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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for IL13 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 3596 Official gene symbol IL13 Full name interleukin 13 Aliases ,ALRH,BHR1,IL-13,MGC116786,MGC116788,MGC116789,P600, Gene summary This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq] Location Chromosome: 5   Locus: 5q31 Gene position 131993865 - 131996801  Map Viewer Gene orientation plus Gene size 2937 bp Gene sequence >IL13:40307737..40310673:Length=2937 AAGCCACCCAGCCTATGCATCCGCTCCTCAATCCTCTCCTGTTGGCACTGGGCCTCATGG CGCTTTTGTTGACCACGGTCATTGCTCTCACTTGCCTTGGCGGCTTTGCCTCCCCAGGCC CTGTGCCTCCCTCTACAGCCCTCAGGGAGCTCATTGAGGAGCTGGTCAACATCACCCAGA ACCAGAAGGTGAGTGTCGGCTAGCCAGGGTCCTAGCTATGAGGGCTCCAGGGTGGGTGAT TCCCAAGATGAGGTCATGAGCAGGCTGGGCCTGGTCCTAAGATGCCTGTAGGTCAGGAAA AATCTCCATGGACCAAGGCCCGGCCCAGCCATGAGGGAGAGAGGAGCTGGGCTGGGGGGC TCAGCACTGTGGATGGACCTATGGAGGTGTCTGGCAGACTCCCCAGGGACTACCTGCTCT CCTGGCCTGGCCTTGTCTGCCACTGCCAGCTCCTACTCAGCCATTCCTGAACAGAGGACA GCAGAGAAGGGCCAGCACCCTCCCAGAACCATGTGGCATTTGCCAACTGGATTTTGACCA TAACAATGCAGCCATTCTCCCCAGCACCATCATAGGCCCGCCCTTACAGGAGGATTCCTT AGTAGAGTCCGCTCCTTGCCCCACTAGTAACAGCTCACATGTCTGAGCACTGCTTACACC AGGCCTGGTGCACGTGCTTTATGTGTCATTTCATCACTGCCAGCCACCTCAAGAGGCAGG TACGATGAACCCATTCTGCTAAGGTTCAGTGAGGTTAAGTGACAGAGGCTGGATTCAAGC CAGGCCTGGCCAACACCAGAGTGTCCATGCTCCTAACTGCAGTGTTCCCTCACCATCAGA AGGCAGGGCATTTAATACACCAGATCCCCACCGCCTCCCATCTGATTTGTCTTGGTCAAC AGTGGCCCAGGCCACTCCTACTTCACTCGTCCCCACCCTGGCCCTTCCCGCAGGCCCCTG TCCTCCTGCCCTGACTATGGCAAGCCTTGCATGCAGCTTGTCCCTTACTAGTGGTGTCAA TTTTTTTCTCTCAGCTCCAAGACCCTAAACAGTGGGACCTCACCCCTATGCCTGCTGTTC AAAGCAGAAAACGAAGCTCAGGAATGCTGAGGGGCTGCCAGGCCTGCCTCTGTGCCACAC CAGGGATGCTTGTGGGGCCTGTGCTGGGGCAGACCTGGCCTGGGCTGCCAGGGCAGGCCC ACAACCCCTGCCAGCACTCTGCTCACTGTCACTTTGCTCCCACAGGCTCCGCTCTGCAAT GGCAGCATGGTATGGAGCATCAACCTGACAGCTGGCATGGTAAGGACCTTTGGGTGCAGG GAGGATGGGGCAGAGGCTCCAGGCCTTGGGCTTATCTTCTCTGAGCCTCCCTTCCATGGC TGGGGTTCCAAGCAAGCTTCAAGTGCTCTCCTCCCTCCCGCCATAATCTGGCCCCTTCCC GCCCACCACCCAGACTCACCTGCGCCAGGCATCTCAGCCCCATCTTCCTGCAGACTCACA AAAGGCAGCTGCCCAAGCAGGGCCTGACCCCTCGGTGTCCCCTCCCCACAGTACTGTGCA GCCCTGGAATCCCTGATCAACGTGTCAGGCTGCAGTGCCATCGAGAAGACCCAGAGGATG CTGAGCGGATTCTGCCCGCACAAGGTCTCAGCTGGGGTAAGGCATCCCCCACCCTCTCAC ACCCACCCTGCACCCCCTCCTGCCAACCCTGGGCTCGCTGAAGGGAAGCTGGCTGAATAT CCATGGTGTGTGTCCACCCAGGGGTGGGGCCATTGTGGCAGCAGGGACGTGGCCTTCGGG ATTTACAGGATCTGGGCTCAAGGGCTCCTAACTCCTACCTGGGCCTCAATTTCCACATCT GTACAGTAGAGGTACTAACAGTACCCACCTCATGGGGACTTCCGTGAGGACTGAATGAGA CAGTCCCTGGAAAGCCCCTGGTTTGTGCGAGTCGTCCCGGCCTCTGGCGTTCTACTCATG TGCTGACCTCTTTGTCCTGCAGCAGTTTTCCAGCTTGCATGTCCGAGACACCAAAATCGA GGTGGCCCAGTTTGTAAAGGACCTGCTCTTACATTTAAAGAAACTTTTTCGCGAGGGACA GTTCAACTGAAACTTCGAAAGCATCATTATTTGCAGAGACAGGACCTGACTATTGAAGTT GCAGATTCATTTTTCTTTCTGATGTCAAAAATGTCTTGGGTAGGCGGGAAGGAGGGTTAG GGAGGGGTAAAATTCCTTAGCTTAGACCTCAGCCTGTGCTGCCCGTCTTCAGCCTAGCCG ACCTCAGCCTTCCCCTTGCCCAGGGCTCAGCCTGGTGGGCCTCCTCTGTCCAGGGCCCTG AGCTCGGTGGACCCAGGGATGACATGTCCCTACACCCCTCCCCTGCCCTAGAGCACACTG TAGCATTACAGTGGGTGCCCCCCTTGCCAGACATGTGGTGGGACAGGGACCCACTTCACA CACAGGCAACTGAGGCAGACAGCAGCTCAGGCACACTTCTTCTTGGTCTTATTTATTATT GTGTGTTATTTAAATGAGTGTGTTTGTCACCGTTGGGGATTGGGGAAGACTGTGGCTGCT AGCACTTGGAGCCAAGGGTTCAGAGACTCAGGGCCCCAGCACTAAAGCAGTGGACACCAG GAGTCCCTGGTAATAAGTACTGTGTACAGAATTCTGCTACCTCACTGGGGTCCTGGGGCC TCGGAGCCTCATCCGAGGCAGGGTCAGGAGAGGGGCAGAACAGCCGCTCCTGTCTGCCAG CCAGCAGCCAGCTCTCAGCCAACGAGTAATTTATTGTTTTTCCTTGTATTTAAATATTAA ATATGTTAGCAAAGAGTTAATATATAGAAGGGTACCTTGAACACTGGGGGAGGGGACATT GAACAAGTTGTTTCATTGACTATCAAACTGAAGCCAGAAATAAAGTTGGTGACAGAT OMIM ID 147683