Entrez gene ID | | 3482 |
Official gene symbol | | IGF2R |
Full name | | insulin-like growth factor 2 receptor |
Aliases | | ,CD222,CIMPR,M6P-R,MPR1,MPRI, |
Gene summary | | The protein encoded by this gene is a receptor for both, insulin-like growth factor 2 (IGF2) and mannose 6-phosphate (M6P). The IGF2 and M6P binding sites are located on different segments of the receptor. This receptor functions in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of IGF2. While the mouse Igf2r gene shows exclusive expression from the maternal allele, imprinting of the human IGF2R gene appears to be polymorphic, with only a minority of individuals showing expression from the maternal allele. [provided by RefSeq] |
Location | | Chromosome: 6 Locus: 6q26 |
Gene position | | 160390131 - 160527583 Map Viewer |
Gene orientation | | plus |
Gene size | | 137453 bp |
Gene sequence |
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OMIM ID | | 147280 |
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