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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for IL12RB2 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID3595
Official gene symbolIL12RB2
Full nameinterleukin 12 receptor, beta 2
Aliases,-,
Gene summaryThe protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. [provided by RefSeq]
LocationChromosome: 1   Locus: 1p31.3-p31.2
Gene position67773047 - 67862583  Map Viewer
Gene orientationplus
Gene size89537 bp
Gene sequence
OMIM ID601642