Database of mammalian genes
Home

Home Search Browse Statistics User guide FAQs Links Questions Contribute Download


Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for ILF3 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID3609
Official gene symbolILF3
Full nameinterleukin enhancer binding factor 3, 90kDa
Aliases,CBTF,DRBF,DRBP76,MMP4,MPHOSPH4,MPP4,NF-AT-90,NF110,NF90,NFAR,NFAR-1,NFAR2,TCP110,TCP80,
Gene summaryThis gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein was first discovered to be a subunit of the nuclear factor of activated T-cells (NFAT); a transcription factor required for T-cell expression of interleukin 2. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the larger of which is the product of this gene. These proteins have been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth; possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
LocationChromosome: 19   Locus: 19p13.2
Gene position10764937 - 10803095  Map Viewer
Gene orientationplus
Gene size38159 bp
Gene sequence
OMIM ID603182