATCCAAGTGCAATAATGTAAGC TGAATCTTTTTTGGACTTCTGCTGGCCTGTTTTATTTCTTTTATATAAATGTGATTTCTC AGAAATTGATATTAAACACTATCTTATCTTCTCCTGAACTGTTGATTTTAATTAAAATTA AGTGCTAATTACCA OMIM ID 147700